AI SummaryThis article discusses new findings that show a single high dose of psilocybin can lead to significant changes in the brain’s functional networks. These results offer new insights into the therapeutic potential of psychedelics, suggesting they may have promising applications in various medical treatments.A single high dose of psilocybin results in dramatic changes to… Continue reading New Insight Into Psilocybin’s Therapeutic Potential
Tag: Neuropharmacology and Drugs
Distinctive Neurophysiological Signatures of Analgesia after Inflammatory Pain in the ACC of Freely Moving Mice
AI SummaryThe article discusses the use of head-mounted miniaturized microscopes to record calcium transients in the anterior cingulate cortex (ACC) of freely moving mice expressing a genetically encoded calcium indicator. The study found no intrinsic behavioral differences in the model and observed that ACC population activity scaled with stimulus intensity while single-cell representations were flexible.… Continue reading Distinctive Neurophysiological Signatures of Analgesia after Inflammatory Pain in the ACC of Freely Moving Mice
Designing safer opioids
AI SummaryResearchers have identified a strategy to design safer opioids by targeting an unconventional spot in the receptor to suppress pain with fewer side effects, particularly those linked to fatal overdoses.Opioid medications offer people relief from debilitating pain, but these drugs come with dangers: the risk for addiction, miserable withdrawal symptoms and the potential for… Continue reading Designing safer opioids
Research team develops method to design safer opioids
AI SummaryResearchers have developed an experimental compound that binds to an unconventional spot within opioid receptors in the brain, potentially leading to the design of safer opioids with fewer side effects such as addiction, withdrawal symptoms, and fatal overdoses. The study shows that this compound suppresses pain in animal models more effectively. An experimental compound… Continue reading Research team develops method to design safer opioids
Allen Institute launches neuroscience initiatives on perception, recognition, and psychedelics
AI SummaryThe Allen Institute has launched neuroscience initiatives through its OpenScope program to study perception, recognition, and the effects of psychedelics on brain activity. One project will focus on how psilocybin, the compound in magic mushrooms, alters cognition and perception at a cellular level. Researchers will use advanced recording techniques in mice to observe changes… Continue reading Allen Institute launches neuroscience initiatives on perception, recognition, and psychedelics
Study reveals how an anesthesia drug induces unconsciousness
AI SummaryResearchers at MIT have discovered that the anesthesia drug propofol induces unconsciousness by disrupting the brain’s balance between stability and excitability, ultimately leading to instability in brain activity. This new finding could help in developing tools for better monitoring patients under general anesthesia. The study also suggests that other anesthetic drugs might lead to… Continue reading Study reveals how an anesthesia drug induces unconsciousness
Propofol anesthesia destabilizes neural dynamics across cortex
AI SummaryThe article discusses a method developed by Eisen and Kozachkov et al. to measure changes in neural stability. They discovered that propofol anesthesia destabilizes neural activity, making it more susceptible to perturbation, leading to unconsciousness. This effect is attributed to excess inhibition in the brain.Eisen and Kozachkov et al. develop a method to measure changes… Continue reading Propofol anesthesia destabilizes neural dynamics across cortex
Cellular and circuit architecture of the lateral septum for reward processing
AI SummaryThis article discusses research that delves into the cellular and circuit architecture of the lateral septum in relation to reward processing. The study identifies Esr1-expressing neurons in the lateral septum as crucial for reward seeking and methamphetamine addiction. The findings present new opportunities for investigating the role of the septal region in regulating rewards… Continue reading Cellular and circuit architecture of the lateral septum for reward processing
Systems Genetics Analyses Reveals Key Genes Related to Behavioral Traits in the Striatum of CFW Mice
AI SummaryIn this study, researchers used systems genetics analyses to identify key genes related to behavioral traits in the striatum of CFW mice. They found that the brown and magenta modules were significantly enriched for striatal-related functional genes and were causally linked to dyskinesia. Hub genes Adcy5 and Kcnma1 were identified as important for motor… Continue reading Systems Genetics Analyses Reveals Key Genes Related to Behavioral Traits in the Striatum of CFW Mice
Chilling discovery: Study reveals evolution of human cold and menthol sensing protein
AI Summarystudy, researchers hope to develop more targeted pain medications that do not cause unwanted side effects. The evolution of the human cold and menthol sensing protein TRPM8 is being examined to potentially lead to the creation of non-addictive pain management solutions. The research aims to decouple the chemical sensing of cold from actual cold… Continue reading Chilling discovery: Study reveals evolution of human cold and menthol sensing protein