Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation

Abstract γδ T cells producing either interleukin-17A (γδ17 cells) or interferon-γ (γδIFN cells) are generated in the mouse thymus, but the molecular regulators of their peripheral functions are not fully characterized. Here we established an Il17a-GFP:Ifng-YFP double-reporter mouse strain to analyze at unprecedented depth the transcriptomes of pure γδ17 cell versus γδIFN cell populations from… Continue reading Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation

Crisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune system

Microglia/macrophages participate in the development of and recovery from experimental autoimmune encephalomyelitis (EAE), and the macrophage M1 (pro-inflammatory)/M2 (anti-inflammatory) phase transition is in…

Sex differences in demyelination

Demyelination is associated with aging and age-related neurodegenerative disorders, including Alzheimer’s disease, and has shown sex differences in prevalence. In Science, Lopez-Lee et al. find that the X-linked gene Trl7 regulates male-biased type I IFN responses in a mouse model of aging-related demyelination. In aging mice treated with a demyelinating agent, females developed more severe… Continue reading Sex differences in demyelination

snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses

Macnair and Calini et al. analyze 632,000 snRNA-seq profiles from multiple sclerosis and control brain samples, identifying distinct cellular responses in white and gray matter. They stratify MS patients into groups based on patterns of gene expression in white matter glia, suggesting different pathological processes and future personalized therapies.