Tag: Lung Cancer

Non-invasive multimodal CT deep learning biomarker to predict pathological complete response of non-small cell lung cancer following neoadjuvant immunochemotherapy: a multicenter study

AI SummaryThis study focuses on using pretreatment multimodal CT scans to create deep learning-based image biomarkers for predicting the pathological complete response of non-small cell lung cancer (NSCLC) following neoadjuvant immunochemotherapy. Deep learning features were extracted from both non-contrast enhanced and contrast enhanced CT scans to construct predictive models, with a fused model showing the… Continue reading Non-invasive multimodal CT deep learning biomarker to predict pathological complete response of non-small cell lung cancer following neoadjuvant immunochemotherapy: a multicenter study

Targeting IL-33 reprograms the tumor microenvironment and potentiates antitumor response to anti-PD-L1 immunotherapy

AI SummaryThis study focused on the use of IL-33 targeting to enhance the antitumor response to anti-PD-L1 immunotherapy by reprogramming the tumor microenvironment. The research demonstrated that blocking IL-33 using a fusion protein in combination with anti-PD-L1 treatment increased T cell responses, inhibited tumor progression, and provided long-term protective immunity. Targeting both IL-33 and PD-L1… Continue reading Targeting IL-33 reprograms the tumor microenvironment and potentiates antitumor response to anti-PD-L1 immunotherapy

[News] World’s first lung cancer vaccine trial launched in the UK

AI SummaryThis article discusses the launch of the world’s first lung cancer vaccine trial in the UK. A patient at University College London Hospitals NHS Foundation Trust was the first to receive the vaccine. This groundbreaking development has the potential to revolutionize treatment for lung cancer patients.A UK patient with lung cancer became the first… Continue reading [News] World’s first lung cancer vaccine trial launched in the UK

Editors’ Picks, August 2024: ‘Colon Age’ Screening Recs, Stress From Violence, and More 

AI SummaryThis article highlights the Editors’ Picks from August 2024 for the American Association for Cancer Research (AACR). The selections include topics such as a new metric called “Colon Age” for early-onset colorectal cancer screening, the relationship between exposure to neighborhood violence and glucocorticoid receptor signaling in lung tumors, and the development of a CD33-targeting… Continue reading Editors’ Picks, August 2024: ‘Colon Age’ Screening Recs, Stress From Violence, and More 

Next-generation EGFR tyrosine kinase inhibitors to overcome C797S mutation in non-small cell lung cancer (2019–2024)

AI SummaryThis article discusses the challenges posed by the C797S mutation in non-small cell lung cancer (NSCLC) and the limitations it creates for current EGFR tyrosine kinase inhibitors (EGFR-TKIs). The focus is on the need for fourth-generation EGFR-TKIs to target triple mutant EGFR with the C797S mutation. The review explores the discovery of novel inhibitors,… Continue reading Next-generation EGFR tyrosine kinase inhibitors to overcome C797S mutation in non-small cell lung cancer (2019–2024)

Artificial intelligence improves lung cancer diagnosis

AI SummaryThe article discusses the development of a digital pathology platform using artificial intelligence for diagnosing lung cancer. This platform utilizes new algorithms to automate the analysis of tissue sections from lung cancer patients, allowing for faster and more accurate detection of lung tumors. This advancement in technology is significant as it has the potential… Continue reading Artificial intelligence improves lung cancer diagnosis

Cornulacin: a new isoflavone from Cornulaca monacantha and its isolation, structure elucidation and cytotoxicity through EGFR-mediated apoptosis

AI SummaryThe research focuses on the discovery of a new isoflavone called cornulacin from the Cornulaca monacantha plant, along with the isolation and structure elucidation of this compound. The study also examines the cytotoxicity of cornulacin and other known compounds against pancreatic and ovarian cancer cell lines. The results show that cornulacin exhibited the most… Continue reading Cornulacin: a new isoflavone from Cornulaca monacantha and its isolation, structure elucidation and cytotoxicity through EGFR-mediated apoptosis