In lung cancer, overexpression of nuclear export proteins can result in inactivation of critical tumor suppressor proteins and cell-cycle regulators . Selinexor in combination with pembrolizumab demonstrated promising antitumor activity in patients with mNSCLC . The therapy-related toxic effects were consistent with the prior safety data for both drugs .
Tag: Lung Cancer
Safety, tolerability, and clinical activity of selinexor in combination with pembrolizumab in treatment of metastatic non–small cell lung cancer
In lung cancer, overexpression of nuclear export proteins can result in inactivation of critical tumor suppressor proteins and cell-cycle regulators . Selinexor in combination with pembrolizumab demonstrated promising antitumor activity in patients with mNSCLC . The therapy-related toxic effects were consistent with the prior safety data for both drugs .
Tecentriq Doubles 2-Year Survival Rate in Certain Patients With NSCLC
Tecentriq improved survival while maintaining quality-of-life in patients with non-small cell lung cancer considered ineligible for platinum
Chemoimmunotherapy in patients with extensive‐stage small cell lung cancer and a poor performance status
Abstract Background Immune checkpoint inhibitor combined with platinum-etoposide is the standard first-line therapy for patients with extensive-stage small cell lung cancer (ES-SCLC). The phase 3 clinical trials that led to the approval of chemoimmunotherapy in ES-SCLC excluded patients who had an Eastern Cooperative Group (ECOG) performance status (PS) of 2–3. Therefore, data on the efficacy… Continue reading Chemoimmunotherapy in patients with extensive‐stage small cell lung cancer and a poor performance status
Chemoimmunotherapy in patients with extensive‐stage small cell lung cancer and a poor performance status
Immune checkpoint inhibitor combined with platinum-etoposide is the standard first-line therapy for patients with extensive-stage small cell lung cancer . The phase 3 clinical trials that led to the approval of chemoimmunotherapy in ES-SCLC excluded patients who had an Eastern Cooperative Group (ECOG) performance status (PS) of 2–3 .
Depression, anxiety, and the risk of cancer: An individual participant data meta‐analysis
Abstract Background Depression and anxiety have long been hypothesized to be related to an increased cancer risk. Despite the great amount of research that has been conducted, findings are inconclusive. To provide a stronger basis for addressing the associations between depression, anxiety, and the incidence of various cancer types (overall, breast, lung, prostate, colorectal, alcohol-related,… Continue reading Depression, anxiety, and the risk of cancer: An individual participant data meta‐analysis
Depression, anxiety, and the risk of cancer: An individual participant data meta‐analysis
Depression and anxiety (symptoms and diagnoses) were associated with the incidence of lung cancer and smoking-related cancers . However, these associations were substantially attenuated when adjusting for known risk factors including smoking, alcohol use, and body mass index .
Single-cell sequencing on CD8+ TILs revealed the nature of exhausted T cells recognizing neoantigen and cancer/testis antigen in non-small cell lung cancer
Background CD8+tumor infiltrating lymphocytes (TILs) are often observed in non-small cell lung cancers (NSCLC). However, the characteristics of CD8+ TILs, especially T-cell populations specific for tumor antigens, remain poorly understood. Methods High throughput single-cell RNA sequencing and single-cell T-cell receptor (TCR) sequencing were performed on CD8+ TILs from three surgically-resected lung cancer specimens. Dimensional reduction… Continue reading Single-cell sequencing on CD8+ TILs revealed the nature of exhausted T cells recognizing neoantigen and cancer/testis antigen in non-small cell lung cancer
Phase 3 Trial Launches to Assess EGFR Inhibitor for NSCLC Subset
Researchers conducting this trial will compare zipalertinib plus chemotherapy with chemotherapy alone in patients with previously untreated, locally advanced or metastatic non-small cell lung cancer with the EGFR exon 20 insertion mutation.
Wildfire Smoke Causes Worse Overall Survival for Patients with NSCLC
Patients with non-small cell lung cancer who recently received surgery are more susceptible to wildfire smoke exposure, worsening their overall survival rate.