Scientists have developed a versatile platform with an electrically controlled nano-gate that can be used for applications in sensing, chemical synthesis, memristors, and neuromorphic computing. The nano-gate, which consists of a pore in a membrane, is closed by the formation of a precipitate and opened by the dissolution of the precipitate, which are regulated by… Continue reading Shut the nano gate! Electrical control of nanopore diameter
Tag: Lipid and Membrane Biochemistry
Targeting Tiam1 Enhances Hippocampal-Dependent Learning and Memory in the Adult Brain and Promotes NMDA Receptor-Mediated Synaptic Plasticity and Function
Excitatory synapses and the actin-rich dendritic spines on which they reside are indispensable for information processing and storage in the brain. In the adult hippocampus, excitatory synapses must balance plasticity and stability to support learning and memory. However, the mechanisms governing this balance remain poorly understood. Tiam1 is an actin cytoskeleton regulator prominently expressed in… Continue reading Targeting Tiam1 Enhances Hippocampal-Dependent Learning and Memory in the Adult Brain and Promotes NMDA Receptor-Mediated Synaptic Plasticity and Function
[ASAP] Amphiphilic Poly(ethylene glycol)-Cholesterol Conjugate: Stable Micellar Formulation for Efficient Loading and Effective Intracellular Delivery of Curcumin
ACS Applied Bio MaterialsDOI: 10.1021/acsabm.4c01657
The Japanese encephalitis virus NS1 protein concentrates ER membranes in a cytoskeleton-independent manner to facilitate viral replication
Class B scavenger receptor resists WSSV replication by recognizing the viral lipid molecule and promoting phagocytosis
PK 11195 derivatives: Exploring the influence of amide and heterocyclic substitution on A147T TSPO discrimination
The translocator protein (TSPO) is an 18 kDa protein on the outer mitochondrial membrane. It has gained significant interest in recent years for its potential as a therapeutic target and imaging biomarker, particularly in neuroinflammation, cancer, and central nervous system disorders (CNS). Clinical translation of ligands has been complicated by the presence of a common… Continue reading PK 11195 derivatives: Exploring the influence of amide and heterocyclic substitution on A147T TSPO discrimination
Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD
Cellular senescence, a hallmark of aging, has been implicated in Alzheimer’s disease (AD) pathogenesis. Cholesterol accumulation is known to drive cellular senescence; however, its underlying mechanisms are no…
Selenoproteins: The fountain of youth?
Researchers find that certain antioxidant enzymes, called selenoproteins, significantly contribute to fighting cell aging. The team used a gene knockout mouse model to help them study the effects of disrupting selenoprotein synthesis. This knockout negatively impacted hematopoietic stem cells and B cell-lineage immune cells, which was driven by the lack of selenoprotein-mediated fighting of lipid… Continue reading Selenoproteins: The fountain of youth?
[ASAP] Aerolysin Nanopore Structures Revealed at High Resolution in a Lipid Environment
[ASAP] Dual Targeting of Prostate-Specific Membrane Antigen and Fibroblast Activation Protein: Bridging Prostate Cancer Theranostics with Precision
ACS Applied Bio MaterialsDOI: 10.1021/acsabm.4c01914