This randomized clinical trial investigates whether first-line disease-modifying therapy can be safely discontinued in patients with long-term stable multiple sclerosis.
Tag: Multiple Sclerosis
Measurement of Treatment Effect in Multiple Sclerosis Clinical Trials
This decision analytical model study applies restricted mean survival time as a measure of treatment effect in 2 randomized clinical trials assessing disease-modifying treatments vs placebo in patients with progressive multiple sclerosis.
Women With MS at Risk for Peripartum Mental Illness
Having multiple sclerosis (MS) was associated with higher rates of mental illness during the peripartum period than not having MS, according to a new study. Medscape Medical News
Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation
Abstract γδ T cells producing either interleukin-17A (γδ17 cells) or interferon-γ (γδIFN cells) are generated in the mouse thymus, but the molecular regulators of their peripheral functions are not fully characterized. Here we established an Il17a-GFP:Ifng-YFP double-reporter mouse strain to analyze at unprecedented depth the transcriptomes of pure γδ17 cell versus γδIFN cell populations from… Continue reading Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation
Stop DMT in Stable Multiple Sclerosis: Yes or No?
MS patients who achieve long-term stable disease on disease-modifying therapy may want to stop their medication for varying reasons. Is it safe? What do the data show? Medscape Medical News
Decreased lymph node estrogen levels cause nonremitting progressive experimental autoimmune encephalomyelitis disease
Can MS Patients Safely Stay on DMTs During Pregnancy?
A new study revealed safe MS treatment options during pregnancy, reassuring women to balance effective care with their plans for motherhood. Medscape Medical News
Crisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune system
Microglia/macrophages participate in the development of and recovery from experimental autoimmune encephalomyelitis (EAE), and the macrophage M1 (pro-inflammatory)/M2 (anti-inflammatory) phase transition is in…
Sex differences in demyelination
Demyelination is associated with aging and age-related neurodegenerative disorders, including Alzheimer’s disease, and has shown sex differences in prevalence. In Science, Lopez-Lee et al. find that the X-linked gene Trl7 regulates male-biased type I IFN responses in a mouse model of aging-related demyelination. In aging mice treated with a demyelinating agent, females developed more severe… Continue reading Sex differences in demyelination
snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses
Macnair and Calini et al. analyze 632,000 snRNA-seq profiles from multiple sclerosis and control brain samples, identifying distinct cellular responses in white and gray matter. They stratify MS patients into groups based on patterns of gene expression in white matter glia, suggesting different pathological processes and future personalized therapies.