A new study revealed safe MS treatment options during pregnancy, reassuring women to balance effective care with their plans for motherhood. Medscape Medical News
Tag: Multiple Sclerosis
Crisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune system
Microglia/macrophages participate in the development of and recovery from experimental autoimmune encephalomyelitis (EAE), and the macrophage M1 (pro-inflammatory)/M2 (anti-inflammatory) phase transition is in…
Sex differences in demyelination
Demyelination is associated with aging and age-related neurodegenerative disorders, including Alzheimer’s disease, and has shown sex differences in prevalence. In Science, Lopez-Lee et al. find that the X-linked gene Trl7 regulates male-biased type I IFN responses in a mouse model of aging-related demyelination. In aging mice treated with a demyelinating agent, females developed more severe… Continue reading Sex differences in demyelination
The Challenges of Modulating Neuroinflammation in Alzheimer’s Disease and Multiple Sclerosis with TREM2 Agonistic Antibodies
Connecting the dots: Presentation of EBV antigens on HLA class II risk alleles connects the two main risk factors of multiple sclerosis
MS Care for Aging Patients: Best Practices
Dr Jennifer Graves shares clinical insights for managing older patients with multiple sclerosis. Consortium of Multiple Sclerosis Centers
Less Fatigue in Multiple Sclerosis With CBT and Modafinil
Modafinil and cognitive behavioral therapy, either alone or in combination, were associated with significantly less fatigue in patients with multiple sclerosis. Medscape Medical News
1106 nELISA high-throughput proteomics captures immune secretomes for high-resolution phenotypic screens
Background Immune phenotypes can be extremely diverse and complex, posing both a challenge to understand them and an opportunity to target them with advanced immune engineering approaches. Unfortunately, proteomics tools that capture the breadth of possible immune responses lack the throughput and affordability to rapidly profile the large sample numbers generated to identify and characterize… Continue reading 1106 nELISA high-throughput proteomics captures immune secretomes for high-resolution phenotypic screens
860 Simultaneous profiling of one million single-cell BCRs and whole transcriptomes from diseased and healthy B cells in a single experiment using combinatorial barcoding
Background Many autoimmune diseases are characterized by aberrant B cells which play a central role in pathogenesis. Each B cell expresses a B Cell Receptor (BCR), which determines its specificity in binding to different epitopes and downstream antibody generation. For autoimmune diseases such as Type 1 Diabetes, Rheumatoid Arthritis, Multiple Sclerosis, Crohn’s and Celiac disease… Continue reading 860 Simultaneous profiling of one million single-cell BCRs and whole transcriptomes from diseased and healthy B cells in a single experiment using combinatorial barcoding
473 Multiple sclerosis relapse and immune-related adverse events outcome in patients with solid organ tumors treated with immune checkpoint inhibitors
Background Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs). Patients with autoimmune diseases, such as multiple sclerosis (MS), might have an increased risk of irAEs. This study aims to investigate the risk of MS relapses and other irAEs in MS patients treated with ICIs. Methods This single-center retrospective study was conducted by electronically… Continue reading 473 Multiple sclerosis relapse and immune-related adverse events outcome in patients with solid organ tumors treated with immune checkpoint inhibitors