Scientists uncover an enzyme that boosts cancer cell metabolism to fuel growth. The enzyme, GUK1, supports metabolism in cancer cells to help tumors grow.
Tag: Metabolic Pathways
Metabolite signaling promotes the recruitment of immunosuppressive cells to tumors
Metabolite-sensing G protein-coupled receptors act as critical signaling hubs that connect metabolism to immunity in cancer. Here we show that activation of the lactate receptor HCAR1 in colorectal tumor cells leads to the recruitment of immunosuppressive PMN-MDSCs to tumors, thereby impairing anti-tumor immunity and diminishing the effectiveness of immunotherapies. This is a preview of subscription… Continue reading Metabolite signaling promotes the recruitment of immunosuppressive cells to tumors
Deficiency of adenosine deaminase 2 skews adaptive immune repertoires towards specific sets of T and B cell receptors
Impact of hepatic steatosis on the efficacy of antiviral treatment for chronic hepatitis B and the establishment of predictive model: a cohort study
Metabolic dysfunction-associated steatotic disease (MASLD) and chronic hepatitis B (CHB) are prevalent liver disorders. Ongoing discussions investigate the impact of MASLD on the therapeutic outcomes of CHB. Continue reading on BioMed Central
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibition of NLRP3 increases glutamine utilization and α-ketoglutarate, which triggers downstream epigenetic changes allowing acetylation of target phagocytic and metabolic genes. This microglial reprogramming has implications for dementia and AD therapies.