Tag: Neural Diseases and Disorders

Impedance Rhythms in Human Limbic System

AI SummaryThe study found that brain tissue impedance in limbic structures (amygdala, hippocampus, anterior nucleus thalamus) exhibits oscillations over different time scales, including ultradian (~1.5-1.7 h) and circadian (~21.6-26.4 h) periods associated with sleep-wake state transitions. The impedance also shows longer oscillations that have no clear behavioral correlate. These findings suggest that impedance can be… Continue reading Impedance Rhythms in Human Limbic System

FDA Review Skeptical of ALS Stem Cell Therapy

AI SummaryThe FDA has concerns about an experimental stem cell therapy for ALS that will be discussed at a public hearing.The FDA has raised concerns about the safety and efficacy of an experimental stem cell therapy for ALS scheduled for a public hearing by a federal advisory panel on Wednesday. Medscape Medical News

No Benefit of EC/IC Bypass vs Meds in Large-Artery Stroke

AI SummaryAdding extracranial-intracranial bypass to medical therapy does not reduce stroke or death in symptomatic occlusion of the internal carotid or middle cerebral artery, according to a Medscape Medical News article.Despite surgical advances, adding extracranial-intracranial bypass to medical therapy does not reduce stroke or death in symptomatic occlusion of the internal carotid or middle cerebral… Continue reading No Benefit of EC/IC Bypass vs Meds in Large-Artery Stroke

Four McGovern Investigators receive NIH BRAIN Initiative grants

AI SummaryThe National Institutes of Health (NIH) has announced a new program to support research projects that aim to map the connections in the human brain. Four of these research projects will take place at the McGovern Institute. The projects funded by the NIH aim to generate wiring diagrams that span entire brains across multiple… Continue reading Four McGovern Investigators receive NIH BRAIN Initiative grants

Unique Study Sheds New Light on TBI, Cognitive Decline Link

AI SummaryA study shows that early adulthood traumatic brain injury is linked to cognitive decline later in life, based on research involving World War II twins.Traumatic brain injury that occurs in early adulthood is associated with cognitive decline in later life, results from a study of identical twins who served in World War II show.… Continue reading Unique Study Sheds New Light on TBI, Cognitive Decline Link

Association of APOE {varepsilon}4 Status With Long-term Declines in Odor Sensitivity, Odor Identification, and Cognition in Older US Adults

AI SummaryThe study investigated the impact of the APOE 4 allele on decline in odor sensitivity, odor identification, and cognition in older adults. The results showed that APOE 4 carriers had deficits in odor sensitivity at ages 65-69, while deficits in odor identification did not appear until ages 75-79. Odor sensitivity did not decline more… Continue reading Association of APOE {varepsilon}4 Status With Long-term Declines in Odor Sensitivity, Odor Identification, and Cognition in Older US Adults

Association of Plasma A{beta}42/A{beta}40 Ratio and Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study

AI SummaryThis study examines the relationship between plasma β-amyloid (Aβ) levels and late-onset epilepsy (LOE). The researchers found that a decrease in the ratio of Aβ42/Aβ40 from midlife to late life was associated with an increased risk of epilepsy. The findings validate the link between Aβ, hyperexcitable states, and LOE.Background and Objectives The objective of… Continue reading Association of Plasma A{beta}42/A{beta}40 Ratio and Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study

Association of Olfaction and Microstructural Integrity of Brain Tissue in Community-Dwelling Adults: Atherosclerosis Risk in Communities Neurocognitive Study

AI SummaryThis study examined the association between brain microstructural integrity and olfaction in a group of adults. The results showed that higher mean diffusivity in certain brain regions, particularly the medial temporal lobe, was associated with poorer olfaction. These associations were stronger in individuals with mild cognitive impairment. The findings suggest that neuronal integrity in… Continue reading Association of Olfaction and Microstructural Integrity of Brain Tissue in Community-Dwelling Adults: Atherosclerosis Risk in Communities Neurocognitive Study

Linking Late-Onset Epilepsy With Alzheimer Disease: Insights From Plasma Amyloid Measurements

AI SummaryLate-onset epilepsy is a growing concern, with older adults being the fastest growing demographic affected. The cause is unknown in many cases.Late-onset epilepsy, or epilepsy that begins in late adulthood, now accounts for approximately 50% of all new cases of epilepsy and is a growing public health concern. Older adults are not only the… Continue reading Linking Late-Onset Epilepsy With Alzheimer Disease: Insights From Plasma Amyloid Measurements