Scientists identify a new and surprising function of a membrane protein on the surface of cancer cells: It supports and stabilizes an important ‘co-stimulatory’ factor that enhances the activation of T cells, thus improving the immune response against the tumor.
Tag: Lipid and Membrane Biochemistry
Differential abundance of lipids and metabolites related to SARS-CoV-2 infection and susceptibility
Abstract The mechanisms driving SARS-CoV-2 susceptibility remain poorly understood, especially the factors determining why unvaccinated individuals remain uninfected despite high-risk exposures. To understand lipid and metabolite profiles related with COVID-19 susceptibility and disease progression. We collected samples from an exceptional group of unvaccinated healthcare workers heavily exposed to SARS-CoV-2 but not infected (‘non-susceptible’) and subjects… Continue reading Differential abundance of lipids and metabolites related to SARS-CoV-2 infection and susceptibility
[ASAP] Identifying Membrane Protein–Lipid Interactions with Lipidomic Lipid Exchange-Mass Spectrometry
[ASAP] Gradient Channel Segmentation in Covalent Organic Framework Membranes with Highly Oriented Nanochannels
Association Between Fluctuations in Blood Lipid Levels Over Time With Incident Alzheimer Disease and Alzheimer Disease-Related Dementias
AI SummaryLipid variability may contribute to the risk of Alzheimer’s disease. A study found that participants with higher variability in total cholesterol and triglyceride levels had an increased risk of developing Alzheimer’s disease. Further research is needed to understand the underlying mechanisms of this association.Background and Objectives Prevention strategies for Alzheimer disease and Alzheimer disease–related… Continue reading Association Between Fluctuations in Blood Lipid Levels Over Time With Incident Alzheimer Disease and Alzheimer Disease-Related Dementias
Multifaceted control of T cell differentiation by STIM1
[ASAP] An Unexpected Driving Force for Lipid Order Appears in Asymmetric Lipid Bilayers
[ASAP] Elucidation of the Role of Lipids in Late Endosomes on the Aggregation of Insulin
Editors’ Picks: Highlights from the AACR Journals
As you say farewell to summer, say hello to the latest installment of Editors’ Picks selected by the editors of the 10 AACR journals. This month’s selections include a drug that can help overcome resistance to several targeted therapies, an investigation of how tumor-derived extracellular vesicles inhibit CAR T-cell efficacy, a new type of bispecific… Continue reading Editors’ Picks: Highlights from the AACR Journals
Cholesterol Drug May Help Protect the Heart during Chemotherapy for Lymphoma
The cholesterol-lowering drug atorvastatin (Lipitor) may help reduce the risk of heart failure in people with lymphoma who receive chemotherapy drugs called anthracyclines, results from a clinical trial suggest. Anthracyclines, such as doxorubicin, are used to treat many types of cancer.