AI SummaryThe text discusses the role of microglial APOE4 in Alzheimer’s disease (AD) and its impact on the microglial response to neurodegeneration. The study shows that deletion of microglial APOE4 improves neuroprotection and decreases pathology in mouse models. It also explores the molecular mechanisms involved, such as LGALS3 signaling and ITGB8-TGFβ pathway. The findings suggest… Continue reading APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints
Tag: Neural Diseases and Disorders
Hyperbaric Oxygen Therapy for TBI: Wishful Thinking?
AI SummaryA recent review prompted a neurologist to revisit a treatment he trained in decades ago for traumatic brain injury.A recent review recommending HBOT for traumatic brain injury prompted this neurologist to revisit a treatment he trained in decades ago. Medscape Neurology
[ASAP] Resilience to Pain-Related Depression in σ1 Receptor Knockout Mice Is Associated with the Reversal of Pain-Induced Brain Changes in Affect-Related Genes
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Artificial Sweeteners in Foods Tied to Increased Depression Risk
AI SummaryRecent data shows that there may be a connection between consuming ultraprocessed food, specifically artificial sweeteners, and a higher risk of depression.New data suggest a link between ultraprocessed food, particularly artificial sweeteners, and increased depression risk. Medscape Medical News
Anxiety, Depression May Ease After Ablation Cuts AF Burden
AI SummaryResearchers acknowledge that there may be a placebo effect from AF ablation, but it is likely not the main cause of psychological benefits.One can’t say there is no placebo effect from AF ablation, but if there is, it’s probably not the main driver of psychological benefit, say researchers. Medscape Medical News
[Comment] A genetic basis for the severity of multiple sclerosis
AI SummaryMultiple sclerosis is a neurodegenerative disorder with variable outcomes. Over 200 genetic variants have been linked to the development of multiple sclerosis, mainly in genes expressed by immune cells. Current therapies target lymphocytes but some patients still experience neurological disability.Multiple sclerosis is an autoimmune, neurodegenerative disorder with highly variable long-term outcomes.1 More than 200… Continue reading [Comment] A genetic basis for the severity of multiple sclerosis
[Review] Prevention of perioperative stroke in patients undergoing non-cardiac surgery
AI SummaryApproximately 300 million adults undergo non-cardiac surgery yearly, resulting in a significant number of stroke cases. Perioperative stroke has a high mortality rate and often leads to severe disability. Covert brain infarctions, more common than overt strokes, contribute to postoperative delirium, cognitive decline, and future cerebrovascular events. Older age, hypertension, atrial fibrillation, and especially… Continue reading [Review] Prevention of perioperative stroke in patients undergoing non-cardiac surgery
[Comment] Cardiovascular disease after traumatic brain injury: the heart of the matter
AI SummaryThe Lancet Commission on dementia found that traumatic brain injury (TBI) is associated with an increased risk of dementia. Other modifiable risk factors for dementia, such as cardiovascular disease, are also linked to TBI and repetitive head impacts.The 2020 report of the Lancet Commission on dementia prevention, intervention, and care1 summarised the evidence for… Continue reading [Comment] Cardiovascular disease after traumatic brain injury: the heart of the matter
[Personal View] Long-term risk of cardiovascular disease after traumatic brain injury: screening and prevention
AI SummaryTraumatic brain injury (TBI) is common in contact sports, military personnel, and the general population. Besides neurological and psychiatric issues, studies suggest an overlooked link between TBI and chronic cardiovascular diseases. Individuals without previous health conditions who experience TBI have a higher risk of developing cardiovascular diseases.Traumatic brain injury (TBI) is highly prevalent among… Continue reading [Personal View] Long-term risk of cardiovascular disease after traumatic brain injury: screening and prevention
[Comment] Combining cognitive interventions in multiple sclerosis
AI SummaryCognitive impairment is a major issue in multiple sclerosis, affecting daily life and self-care. It is more common and severe in progressive MS, and worsens with age, fatigue, depression, and neural damage. Lifestyle and cognitive reserve also play a role.Cognitive impairment can be one of the most disabling aspects of multiple sclerosis, substantially affecting… Continue reading [Comment] Combining cognitive interventions in multiple sclerosis