BiomacromoleculesDOI: 10.1021/acs.biomac.4c01587
Tag: Lipid and Membrane Biochemistry
Regulation of Mutant Huntingtin Mitochondrial Toxicity by Phosphomimetic Mutations within Its N-Terminal Region
Huntington’s disease (HD), a neurodegenerative disease, affects approximately 30,000 people in the United States, with 200,000 more at risk. Mitochondrial dysfunction caused by mutant huntingtin (mHTT) drives early HD pathophysiology. mHTT binds the translocase of the mitochondrial inner membrane (TIM23) complex, inhibiting mitochondrial protein import and altering the mitochondrial proteome. The 17 aa HTT N-terminal sequence… Continue reading Regulation of Mutant Huntingtin Mitochondrial Toxicity by Phosphomimetic Mutations within Its N-Terminal Region
Immunostimulatory effects of Streptococcus sanguinis extracellular membrane vesicles protect oral gingival epithelial cells from periodontal pathobiont damage
Infection and Immunity, Ahead of Print.
Cryo-EM of native membranes reveals an intimate connection between the Krebs cycle and aerobic respiration in mycobacteria
Stressed microglia turn to the dark side in Alzheimer’s disease
A microglia subpopulation termed “dark microglia” has been associated with aging and neurodegeneration, although its role has remained elusive. New research from Flury et al. in this issue of Neuron shows that dark microglia drive neurodegeneration via secretion of toxic lipids.
Seeing more in expansion microscopy
In biology, seeing can lead to understanding, and researchers in Edward Boyden’s lab at MIT’s McGovern Institute are committed to bringing life into sharper focus. With a pair of new methods, they are expanding the capabilities of expansion microscopy—a high-resolution imaging technique the group introduced in 2015—so researchers everywhere can see more when they look… Continue reading Seeing more in expansion microscopy
[ASAP] Chemosensitizer Loaded NIR-Responsive Nanostructured Lipid Carriers: A Tool for Drug-Resistant Breast Cancer Synergistic Therapy
ACS Applied Bio MaterialsDOI: 10.1021/acsabm.4c01675
PCSK9 potentiates innate immune response to RNA viruses by preventing AIP4-mediated polyubiquitination and degradation of VISA/MAVS
[ASAP] Polyelectrolyte Membrane Enables Highly Reversible Zinc Battery Chemistry via Immobilizing Anion and Stabilizing Water
Breakthrough technology enables mRNA delivery across the blood-brain barrier
Scientists at the Icahn School of Medicine at Mount Sinai have developed a lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection, a challenge that has long been limited by the protective nature of the blood-brain barrier. The findings, in mouse models and isolated human brain tissue, were published… Continue reading Breakthrough technology enables mRNA delivery across the blood-brain barrier