Tag: Metabolic Pathways

Glut3 overexpression improves environmental glucose uptake and antitumor efficacy of CAR-T cells in solid tumors

Background Glucose deprivation inhibits T-cell metabolism and function. Glucose levels are low in the tumor microenvironment of solid tumors and insufficient glucose uptake limits the antitumor response of T cells. Furthermore, glucose restriction can contribute to the failure of chimeric antigen receptor T (CAR-T) cell therapy for solid tumors. However, the impact of glucose restriction… Continue reading Glut3 overexpression improves environmental glucose uptake and antitumor efficacy of CAR-T cells in solid tumors

SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease

Alzheimer’s Disease (AD) is a neurodegenerative disease with drastically altered astrocytic metabolism. Astrocytic GABA and H2O2 are associated with memory impairment in AD and synthesized through the Monoamine O…

TWiV 1183: More than 2024 viruses

TWiV reviews some of their favorite virology stories from 2024. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Click arrow to playDownload TWiV 1183 (66 MB .mp3, 111 min) Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 SARS-CoV-2 origins (TWiV Special) TWiV 1163: Hepadnaviridae in the… Continue reading TWiV 1183: More than 2024 viruses

Experts Forecast Cancer Research and Treatment Advances in 2025

Every new year brings excitement and anticipation for what might happen over the next 12 months. So, what’s in store for 2025 that could change the way we diagnose and treat cancer? What first-in-class therapeutics could offer new life-saving options to patients? What scientific discovery will have everyone talking?  In 2024, we saw the approval… Continue reading Experts Forecast Cancer Research and Treatment Advances in 2025

SABCS Session Provides Clinical Implications of New Data and Practical Takeaways

The 2024 San Antonio Breast Cancer Symposium (SABCS) concluded with a “View from the Trenches” panel discussing the clinical implications of key findings presented during the symposium. Bringing medical, surgical, and radiation oncology specialists together with a breast cancer thriver turned patient advocate, the conversation explored how these latest findings might alter how clinicians navigate… Continue reading SABCS Session Provides Clinical Implications of New Data and Practical Takeaways

Gut microbes and the body work together to regulate fat metabolism

Beneficial gut microbes and the body work together to fine-tune fat metabolism and cholesterol levels, according to a new preclinical study by investigators from Weill Cornell Medicine and the Boyce Thompson Institute at Cornell University’s Ithaca campus. The human body has co-evolved with the beneficial microbes that live in the gut (termed the microbiota), resulting… Continue reading Gut microbes and the body work together to regulate fat metabolism