AI SummaryI cannot summarize the text as the given information is a DOI (Digital Object Identifier). It is typically used to identify and locate a specific article in a scholarly journal. Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.3c00547
Tag: Lipid and Membrane Biochemistry
Conserved structures of ESCRT-III superfamily members across domains of life
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Retinoid X receptor gamma dictates the activation threshold of group 2 innate lymphoid cells and limits type 2 inflammation in the small intestine
The molecular checkpoints in ILC2s that determine whether to launch a proinflammatory response are unknown. Zang et al. show that the dynamic regulation of RXRγ expression and its mediated lipid metabolic states function as a cell-intrinsic molecular checkpoint that confers the activation threshold of ILC2s in the small intestine.
Axon Initial Segment GABA Inhibits Action Potential Generation throughout Periadolescent Development
AI SummaryGABA at the axon initial segment inhibits action potential initiation in neurons, regardless of whether chloride flows out or into the cell.Neurons are remarkably polarized structures: dendrites spread and branch to receive synaptic inputs while a single axon extends and transmits action potentials (APs) to downstream targets. Neuronal polarity is maintained by the axon… Continue reading Axon Initial Segment GABA Inhibits Action Potential Generation throughout Periadolescent Development
A protein on cancer cells supports the immune response against tumors
Scientists identify a new and surprising function of a membrane protein on the surface of cancer cells: It supports and stabilizes an important ‘co-stimulatory’ factor that enhances the activation of T cells, thus improving the immune response against the tumor.
Differential abundance of lipids and metabolites related to SARS-CoV-2 infection and susceptibility
Abstract The mechanisms driving SARS-CoV-2 susceptibility remain poorly understood, especially the factors determining why unvaccinated individuals remain uninfected despite high-risk exposures. To understand lipid and metabolite profiles related with COVID-19 susceptibility and disease progression. We collected samples from an exceptional group of unvaccinated healthcare workers heavily exposed to SARS-CoV-2 but not infected (‘non-susceptible’) and subjects… Continue reading Differential abundance of lipids and metabolites related to SARS-CoV-2 infection and susceptibility
[ASAP] Identifying Membrane Protein–Lipid Interactions with Lipidomic Lipid Exchange-Mass Spectrometry
[ASAP] Gradient Channel Segmentation in Covalent Organic Framework Membranes with Highly Oriented Nanochannels
Association Between Fluctuations in Blood Lipid Levels Over Time With Incident Alzheimer Disease and Alzheimer Disease-Related Dementias
AI SummaryLipid variability may contribute to the risk of Alzheimer’s disease. A study found that participants with higher variability in total cholesterol and triglyceride levels had an increased risk of developing Alzheimer’s disease. Further research is needed to understand the underlying mechanisms of this association.Background and Objectives Prevention strategies for Alzheimer disease and Alzheimer disease–related… Continue reading Association Between Fluctuations in Blood Lipid Levels Over Time With Incident Alzheimer Disease and Alzheimer Disease-Related Dementias