AI SummaryThe text describes a case of an autosomal dominant neurologic disorder called CSF1R-related leukoencephalopathy, which causes various neurologic complications. The case report emphasizes the importance of considering adult-onset neurogenetic disorders in cases of white matter disease and using genetic testing for diagnosis and treatment decisions.CSF1R-related leukoencephalopathy is an autosomal dominant neurologic disorder causing microglial… Continue reading Pearls & Oy-sters: CSF1R-Related Leukoencephalopathy With Spinal Cord Lesions Mimicking Multiple Sclerosis
Tag: Multiple Sclerosis
Effects of Ibudilast on Retinal Atrophy in Progressive Multiple Sclerosis Subtypes: Post Hoc Analyses of the SPRINT-MS Trial
Background and Objectives Ganglion cell + inner plexiform layer (GCIPL) thinning, measured by optical coherence tomography (OCT), reflects global neurodegeneration in multiple sclerosis (MS). Atrophy of the inner (INL) and outer nuclear layer (ONL) may also be prominent in progressive MS (PMS). The phase 2, SPRINT-MS trial found reduced brain atrophy with ibudilast therapy in… Continue reading Effects of Ibudilast on Retinal Atrophy in Progressive Multiple Sclerosis Subtypes: Post Hoc Analyses of the SPRINT-MS Trial
Optical Coherence Tomography, Retinal Atrophy, and Neurodegeneration in Progressive Multiple Sclerosis: Sprinting to the Finish
AI SummaryOptical coherence tomography (OCT) is a useful tool for assessing damage to the optic nerve and retina. It has been particularly beneficial in understanding multiple sclerosis (MS), where measurements of retinal thickness have been correlated with visual function and disability. However, there have been inconsistent results in studies on progressive forms of MS, which… Continue reading Optical Coherence Tomography, Retinal Atrophy, and Neurodegeneration in Progressive Multiple Sclerosis: Sprinting to the Finish
Myelin Oligodendrocyte Glycoprotein–IgA in a Subgroup of Patients With Central Nervous System Demyelination
This cross-sectional study examines laboratory and imaging data for patients with demyelinating central nervous system disease to investigate the frequency of MOG-IgA and associated clinical features.
New Approaches to Challenge Old Assumptions—B-Cell Depletion in Multiple Sclerosis
B-cell–depleting monoclonal antibodies (mAbs) have emerged as an arguably mechanistically dominant drug class in the multiple sclerosis (MS) disease-modifying therapy (DMT) armamentarium in recent years. As a group, they represent a high-efficacy treatment option for relapsing MS and offer some degree of efficacy in progressive forms of MS. Ocrelizumab remains the only DMT approved for… Continue reading New Approaches to Challenge Old Assumptions—B-Cell Depletion in Multiple Sclerosis
Initiation Patterns of Disease-Modifying Therapies for Multiple Sclerosis Among US Adults and Children, 2001-2020
This study evaluates patterns in disease-modifying therapy initiations between 2001 and 2020 among commercially insured US adults and children with multiple sclerosis.
Rituximab vs Ocrelizumab in Relapsing-Remitting Multiple Sclerosis
AI SummaryThis cohort study compares the effectiveness of rituximab and ocrelizumab in preventing relapses and disability in patients with relapsing-remitting multiple sclerosis.This cohort study investigates if rituximab is noninferior to ocrelizumab in the prevention of relapses and disability in patients with relapsing-remitting multiple sclerosis.
[Comment] NfL is ready for translation into paediatrics
Diagnostic and therapeutic advancements for neurological conditions will be aided by progress in biomarker research across the age span. Ultrasensitive detection assays for neurofilament light chain (NfL) have emerged as validated soluble protein measures of neuroaxonal injury.1 Abnormally elevated blood and CSF concentrations of NfL correlate with the extent of CNS injury (providing prognostic and… Continue reading [Comment] NfL is ready for translation into paediatrics
Atlas of human brain blood vessels highlights changes in Alzheimer’s disease
AI SummaryScientists from MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL), The Picower Institute for Learning and Memory, and The Broad Institute of MIT and Harvard have created a molecular atlas of human brain vasculature and its changes in Alzheimer’s disease (AD) across six brain regions. The researchers characterized over 22,514 vascular cells from different… Continue reading Atlas of human brain blood vessels highlights changes in Alzheimer’s disease
[In Context] Kerstin Hellwig: educating on multiple sclerosis and pregnancy
AI SummaryKerstin Hellwig, a clinician-scientist, had various aspirations as a child before settling on becoming a doctor. She now specializes in multiple sclerosis and pregnancy. Hellwig is the chair and founder of the German multiple sclerosis and pregnancy registry and has a private practice.When Kerstin Hellwig was 3 years old, she wanted to become a… Continue reading [In Context] Kerstin Hellwig: educating on multiple sclerosis and pregnancy