Metabolic storage disorders, including lysosomal storage disorders, pose complex challenges in management due to their progressive and life-threatening nature. Although enzyme replacement therapy has substantially improved outcomes for patients with lysosomal storage disorders, limitations of this therapy have become apparent throughout two decades of use. New clinical features of these diseases have emerged as patients… Continue reading [Review] Clinical insights in enzyme replacement therapy for metabolic storage disorders: lessons from Pompe disease
Tag: Metabolic Pathways
[ASAP] Metabolic Engineering of Corynebacterium glutamicum for Producing Different Types of Triterpenoids
Cryo-EM of native membranes reveals an intimate connection between the Krebs cycle and aerobic respiration in mycobacteria
PCSK9 potentiates innate immune response to RNA viruses by preventing AIP4-mediated polyubiquitination and degradation of VISA/MAVS
Oral vancomycin induces PSC-IBD remission, driving gut microbiome and metabolic shifts
A four-week treatment with oral vancomycin led to clinical remission in PSC-IBD patients, accompanied by significant shifts in gut microbiota, reduced inflammation, and altered bile acid and short-chain fatty acid metabolism—effects that reversed upon treatment withdrawal. Study: Open label vancomycin in primary sclerosing cholangitis-inflammatory bowel disease: improved colonic disease activity and associations with changes in host-microbiome-metabolomic… Continue reading Oral vancomycin induces PSC-IBD remission, driving gut microbiome and metabolic shifts
Estimating cancer incidence attributable to physical inactivity in the United States
Abstract Background Previous estimates of the number of cancers attributable to physical inactivity in the United States have typically focused on only three malignancies (colon, endometrial, and postmenopausal breast cancer). Contemporary epidemiologic evidence suggests that physical inactivity could contribute to up to 15 types of cancer, and a dose–response effect has been demonstrated for 13… Continue reading Estimating cancer incidence attributable to physical inactivity in the United States
[ASAP] De Novo Production of 1,6-Hexanediol and 1,6-Hexamethylenediamine from Glucose by Metabolic Engineered Escherichia coli
Estimating cancer incidence attributable to physical inactivity in the United States
Abstract Background Previous estimates of the number of cancers attributable to physical inactivity in the United States have typically focused on only three malignancies (colon, endometrial, and postmenopausal breast cancer). Contemporary epidemiologic evidence suggests that physical inactivity could contribute to up to 15 types of cancer, and a dose–response effect has been demonstrated for 13… Continue reading Estimating cancer incidence attributable to physical inactivity in the United States
[ASAP] High Ectoine Production from Lignocellulosic Hydrolysate by Escherichia coli through Metabolic and Fermentation Engineering
GUK1 enzyme plays crucial role in lung cancer metabolism and growth
Lung cancer is a particularly challenging form of cancer. It often strikes unexpectedly and aggressively with little warning, and it can shapeshift in unpredictable ways to evade treatment. While researchers have gleaned important insights into the basic biology of lung cancer, some of the disease’s molecular maneuvers have remained elusive. Now, a team led by… Continue reading GUK1 enzyme plays crucial role in lung cancer metabolism and growth