AI SummaryThe wrong image was published for Figure 3 in the Original Investigation titled “Positron Emission Tomography Imaging With [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes.” The article has been corrected online.In the Original Investigation titled “Positron Emission Tomography Imaging With [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes,” which was published… Continue reading Error in Figure 3
Tag: Neural Diseases and Disorders
A Call to Action to Address Sex Differences in Alzheimer Disease Clinical Trials
This Viewpoint calls for comprehensive investigations into sex differences associated with treatments in existing Alzheimer disease and integration into future Alzheimer disease and related dementia clinical trials.
[Comment] NfL is ready for translation into paediatrics
Diagnostic and therapeutic advancements for neurological conditions will be aided by progress in biomarker research across the age span. Ultrasensitive detection assays for neurofilament light chain (NfL) have emerged as validated soluble protein measures of neuroaxonal injury.1 Abnormally elevated blood and CSF concentrations of NfL correlate with the extent of CNS injury (providing prognostic and… Continue reading [Comment] NfL is ready for translation into paediatrics
[Comment] Secondary stroke prevention: more questions than answers
Advances in the clinical management of acute stroke in the past decade have led to more people surviving and living with less disability after stroke than before. However, secondary strokes, which are often more severe than the incident stroke, remain prevalent. In The Lancet Neurology, Christopher Schwarzbach and colleagues present the results of the SANO… Continue reading [Comment] Secondary stroke prevention: more questions than answers
PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke
PLA2G2E from peri-infarct-surviving neurons metabolizes phosphatidylserine to DGLA and 15-HETrE, which triggers functional recovery after ischemic stroke. These reparative lipid mediators induce PADI4 in peri-infarct-surviving neurons to initiate neural repair-associated gene expression through histone citrullination, demonstrating brain-autonomous extensive repair capabilities through lipid metabolism.
Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition
Ziff et al. uncover widespread mRNA redistribution and mislocalization of RNA-binding proteins in ALS motor neurons. Their study highlights the potential of VCP ATPase inhibition in partially restoring mRNA and protein distribution, providing insights into ALS pathogenesis and a promising therapeutic target.
Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome
Hooshmandi et al. revealed a link between the integrated stress response (ISR) pathway and elevated general protein synthesis in fragile X syndrome (FXS). ISR is selectively suppressed in mature excitatory neurons in a mouse model of FXS, resulting in increased general protein synthesis in excitatory neurons and autism-related phenotypes.
[In Context] Preparing for disease-modifying therapies in Alzheimer’s disease
The long-awaited era of disease-modifying therapy for Alzheimer’s disease has finally arrived and will substantially impact how the disease is perceived and managed, although these new treatments will pose challenges for equitable access. The drugs closest to widespread clinical implementation are lecanemab and donanemab—intravenous monoclonal antibodies that remove β-amyloid plaques from the brain and can… Continue reading [In Context] Preparing for disease-modifying therapies in Alzheimer’s disease
[Articles] The structured ambulatory post-stroke care program for outpatient aftercare in patients with ischaemic stroke in Germany (SANO): an open-label, cluster-randomised controlled trial
AI SummaryNo differences in the incidence of vascular events were found between patients with ischaemic stroke in the intervention and control groups, despite positive effects on cardiovascular risk factors. Additional evaluation is needed to assess longer-term effects and potential benefits on stroke-related sequelae and quality of life.No differences were identified between patients with ischaemic stroke… Continue reading [Articles] The structured ambulatory post-stroke care program for outpatient aftercare in patients with ischaemic stroke in Germany (SANO): an open-label, cluster-randomised controlled trial
How Tau tangles form in the brain
AI SummaryMIT chemists have gained insight into how tangled proteins called Tau fibrils form in neurodegenerative diseases, such as Alzheimer’s. They discovered that the flexibility of one segment of the Tau protein helps the fibrils take on different shapes and that fibrils are more likely to form when the ends of the Tau protein are… Continue reading How Tau tangles form in the brain