Dolutegravir is recommended for all people living with HIV because of its efficacy, high barrier to resistance, favourable safety and tolerability profile . It has been associated with metabolic complications, including weight gain and rare events of hyperglycaemia, that could affect maternal, fetal, and postnatal health .
Tag: Metabolic Pathways
A cool path to disease deceleration
In 2020, Kathrin “Kat” Kajderowicz’s father passed away from lung cancer. Kajderowicz was in charge of her father’s health care for as long as she can remember. While he suffered from various cardiovascular issues for several years, it wasn’t until the beginning of the Covid-19 pandemic that he was diagnosed with late-stage metastatic small-cell lung… Continue reading A cool path to disease deceleration
Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer’s disease
AI SummaryThe authors suppressed γ-secretase in human neurons and observed changes in synaptic activity and number. They found that γ-secretase regulates neurotransmitter release through the regulation of cholesterol levels.Essayan-Perez and Südhof chronically suppressed γ-secretase in human-induced neurons to record their synaptic activity and image their synapses. They show that γ-secretase regulates the probability of neurotransmitter… Continue reading Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer’s disease
PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke
PLA2G2E from peri-infarct-surviving neurons metabolizes phosphatidylserine to DGLA and 15-HETrE, which triggers functional recovery after ischemic stroke. These reparative lipid mediators induce PADI4 in peri-infarct-surviving neurons to initiate neural repair-associated gene expression through histone citrullination, demonstrating brain-autonomous extensive repair capabilities through lipid metabolism.
Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer’s disease in mice
AI SummaryThe text shows that the liver may be important in the development of Alzheimer’s disease, as manipulating a specific enzyme in the liver can reduce the buildup of harmful proteins in the brain and improve cognitive abilities in animal models of the disease.How changes in peripheral organs during aging contribute to AD pathogenesis remains… Continue reading Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer’s disease in mice
Atlas of human brain blood vessels highlights changes in Alzheimer’s disease
AI SummaryScientists from MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL), The Picower Institute for Learning and Memory, and The Broad Institute of MIT and Harvard have created a molecular atlas of human brain vasculature and its changes in Alzheimer’s disease (AD) across six brain regions. The researchers characterized over 22,514 vascular cells from different… Continue reading Atlas of human brain blood vessels highlights changes in Alzheimer’s disease
New technologies reveal cross-cutting breakdowns in Alzheimer’s disease
After decades of fundamental scientific and drug discovery research, Alzheimer’s disease has remained inscrutable and incurable, with a bare minimum of therapeutic progress. But in a new review article in Nature Neuroscience, MIT scientists write that by employing the new research capability of single-cell profiling, the field has rapidly achieved long-sought insights with strong potential for both… Continue reading New technologies reveal cross-cutting breakdowns in Alzheimer’s disease
Professor Emeritus Richard Wurtman, influential figure in translational research, dies at 86
AI SummaryRichard Wurtman, a prominent neurochemist and neuropharmacologist who was a member of the MIT faculty for 44 years, has died at the age of 86. Wurtman’s research on neurotransmitters and the impact of nutrition on brain function has made significant contributions to our understanding of conditions such as Alzheimer’s disease and premenstrual syndrome. He… Continue reading Professor Emeritus Richard Wurtman, influential figure in translational research, dies at 86
Alzheimer’s risk gene undermines insulation of brain’s “wiring”
AI SummaryA new study published in Nature by an MIT-based team provides insight into how the APOE4 gene variant increases the risk for Alzheimer’s disease. The study shows that APOE4 disrupts the management of cholesterol in brain cells called oligodendrocytes, leading to a deficiency in the fatty insulation of neurons known as myelin, which impairs… Continue reading Alzheimer’s risk gene undermines insulation of brain’s “wiring”
Are Covid-19 “comas” signs of a protective hibernation state?
AI SummaryMany Covid-19 patients who have been treated with mechanical ventilation are slow to regain consciousness even after being taken off sedation, and a new study suggests that this could be due to a hibernation-like state induced by the brain to protect cells during periods of oxygen scarcity. This state has been observed in other… Continue reading Are Covid-19 “comas” signs of a protective hibernation state?