Tag: Neural Diseases and Disorders

Rab27b Promotes Lysosomal Function and Alpha-Synuclein Clearance in Neurons

Alpha-synuclein (αsyn) is the key pathogenic protein implicated in synucleinopathies including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). In these diseases, αsyn is thought to spread between cells where it accumulates and induces pathology; however, mechanisms that drive its propagation or aggregation are poorly understood. We have previously reported that the small GTPase… Continue reading Rab27b Promotes Lysosomal Function and Alpha-Synuclein Clearance in Neurons

Increased Modulation of Low-Frequency Cardiac Rhythms on Resting-State Left Insula Alpha Oscillations in Major Depressive Disorder: Evidence from a Magnetoencephalography Study

A growing body of evidence suggests that the link between the cardiac autonomic nervous system (ANS) and the central nervous system (CNS) is crucial to the onset and development of major depressive disorder (MDD), affecting perception, cognition, and emotional processing. The bottom-up heart–brain communication pathway plays a significant role in this process. Previous studies have… Continue reading Increased Modulation of Low-Frequency Cardiac Rhythms on Resting-State Left Insula Alpha Oscillations in Major Depressive Disorder: Evidence from a Magnetoencephalography Study

Looking under the hood at the brain’s language system

As a young girl growing up in the former Soviet Union, Evelina Fedorenko PhD ’07 studied several languages, including English, as her mother hoped that it would give her the chance to eventually move abroad for better opportunities. Her language studies not only helped her establish a new life in the United States as an… Continue reading Looking under the hood at the brain’s language system