AI SummaryThis content is an episode (TWiV 1147) of the podcast “This Week in Virology” where the hosts review various topics including a multi-country outbreak of Mpox, the first face-covering ban in Nassau County NY, a case of polio in India, and factors contributing to newborn vulnerability to norovirus diarrhea, specifically related to breastmilk. The… Continue reading TWiV 1147: Breastmilk paradox for norovirus
Tag: Metabolic Pathways
Outcomes of radiofrequency ablation for hepatocellular carcinoma with concurrent steatotic liver disease
AI SummaryThis study investigated the impact of steatotic liver disease (SLD) on the outcomes of patients with hepatocellular carcinoma (HCC) undergoing radiofrequency ablation (RFA) therapy. The analysis found that patients with concurrent SLD had a lower risk of all-cause mortality compared to those with poor liver functional reserve. Good liver function maintenance was identified as… Continue reading Outcomes of radiofrequency ablation for hepatocellular carcinoma with concurrent steatotic liver disease
Pre-vax metabolic clues: Cracking the code to a better dengue vaccine
Science Immunology, Volume 9, Issue 99, September 2024.
Association between Inhibitory-Excitatory Balance and Brain Activity Response during Cognitive Flexibility in Young and Older Individuals
AI SummaryThe study focuses on the association between inhibitory-excitatory balance in the left inferior frontal cortex (IFC) and left inferior parietal lobule (IPL) and brain activity response during cognitive flexibility in young and older individuals. Results indicate differences in metabolic mechanisms underlying cognitive flexibility in the two age groups, with implications for executive functioning and… Continue reading Association between Inhibitory-Excitatory Balance and Brain Activity Response during Cognitive Flexibility in Young and Older Individuals
Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming
Lag3 is a co-inhibitory receptor expressed on T cells, including Foxp3+ regulatory T cells. However, the mechanism underlying Lag3 functions in Treg cells remains largely unclear. Kim et al. generated Treg-specific Lag3 mutant mice and reported that Lag3 supports Treg cell function by inhibiting Myc expression and altering metabolic profiles through the PI3K-Akt-Rictor pathway.
Impacts beyond the brain: Unraveling molecular mechanisms linking psychiatric, metabolic, and inflammatory conditions
AI SummaryThe article discusses how the expression of semaphorin 6D in the amygdala plays a central role in coordinating brain, metabolic, and immunologic functions. This research sheds light on how deficiencies in the brain can affect physiological systems beyond the brain, linking psychiatric, metabolic, and inflammatory conditions.By establishing semaphorin 6D expression in the amygdala as… Continue reading Impacts beyond the brain: Unraveling molecular mechanisms linking psychiatric, metabolic, and inflammatory conditions
[ASAP] A Cyclometalated Iridium(III) Complex Exerts High Anticancer Efficacy via Fatty Acid Beta-Oxidation Inhibition and Sphingolipid Metabolism Reprogramming
AI SummarySummary: The article discusses a cyclometalated iridium(III) complex that demonstrates high efficacy in fighting cancer by inhibiting fatty acid beta-oxidation and reprogramming sphingolipid metabolism. The complex shows promise as a potential anticancer agent.
Immune Booster #8: Immunology, metabolism, and exercise physiology with Heather Caslin
From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Heather Caslin to talk about her training and the research of her laboratory on how diet and exercise affect innate immune cells in health and disease. Hosts: Cindy Leifer and Brianne Barker Guest: Heather Caslin Click arrow to playDownload Immune Booster… Continue reading Immune Booster #8: Immunology, metabolism, and exercise physiology with Heather Caslin
Fecal Microbiome Transplants For Parkinson Disease
AI SummaryThis content discusses the use of fecal microbiome transplants (FMT) for Parkinson disease (PD). The gastrointestinal tract contains various microbes that impact health and disease through metabolic, immunologic, and neurosensory pathways. The gut microbiome has been identified as a potential target for various diseases, including PD. Recent studies, including one by Scheperjans et al,… Continue reading Fecal Microbiome Transplants For Parkinson Disease
Editors’ Picks, August 2024: ‘Colon Age’ Screening Recs, Stress From Violence, and More
AI SummaryThis article highlights the Editors’ Picks from August 2024 for the American Association for Cancer Research (AACR). The selections include topics such as a new metric called “Colon Age” for early-onset colorectal cancer screening, the relationship between exposure to neighborhood violence and glucocorticoid receptor signaling in lung tumors, and the development of a CD33-targeting… Continue reading Editors’ Picks, August 2024: ‘Colon Age’ Screening Recs, Stress From Violence, and More