Very early exposure to even a very small dose of herpes simplex virus (HSV) in infant mice can lead to cognitive decline later in life, according to new findings. This is significant because of emerging data in human studies showing an association between HSV and Alzheimer’s disease in humans.
Tag: Neural Diseases and Disorders
Stressed microglia turn to the dark side in Alzheimer’s disease
A microglia subpopulation termed “dark microglia” has been associated with aging and neurodegeneration, although its role has remained elusive. New research from Flury et al. in this issue of Neuron shows that dark microglia drive neurodegeneration via secretion of toxic lipids.
Multiple sclerosis: Cell-catching implant helps identify successful treatment in mice
A sponge-like implant in mice helped guide a treatment that slowed or stopped a degenerative condition similar to multiple sclerosis in humans. It also gave researchers a look at how primary progressive multiple sclerosis, the fastest-progressing version of the disease, attacks the central nervous system early on.
Seeing more in expansion microscopy
In biology, seeing can lead to understanding, and researchers in Edward Boyden’s lab at MIT’s McGovern Institute are committed to bringing life into sharper focus. With a pair of new methods, they are expanding the capabilities of expansion microscopy—a high-resolution imaging technique the group introduced in 2015—so researchers everywhere can see more when they look… Continue reading Seeing more in expansion microscopy
[ASAP] Dual GLP-1 and GIP Agonist Tirzepatide Exerted Neuroprotective Action in a Parkinson’s Disease Rat Model
Innovative blood test shows potential to replace spinal tap for Alzheimer’s diagnosis
Up to half of all people living with Alzheimer’s Disease in Ireland remain undiagnosed. Now, a new blood test may have the potential to transform patient care, allowing for better diagnosis, earlier interventions and more targeted treatments. Researchers at Trinity College Dublin, the Tallaght Institute of Memory and Cognition and St James’s Hospital, Dublin are exploring… Continue reading Innovative blood test shows potential to replace spinal tap for Alzheimer’s diagnosis
[ASAP] Corilagin Attenuates Neuronal Apoptosis and Ferroptosis of Parkinson’s Disease through Regulating the TLR4/Src/NOX2 Signaling Pathway
[Articles] Safety and efficacy of nerinetide in patients with acute ischaemic stroke enrolled in the early window: a post-hoc meta-analysis of individual patient data from three randomised trials
Nerinetide showed a clinically significant benefit over several outcome measures, including the modified Rankin Scale score, the incidence of stroke worsening, and infarction volumes. Neuroprotection with nerinetide might, therefore, be indicated for patients within 3 h of stroke onset and who are selected for reperfusion. These inclusion criteria should be tested in a future trial.
[Comment] Neuroprotection in acute ischaemic stroke: reasons for optimism?
The challenges of translating neuroprotective interventions with promising efficacy in animal studies into effective treatments for patients with stroke are well documented, with issues including overoptimistic therapeutic windows, poor bioavailability, and heterogeneous clinical cohorts.1,2 Yet, preservation of the ischaemic penumbra during emergency stroke care remains an attractive concept. In The Lancet Neurology, Michael Tymianski and… Continue reading [Comment] Neuroprotection in acute ischaemic stroke: reasons for optimism?
In-Ambulance Blood Test May Rapidly Identify Stroke Type
A prehospital blood test may rapidly distinguish between ischemic and hemorrhagic strokes, potentially enabling more timely, targeted treatment. Medscape Medical News