Scientists at the Icahn School of Medicine at Mount Sinai have developed a lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection, a challenge that has long been limited by the protective nature of the blood-brain barrier. The findings, in mouse models and isolated human brain tissue, were published… Continue reading Breakthrough technology enables mRNA delivery across the blood-brain barrier
Tag: Lipid and Membrane Biochemistry
[ASAP] Molecular Principles of Proton-Coupled Quinone Reduction in the Membrane-Bound Superoxide Oxidase
[ASAP] Emergence of Voronoi-Patterned Cellular Membranes via Confinement Transformation of Self-Assembled Metal–Organic Frameworks
[ASAP] Surface Lipids in Nematodes are Influenced by Development and Species-specific Adaptations
[ASAP] Nitroaromatic Compounds Dictate Electrochemical Properties of Escherichia coli by Manipulating the Cellular Membrane
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.4c01537
Fluctuating Cholesterol Tied to Dementia, Cognitive Decline
High levels of variability in cholesterol over time were linked to a significantly higher risk for dementia and cognitive decline in older adults, a new study found. Medscape Medical News
[ASAP] Development and Preclinical Assessment of a Palbociclib Nanostructured Lipid Carrier for Potential Breast Cancer Management
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.4c01122
PARPs and ADP-ribosylation-mediated biomolecular condensates: determinants, dynamics, and disease implications
The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly
Shut the nano gate! Electrical control of nanopore diameter
Scientists have developed a versatile platform with an electrically controlled nano-gate that can be used for applications in sensing, chemical synthesis, memristors, and neuromorphic computing. The nano-gate, which consists of a pore in a membrane, is closed by the formation of a precipitate and opened by the dissolution of the precipitate, which are regulated by… Continue reading Shut the nano gate! Electrical control of nanopore diameter