Voltage-gated potassium conductances gK play a critical role not only in normal neural function, but also in many neurological disorders and related therapeutic interventions. In particular, in an important animal model of epileptic seizures, 4-aminopyridine (4-AP) administration is thought to induce seizures by reducing gK in cortex and other brain areas. Interestingly, 4-AP has also… Continue reading Downmodulation of Potassium Conductances Induces Epileptic Seizures in Cortical Network Models Via Multiple Synergistic Factors
Tag: Multiple Sclerosis
Improving Cognitive Outcomes in Multiple Sclerosis
Drs Frederick Foley and John DeLuca share clinical insights for the assessment and treatment of cognitive dysfunction in multiple sclerosis. Consortium of Multiple Sclerosis Centers
Neurology Patient Frailty: A Clinician’s Guide
Frailty is a complex syndrome that may be under-recognized yet can complicate the clinical trajectory of neurologic diseases like dementia, Parkinson’s, multiple sclerosis, and stroke. Medscape Medical News
Acute TREM2 inhibition depletes MAFB-high microglia and hinders remyelination
Conference MDAngle: AAN 2025 Relapsing-Remitting Multiple Sclerosis
Dr Pavan Bhargava shares AAN 2025 highlights, including anticipated presentations, quick takeaways, and insights into how new research in RRMS affects his patients. Medscape
Communicating a New Diagnosis of Multiple Sclerosis
Dr Shiv Saidha of Johns Hopkins University and his patient discuss strategies to convey a new diagnosis of multiple sclerosis and to foster shared decision-making for optimal disease management. Medscape
Disease-Modifying Therapies for RRMS From ACTRIMS 2025
Updates on therapies for relapsing-remitting MS from ACTRIMS 2025 include the effects of B-cell-depleting agents in minority populations and a novel approach utilizing CAR T-cells to target CD19. Medscape
Can CVS Help Distinguish MS From Its Most Common Mimic?
Using 3T MRI to analyze central vein counts and distribution in white matter lesions allows investigators to distinguish multiple sclerosis from migraine pathology. Medscape Medical News
[Personal View] Multiple sclerosis and COVID-19: interactions and unresolved issues
Serious symptomatic SARS-CoV-2 infection and COVID-19 complications are particular concerns for people with multiple sclerosis, especially those receiving immunosuppressants or immunomodulators. Studies have aimed to identify individuals with multiple sclerosis who are at high risk for SARS-CoV-2 infection, to analyse the interplay between SARS-CoV-2 and multiple sclerosis and to evaluate immunological responses to SARS-CoV-2 infection… Continue reading [Personal View] Multiple sclerosis and COVID-19: interactions and unresolved issues
[Comment] SARS-CoV-2 infection in people with multiple sclerosis
The risk for severe COVID-19 and associated complications remains a concern for people with multiple sclerosis, particularly those receiving immunosuppressive or immunomodulatory therapies. In their Personal View1 in The Lancet Neurology, Ana Zabalza and colleagues provide an in-depth update regarding the knowledgebase on the identification of patients with multiple sclerosis at highest risk for adverse… Continue reading [Comment] SARS-CoV-2 infection in people with multiple sclerosis