AI SummaryIntermittent fasting can delay cognitive decline and improve conditions like stroke and Alzheimer’s. However, the exact impact of glucose restriction, a part of intermittent fasting, is not fully understood. Researchers used 2-deoxyglucose to investigate how low glucose stimulates brain plasticity and treats stroke and Alzheimer’s.Intermittent fasting (IF) is a nutritional paradigm that forestalls cognitive… Continue reading 2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience
Tag: Neural Diseases and Disorders
[Comment] Complexity is the simple truth about Alzheimer’s disease
Few fields of medicine are as polarised as that of Alzheimer’s disease and dementia research. The debate has even taken on religious undertones, with supporters of the amyloid cascade hypothesis of Alzheimer’s disease being called baptists, and critics of this theory being called tauists (from tau, the other most probable candidate in the pathogenesis of… Continue reading [Comment] Complexity is the simple truth about Alzheimer’s disease
[Personal View] The complex pathway between amyloid β and cognition: implications for therapy
For decades, the hypothesis that brain deposition of the amyloid β protein initiates Alzheimer’s disease has dominated research and clinical trials. Targeting amyloid β is starting to produce therapeutic benefit, although whether amyloid-lowering drugs will be widely and meaningfully effective is still unclear. Despite extensive in-vivo biomarker evidence in humans showing the importance of an… Continue reading [Personal View] The complex pathway between amyloid β and cognition: implications for therapy
Making invisible therapy targets visible
AI SummaryThe lab of Edward Boyden at MIT has developed a technology called Expansion Revealing (ExR) that allows researchers to visualize molecular structures at the nanoscale level. By expanding cells using a chemical process, ExR makes previously hidden molecules accessible to fluorescent tags, enabling the study of synaptic proteins and potential targets for therapeutic interventions… Continue reading Making invisible therapy targets visible
Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer’s disease in mice
AI SummaryThe text shows that the liver may be important in the development of Alzheimer’s disease, as manipulating a specific enzyme in the liver can reduce the buildup of harmful proteins in the brain and improve cognitive abilities in animal models of the disease.How changes in peripheral organs during aging contribute to AD pathogenesis remains… Continue reading Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer’s disease in mice
Tipping points in neurodegeneration
In Alzheimer’s disease (AD), Aβ deposits form slowly, several decades before further pathological events trigger neurodegeneration and dementia. However, a substantial proportion of affected individuals remains non-demented despite AD pathology, raising questions about the underlying factors that determine the transition to clinical disease. Here, we emphasize the critical function of resilience and resistance factors, which… Continue reading Tipping points in neurodegeneration
Unraveling connections between the brain and gut
AI SummaryMIT engineers have developed a new technology that allows them to control neural circuits connecting the gut and the brain in mice using fibers embedded with various sensors and light sources. Through their experiments, they were able to manipulate the gut cells to induce feelings of fullness or reward-seeking behavior in the mice, indicating… Continue reading Unraveling connections between the brain and gut
Atlas of human brain blood vessels highlights changes in Alzheimer’s disease
AI SummaryScientists from MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL), The Picower Institute for Learning and Memory, and The Broad Institute of MIT and Harvard have created a molecular atlas of human brain vasculature and its changes in Alzheimer’s disease (AD) across six brain regions. The researchers characterized over 22,514 vascular cells from different… Continue reading Atlas of human brain blood vessels highlights changes in Alzheimer’s disease
Blood-based biomarkers for Alzheimer’s disease: Current state and future use in a transformed global healthcare landscape
AI SummaryHampel et al. review data on Alzheimer’s disease biomarkers that are close to clinical use and discuss important factors for their development and implementation.Hampel et al. review current data on blood-based biomarkers (BBBMs) for Alzheimer’s disease (AD) that are closest to clinical adoption, discussing important concepts and considerations for the development and implementation of AD… Continue reading Blood-based biomarkers for Alzheimer’s disease: Current state and future use in a transformed global healthcare landscape
From labs to the streets, experts work to defuse childhood threats to mental health
AI SummaryThreats to child mental health, such as poverty, abuse, and pollution, were discussed by experts at a symposium at MIT, who stressed the importance of science and research in addressing these issues. The speakers highlighted various mechanisms that connect early life experiences to mental health problems, as well as interventions and programs aimed at… Continue reading From labs to the streets, experts work to defuse childhood threats to mental health