AI SummaryThis study compares the prices of ocrelizumab and rituximab to see how much Medicare and Medicaid could save by using rituximab for multiple sclerosis treatment instead.This cross-sectional study compares price data for ocrelizumab and rituximab to estimate the savings to Medicare and Medicaid if rituximab were used in the treatment of multiple sclerosis instead… Continue reading Potential Medicare and Medicaid Savings on Anti-CD20 Therapy for Multiple Sclerosis
Tag: Multiple Sclerosis
Error in Figure 2B
In the Original Investigation titled “Immunoglobulin A Antibodies Against Myelin Oligodendrocyte Glycoprotein in a Subgroup of Patients With Central Nervous System Demyelination,” which was published September 1, 2023, the second pair of bars in Figure 2B was inverted. The article was corrected online.
Europe Revokes Marketing Authorization for Generic Versions of Biogen’s MS Drug
Biogen Inc said on Tuesday the European Commission has revoked the marketing authorization for generic versions of its multiple sclerosis drug Tecfidera held by the firms… Reuters Health Information
Depression, Constipation, UTIs Early Signs of MS?
AI SummaryCertain symptoms such as depression and urinary issues may occur before a diagnosis of multiple sclerosis.Depression, constipation, cystitis, urinary tract infections, and sexual dysfunction may precede a diagnosis of multiple sclerosis by 5 years, new research shows. Medscape Medical News
[Review] Blood–brain barrier dysfunction in multiple sclerosis: causes, consequences, and potential effects of therapies
AI SummaryThe blood-brain barrier regulates molecules and immune cell entry into the CNS, and plays a role in cerebral blood flow regulation. In multiple sclerosis, BBB damage and immune cell infiltration occur in the early stages, while dysregulation of neurovascular coupling is associated with grey matter atrophy in later stages.Established by brain endothelial cells, the… Continue reading [Review] Blood–brain barrier dysfunction in multiple sclerosis: causes, consequences, and potential effects of therapies
Quality of Life in Patients With Confirmed and Suspected Spinal CSF Leaks
Background and Objectives Spontaneous intracranial hypotension (SIH) is a debilitating condition typically producing orthostatic headache limiting upright time. SIH is often difficult to diagnose and treat, negatively affecting quality of life (QoL) in patients with the disorder. We studied QoL in patients with confirmed and suspected SIH using standardized instruments, including suicidality. Methods We performed… Continue reading Quality of Life in Patients With Confirmed and Suspected Spinal CSF Leaks
Agreement Between Published Reference Resources for Neurofilament Light Chain Levels in People With Multiple Sclerosis
AI SummaryThe text discusses a study that examined the agreement between different reference resources for neurofilament light chain (NfL) in a large population of people with multiple sclerosis (MS). The study found that the classification of NfL measurements as elevated varied depending on the reference resource used, indicating the need for standardization in NfL measurement… Continue reading Agreement Between Published Reference Resources for Neurofilament Light Chain Levels in People With Multiple Sclerosis
Ongoing Challenges in the Diagnosis of MOGAD
This cross-sectional study examines whether proposed myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) diagnostic criteria can exclude other diseases, such as multiple sclerosis, and rely on results of cell-based assays.
Neurofilament Light Chain Elevation and Disability Progression in Multiple Sclerosis
This cohort study investigates the timing of neuroaxonal pathology in individuals with multiple sclerosis who experience disability worsening.
Intestinal epithelial dopamine receptor signaling drives sex-specific disease exacerbation in a mouse model of multiple sclerosis
Central nervous system (CNS) autoimmunity has a strong female bias, but the underlying biology is not well understood. Here, Peng et al. demonstrate that female-specific hyperactivity of intestinal epithelial dopamine D2 receptors alters gut microbial composition and metabolites, consequently promoting microglial activation and sex-selective vulnerability to CNS autoimmune diseases.