Tag: Multiple Sclerosis

Cleavage of VAMP2/3 Affects Oligodendrocyte Lineage Development in the Developing Mouse Spinal Cord

AI SummaryCleavage of VAMP2/3 proteins impairs the development of oligodendrocytes and myelination in mice. This study highlights the importance of VAMP2/3 in regulating the maturation of oligodendrocytes and myelin formation.In the developing and adult CNS, new oligodendrocytes (OLs) are generated from a population of cells known as oligodendrocyte precursor cells (OPCs). As they begin to… Continue reading Cleavage of VAMP2/3 Affects Oligodendrocyte Lineage Development in the Developing Mouse Spinal Cord

Association of Very Early Treatment Initiation With the Risk of Long-term Disability in Patients With a First Demyelinating Event

AI SummaryEarly treatment in patients with a first demyelinating event and early multiple sclerosis is associated with better long-term outcomes. This study assessed the association between receiving very early treatment and the risk of long-term disability, including magnetic resonance findings. The results showed that very early treatment decreased the risk of disability progression and disease… Continue reading Association of Very Early Treatment Initiation With the Risk of Long-term Disability in Patients With a First Demyelinating Event

Early Treatment for Multiple Sclerosis: Time Is Brain

AI SummaryAdvancements in clinical trials have resulted in many treatment options for MS, but the best practices for using these treatments are still being researched and debated, particularly in regards to when and how to start disease-modifying therapies.Over the past decades, clinical trial successes have led to a profusion of treatment options for multiple sclerosis… Continue reading Early Treatment for Multiple Sclerosis: Time Is Brain

[Comment] A genetic basis for the severity of multiple sclerosis

AI SummaryMultiple sclerosis is a neurodegenerative disorder with variable outcomes. Over 200 genetic variants have been linked to the development of multiple sclerosis, mainly in genes expressed by immune cells. Current therapies target lymphocytes but some patients still experience neurological disability.Multiple sclerosis is an autoimmune, neurodegenerative disorder with highly variable long-term outcomes.1 More than 200… Continue reading [Comment] A genetic basis for the severity of multiple sclerosis

[Comment] Combining cognitive interventions in multiple sclerosis

AI SummaryCognitive impairment is a major issue in multiple sclerosis, affecting daily life and self-care. It is more common and severe in progressive MS, and worsens with age, fatigue, depression, and neural damage. Lifestyle and cognitive reserve also play a role.Cognitive impairment can be one of the most disabling aspects of multiple sclerosis, substantially affecting… Continue reading [Comment] Combining cognitive interventions in multiple sclerosis

[Articles] Cognitive rehabilitation and aerobic exercise for cognitive impairment in people with progressive multiple sclerosis (CogEx): a randomised, blinded, sham-controlled trial

AI SummaryCombined cognitive rehabilitation and exercise did not improve processing speed in individuals with progressive multiple sclerosis. However, further studies comparing interventions to a non-intervention group are needed to determine if meaningful improvements in processing speed are possible.Combined cognitive rehabilitation plus exercise does not seem to improve processing speed in people with progressive multiple sclerosis.… Continue reading [Articles] Cognitive rehabilitation and aerobic exercise for cognitive impairment in people with progressive multiple sclerosis (CogEx): a randomised, blinded, sham-controlled trial

Unveiling the role of EBV in the onset and progression of multiple sclerosis

AI SummaryAn international research team is investigating the connection between the Epstein-Barr virus (EBV) and the development of multiple sclerosis (MS). They aim to understand why only some EBV-infected people develop MS, and to uncover the underlying mechanism. The team is conducting clinical trials to test antiviral therapies and will analyze blood and saliva samples.… Continue reading Unveiling the role of EBV in the onset and progression of multiple sclerosis

Examining the National Representativeness of the Axon Registry: A Neurology-Specific Patient Registry

AI SummaryThe text discusses a study that compared the Axon Registry, a data registry for neurology providers, with two publicly available data sets. The study found that the Axon Registry had similar demographics and neurologic conditions compared to the national data sets. The study suggests that recruiting more and diverse neurology providers will improve the… Continue reading Examining the National Representativeness of the Axon Registry: A Neurology-Specific Patient Registry

Pearls & Oy-sters: CSF1R-Related Leukoencephalopathy With Spinal Cord Lesions Mimicking Multiple Sclerosis

AI SummaryThe text describes a case of an autosomal dominant neurologic disorder called CSF1R-related leukoencephalopathy, which causes various neurologic complications. The case report emphasizes the importance of considering adult-onset neurogenetic disorders in cases of white matter disease and using genetic testing for diagnosis and treatment decisions.CSF1R-related leukoencephalopathy is an autosomal dominant neurologic disorder causing microglial… Continue reading Pearls & Oy-sters: CSF1R-Related Leukoencephalopathy With Spinal Cord Lesions Mimicking Multiple Sclerosis