Abstract Background Clinicians treating cancer-related pain with opioids regularly encounter nonmedical stimulant use (i.e., methamphetamine, cocaine), yet there is little evidence-based management guidance. The aim of the study is to identify expert consensus on opioid management strategies for an individual with advanced cancer and cancer-related pain with nonmedical stimulant use according to prognosis. Methods The… Continue reading Expert consensus‐based guidance on approaches to opioid management in individuals with advanced cancer‐related pain and nonmedical stimulant use
Tag: Neuropharmacology and Drugs
Dynamical modeling of proliferative-invasive plasticity and IFN{gamma} signaling in melanoma reveals mechanisms of PD-L1 expression heterogeneity
Background Phenotypic heterogeneity of melanoma cells contributes to drug tolerance, increased metastasis, and immune evasion in patients with progressive disease. Diverse mechanisms have been individually reported to shape extensive intra-tumor and inter-tumor phenotypic heterogeneity, such as IFN signaling and proliferative to invasive transition, but how their crosstalk impacts tumor progression remains largely elusive. Methods Here,… Continue reading Dynamical modeling of proliferative-invasive plasticity and IFN{gamma} signaling in melanoma reveals mechanisms of PD-L1 expression heterogeneity
Nature: An unexpected source of innovative tools to study the brain
This story originally appeared in the Fall 2023 issue of BrainScan. ___ Genetic engineer Joseph Kreitz looks to the microscopic world for inspiration in Feng Zhang’s lab at the McGovern Institute. Photo: Steph Steve In their quest to deepen their understanding of the brain, McGovern scientists take inspiration wherever it comes — and sometimes it comes… Continue reading Nature: An unexpected source of innovative tools to study the brain
Summer research offers a springboard to advanced studies
Doctoral studies at MIT aren’t a calling for everyone, but they can be for anyone who has had opportunities to discover that science and technology research is their passion and to build the experience and skills to succeed. For Taylor Baum, Josefina Correa Menéndez, and Karla Alejandra Montejo, three graduate students in just one lab… Continue reading Summer research offers a springboard to advanced studies
Mapping the neuroethological signatures of pain, analgesia, and recovery in mice
AI SummaryBohic et al. utilize advanced techniques to discover hidden markers of pain using computer vision and machine learning. They identify the emotional and motor responses related to pain relief and injury recovery in animals, offering a novel method for developing painkillers in laboratory rodents.Bohic, Pattison, and colleagues use cutting-edge quantitative approaches to uncover hidden… Continue reading Mapping the neuroethological signatures of pain, analgesia, and recovery in mice
Studying consciousness without affecting it
Studies of consciousness often run into a common conundrum of science — it’s hard to measure a system without the measurement affecting the system. Researchers assessing consciousness, for instance as volunteers receive anesthesia, typically use spoken commands to see if subjects can still respond, but that sound might keep them awake longer or wake them… Continue reading Studying consciousness without affecting it
Silent synapses are abundant in the adult brain
AI SummaryMIT neuroscientists have discovered that the adult brain contains silent synapses, immature connections between neurons that remain inactive until they are recruited to help form new memories. About 30% of synapses in the adult mouse brain are silent, and the researchers believe this helps the brain continuously form new memories without modifying existing synapses.… Continue reading Silent synapses are abundant in the adult brain