Science Immunology, Volume 10, Issue 104, February 2025.
Tag: Multiple Sclerosis
[In Context] Maria Trojano: advocate for real-world multiple sclerosis studies
Maria Trojano describes herself as “a strong-willed person” who has always enjoyed solving problems. For her, neurology seems a perfect fit. “Neurology is still one of those fields where you have to use history, information, and examination to arrive at the clinical diagnosis. So you have to solve problems every day”, she says. Trojano is… Continue reading [In Context] Maria Trojano: advocate for real-world multiple sclerosis studies
Multiple sclerosis: Cell-catching implant helps identify successful treatment in mice
A sponge-like implant in mice helped guide a treatment that slowed or stopped a degenerative condition similar to multiple sclerosis in humans. It also gave researchers a look at how primary progressive multiple sclerosis, the fastest-progressing version of the disease, attacks the central nervous system early on.
Engineered immunological niche directs therapeutic development in models of progressive multiple sclerosis
Discontinuation of First-Line Disease-Modifying Therapy in Patients With Stable Multiple Sclerosis
This randomized clinical trial investigates whether first-line disease-modifying therapy can be safely discontinued in patients with long-term stable multiple sclerosis.
Measurement of Treatment Effect in Multiple Sclerosis Clinical Trials
This decision analytical model study applies restricted mean survival time as a measure of treatment effect in 2 randomized clinical trials assessing disease-modifying treatments vs placebo in patients with progressive multiple sclerosis.
Women With MS at Risk for Peripartum Mental Illness
Having multiple sclerosis (MS) was associated with higher rates of mental illness during the peripartum period than not having MS, according to a new study. Medscape Medical News
Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation
Abstract γδ T cells producing either interleukin-17A (γδ17 cells) or interferon-γ (γδIFN cells) are generated in the mouse thymus, but the molecular regulators of their peripheral functions are not fully characterized. Here we established an Il17a-GFP:Ifng-YFP double-reporter mouse strain to analyze at unprecedented depth the transcriptomes of pure γδ17 cell versus γδIFN cell populations from… Continue reading Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation
Stop DMT in Stable Multiple Sclerosis: Yes or No?
MS patients who achieve long-term stable disease on disease-modifying therapy may want to stop their medication for varying reasons. Is it safe? What do the data show? Medscape Medical News