Downmodulation of Potassium Conductances Induces Epileptic Seizures in Cortical Network Models Via Multiple Synergistic Factors

Voltage-gated potassium conductances gK play a critical role not only in normal neural function, but also in many neurological disorders and related therapeutic interventions. In particular, in an important animal model of epileptic seizures, 4-aminopyridine (4-AP) administration is thought to induce seizures by reducing gK in cortex and other brain areas. Interestingly, 4-AP has also… Continue reading Downmodulation of Potassium Conductances Induces Epileptic Seizures in Cortical Network Models Via Multiple Synergistic Factors

[Personal View] Multiple sclerosis and COVID-19: interactions and unresolved issues

Serious symptomatic SARS-CoV-2 infection and COVID-19 complications are particular concerns for people with multiple sclerosis, especially those receiving immunosuppressants or immunomodulators. Studies have aimed to identify individuals with multiple sclerosis who are at high risk for SARS-CoV-2 infection, to analyse the interplay between SARS-CoV-2 and multiple sclerosis and to evaluate immunological responses to SARS-CoV-2 infection… Continue reading [Personal View] Multiple sclerosis and COVID-19: interactions and unresolved issues

[Comment] SARS-CoV-2 infection in people with multiple sclerosis

The risk for severe COVID-19 and associated complications remains a concern for people with multiple sclerosis, particularly those receiving immunosuppressive or immunomodulatory therapies. In their Personal View1 in The Lancet Neurology, Ana Zabalza and colleagues provide an in-depth update regarding the knowledgebase on the identification of patients with multiple sclerosis at highest risk for adverse… Continue reading [Comment] SARS-CoV-2 infection in people with multiple sclerosis