AI SummaryThis study examines smoking prevalence and its association with sociodemographic variables in cancer clinical trial participants. Nearly half of the 4326 patients enrolled in 29 trials reported ever smoking, with one in six reporting current or recent smoking. Factors associated with smoking included male gender, older age, Medicaid or no insurance, high socioeconomic deprivation,… Continue reading Smoking prevalence and association with sociodemographic variables in cancer clinical trial participants
Tag: Lung Cancer
Osimertinib after definitive chemoradiotherapy in unresectable stage III epidermal growth factor receptor-mutated non-small-cell lung cancer: analyses of central nervous system efficacy and distant progression from the phase III LAURA study☆
AI SummaryThis study focuses on the use of Osimertinib, a third-generation EGFR-tyrosine kinase inhibitor, after definitive chemoradiotherapy in unresectable stage III EGFR-mutated non-small-cell lung cancer. The research analyzes the drug’s efficacy in preventing distant progression, particularly in the central nervous system, in NSCLC patients. The LAURA study shows promising results in improving progression-free survival compared… Continue reading Osimertinib after definitive chemoradiotherapy in unresectable stage III epidermal growth factor receptor-mutated non-small-cell lung cancer: analyses of central nervous system efficacy and distant progression from the phase III LAURA study☆
How AI will transform cancer care
AI SummaryThe content discusses how artificial intelligence (AI) will transform cancer care by aiding in recommending the appropriate treatment for individual patients, as the therapeutic options in oncology have greatly expanded in recent years. This increase in complexity has made it challenging for oncologists to choose the right treatment for each patient. AI has the… Continue reading How AI will transform cancer care
Experimental mRNA cancer vaccine shows potential for advanced stage cancer patients in Phase 1 trial
AI SummaryIn a Phase 1 trial, an experimental mRNA cancer vaccine (mRNA-4359) has shown promise in patients with advanced solid cancers such as lung cancer and melanoma. Nineteen patients received between one and nine doses of the vaccine, which created an immune response against cancer. Adverse events were generally mild, including fatigue, injection site pain,… Continue reading Experimental mRNA cancer vaccine shows potential for advanced stage cancer patients in Phase 1 trial
BMI’s relation to cancer therapy mortality risks not so straightforward
Researchers examined the impact of obesity in relation to treatment and mortality from data on over 500,000 lung cancer patients. This study suggests that immunotherapy may not be the optimal treatment for obese patients.
New, rare type of small cell lung cancer identified
AI SummaryResearchers have identified a new and rare type of small cell lung cancer that predominantly affects younger individuals who have never smoked.A team of doctors and researchers have identified a new, rare type of small cell lung cancer that primarily affects younger people who have never smoked.
[ASAP] Discovery of Novel Non-nucleoside DOT1LR231Q Inhibitors with Improved Pharmacokinetic Properties and Anti-lung Cancer Efficacy
AI SummaryThe title suggests that researchers have discovered new inhibitors for DOT1L R231Q, a non-nucleoside enzyme involved in cancer. These inhibitors have improved pharmacokinetic properties, meaning they are more efficiently absorbed, distributed, metabolized, and excreted by the body. They also show anti-lung cancer efficacy, indicating they may be effective in treating lung cancer. The findings… Continue reading [ASAP] Discovery of Novel Non-nucleoside DOT1LR231Q Inhibitors with Improved Pharmacokinetic Properties and Anti-lung Cancer Efficacy
Novel study reveals how aging immune system fuels cancer growth, potentially opening new avenues for prevention
AI SummaryIn a novel study, researchers have discovered that an aging immune system accelerates tumor growth, shedding light on why aging is a significant risk factor for cancer. The findings suggest that the drug anakinra, commonly used for inflammatory conditions, could potentially be repurposed to prevent tumor growth by blocking harmful signals between early cancer… Continue reading Novel study reveals how aging immune system fuels cancer growth, potentially opening new avenues for prevention
scRNA+ TCR-seq revealed dual TCR T cells antitumor response in the TME of NSCLC
AI SummaryThis article discusses the utilization of single-cell RNA+TCR sequencing (scRNA+TCR seq) to explore the antitumor response of tumor-infiltrating T lymphocytes in the tumor microenvironment of non-small cell lung cancer patients. The study revealed the presence of dual TCR T cells with distinct characteristics, including clonal hyperplasia and tissue residency preferences. Dual TCR CD8+T cells… Continue reading scRNA+ TCR-seq revealed dual TCR T cells antitumor response in the TME of NSCLC
Non-invasive multimodal CT deep learning biomarker to predict pathological complete response of non-small cell lung cancer following neoadjuvant immunochemotherapy: a multicenter study
AI SummaryThis study focuses on using pretreatment multimodal CT scans to create deep learning-based image biomarkers for predicting the pathological complete response of non-small cell lung cancer (NSCLC) following neoadjuvant immunochemotherapy. Deep learning features were extracted from both non-contrast enhanced and contrast enhanced CT scans to construct predictive models, with a fused model showing the… Continue reading Non-invasive multimodal CT deep learning biomarker to predict pathological complete response of non-small cell lung cancer following neoadjuvant immunochemotherapy: a multicenter study