Tag: Multiple Sclerosis

1106 nELISA high-throughput proteomics captures immune secretomes for high-resolution phenotypic screens

Background Immune phenotypes can be extremely diverse and complex, posing both a challenge to understand them and an opportunity to target them with advanced immune engineering approaches. Unfortunately, proteomics tools that capture the breadth of possible immune responses lack the throughput and affordability to rapidly profile the large sample numbers generated to identify and characterize… Continue reading 1106 nELISA high-throughput proteomics captures immune secretomes for high-resolution phenotypic screens

860 Simultaneous profiling of one million single-cell BCRs and whole transcriptomes from diseased and healthy B cells in a single experiment using combinatorial barcoding

Background Many autoimmune diseases are characterized by aberrant B cells which play a central role in pathogenesis. Each B cell expresses a B Cell Receptor (BCR), which determines its specificity in binding to different epitopes and downstream antibody generation. For autoimmune diseases such as Type 1 Diabetes, Rheumatoid Arthritis, Multiple Sclerosis, Crohn’s and Celiac disease… Continue reading 860 Simultaneous profiling of one million single-cell BCRs and whole transcriptomes from diseased and healthy B cells in a single experiment using combinatorial barcoding

473 Multiple sclerosis relapse and immune-related adverse events outcome in patients with solid organ tumors treated with immune checkpoint inhibitors

Background Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs). Patients with autoimmune diseases, such as multiple sclerosis (MS), might have an increased risk of irAEs. This study aims to investigate the risk of MS relapses and other irAEs in MS patients treated with ICIs. Methods This single-center retrospective study was conducted by electronically… Continue reading 473 Multiple sclerosis relapse and immune-related adverse events outcome in patients with solid organ tumors treated with immune checkpoint inhibitors

How the keto diet could one day treat autoimmune disorders

Scientists have long suspected the keto diet might be able to calm an overactive immune system and help some people with diseases like multiple sclerosis. Now, they have reason to believe it could be true. Scientists have discovered that the diet makes the gut and its microbes produce two factors that attenuated symptoms of MS… Continue reading How the keto diet could one day treat autoimmune disorders

Research identifies crucial links between dietary choices and progression of multiple sclerosis

Newly published research in the journal Glia has identified crucial links between dietary choices and the progression of multiple sclerosis (MS). The study, led by Patrizia Casaccia, founding director of the Advanced Science Research Center at the CUNY Graduate Center’s (CUNY ASRC) Neuroscience Initiative and Einstein Professor of Biology and Biochemistry at the CUNY Graduate… Continue reading Research identifies crucial links between dietary choices and progression of multiple sclerosis