Tag: Lipid and Membrane Biochemistry

CCR5-ligand decorated rilpivirine lipid-based nanoparticles for sustained antiretroviral responses

Abstract Antiretroviral therapy (ART) improves the quality of life for those living with the human immunodeficiency virus type one (HIV-1). However, poor compliance reduces ART effectiveness and leads to immune compromise, viral mutations, and disease co-morbidities. Here we develop a drug formulation in which a lipid-based nanoparticle (LBNP) carrying rilpivirine (RPV) is decorated with the… Continue reading CCR5-ligand decorated rilpivirine lipid-based nanoparticles for sustained antiretroviral responses

GP73 reinforces cytotoxic T-cell function by regulating HIF-1{alpha} and increasing antitumor efficacy

Background Immunotherapy that targets immune checkpoints has achieved revolutionary success, but its application in solid tumors remains limited, highlighting the need for reliable enhancement of the efficacy of immunotherapy. Golgi protein 73 (GP73), a Golgi membrane protein, has been implicated in various cellular processes, including immune regulation. Recent studies suggested that GP73 may play a… Continue reading GP73 reinforces cytotoxic T-cell function by regulating HIF-1{alpha} and increasing antitumor efficacy

Lipid metabolic remodeling delays senescence of T cells to potentiate their immunity against solid tumors

Background Tumor cells can drive the senescence of effector T cells by unbalancing their lipid metabolism, thereby limiting adoptive T cell therapy and contributing to tumor immune evasion. Our objective is to provide a feasible strategy for enhancing T cell treatment efficacy against solid tumors. Methods In this study, liposomal arachidonyl trifluoromethyl ketone (ATK) was… Continue reading Lipid metabolic remodeling delays senescence of T cells to potentiate their immunity against solid tumors

Prevalence and determinants of metabolic syndrome in 2338 childhood cancer survivors: A Dutch Childhood Cancer Survivor LATER 2 study

Abstract Background Because the occurrence of metabolic syndrome (MetS) might contribute to childhood cancer survivor’s excess risk of cardiovascular disease, the authors assessed the prevalence and determinants of MetS in the Dutch Childhood Cancer Survivor Study (DCCSS-LATER2) cohort. Methods In total, 2338 adult childhood cancer survivors (CCS) were cross-sectionally assessed for the prevalence of MetS,… Continue reading Prevalence and determinants of metabolic syndrome in 2338 childhood cancer survivors: A Dutch Childhood Cancer Survivor LATER 2 study

Synthesis and Evaluation of 6-Arylaminobenzamides as Positron Emission Tomography Imaging Ligands for the Sphingosine-1-Phosphate-5 Receptor

The sphingosine-1-phosphate-5 (S1P5) receptor is one of the five membrane G protein-coupled receptors that are activated by the lysophospholipid, sphingosine-1-phosphate, resulting in regulation of many cellular processes. S1P5 receptors are located on oligodendrocytes and are proposed to influence oligodendrocyte physiology. Understanding S1P5 modulation during processes such as remyelination could have potential applications for demyelinating CNS… Continue reading Synthesis and Evaluation of 6-Arylaminobenzamides as Positron Emission Tomography Imaging Ligands for the Sphingosine-1-Phosphate-5 Receptor