For nearly 20 years, antidepressants have carried suicide risk warnings for young people. Now, experts are questioning if the FDA should reconsider these warning labels. Medscape Medical News
Tag: Neuropharmacology and Drugs
Ketamine induces plasticity in a norepinephrine-astroglial circuit to promote behavioral perseverance
Duque et al. show that astroglial calcium is recruited at active-to-passive transitions during learned-helplessness-like assays in both zebrafish and mice and that a variety of antidepressant compounds have consistent effects across both species. Ketamine, applied transiently, causes acute norepinephrine-mediated astrocytic hyperactivation followed by prolonged suppression to promote lasting behavioral resilience.
Revisiting reinforcement learning
Dopamine is a powerful signal in the brain, influencing our moods, motivations, movements, and more. The neurotransmitter is crucial for reward-based learning, a function that may be disrupted in a number of psychiatric conditions, from mood disorders to addiction. Now, researchers led by MIT Institute Professor Ann Graybiel have found surprising patterns of dopamine signaling… Continue reading Revisiting reinforcement learning
Probing Non Peptide Agonists Binding at Human Nociceptin/Orphanin FQ Receptor: A Molecular Modelling Study
The N/OFQ – NOP receptor is a fascinating peptidergic system holding the potential to be exploited for the development of, among others, analgesic drugs devoid of side effects associated with classical opioid signalling modulation. To date, up to four among X-ray and Cryo-EM structures of the NOP receptor in complex with the endogenous peptide agonist… Continue reading Probing Non Peptide Agonists Binding at Human Nociceptin/Orphanin FQ Receptor: A Molecular Modelling Study
Pain relief research: Naturally occurring hederagenin found to bind to the pain regulation receptor
[ASAP] Guanidine Derivative ADS1017, a Potent Histamine H3 Receptor Antagonist with Promising Analgesic Activity and Satisfactory Safety Profile
Personal interests can influence how children’s brains respond to language
A new study from the McGovern Institute shows how interests can modulate language processing in children’s brains and paves the way for personalized brain research. The paper, which appears in Imaging Neuroscience, was conducted in the lab of McGovern Institute Investigator John Gabrieli, and led by senior author Anila D’Mello, a former McGovern postdoctoral fellow… Continue reading Personal interests can influence how children’s brains respond to language
[ASAP] Psychedelics and Entactogens: Call for Papers
[ASAP] Psychedelics and Entactogens: Call for Papers
The Strange Untold Story of How Science Solved Narcolepsy
A three-decade series of coincidences will likely help doctors treat narcolepsy — and possibly prevent opioid addiction — and could lead to a Nobel Prize for two scientists who never collaborated. Medscape Medical News