Tag: Lipid and Membrane Biochemistry

Cancer cells may be using lipids to hide from the immune system

AI SummaryThe article highlights a new study revealing that certain cancer cells rely on specific lipids to evade the immune system, suggesting that targeting dietary lipids could be a potential treatment strategy. This research indicates that understanding how cancer cells utilize lipids may lead to novel therapeutic approaches in cancer treatment.New study demonstrates that one… Continue reading Cancer cells may be using lipids to hide from the immune system

A B cell receptor variant confers evolutionary protection against pathogens

AI SummaryThis article discusses the G396R coding variant in IGHG1, which confers evolutionary protection against pathogens. This variant has been observed in the Southeast Asian population and enhances immune resilience against various life-threatening organisms, highlighting the connection between human evolution and immune adaptation.The G396R coding variant in IGHG1, which encodes membrane-bound IgG1 heavy chain, might… Continue reading A B cell receptor variant confers evolutionary protection against pathogens

Review highlights mitochondrial dysfunction in cholestatic liver injury

AI SummaryThis article discusses the role of bile acids in cholestatic liver injury, focusing on how they can impact mitochondrial function, endoplasmic reticulum stress, inflammation, and autophagy. The review highlights how bile acids can induce cell death through two primary apoptotic pathways: death receptor-independent and death receptor-dependent pathways. In death receptor-independent pathways, bile acids impair… Continue reading Review highlights mitochondrial dysfunction in cholestatic liver injury

Rational design of NT-PSMA heterobivalent probes for prostate cancer theranostics

AI SummaryThe content discusses the rational design of heterobivalent probes targeting both the Prostate-Specific Membrane Antigen (PSMA) and the neurotensin receptor-1 (NTS1) for prostate cancer theranostics. The development of a hybrid probe, JMV 7489, was reported, showing good affinity towards PSMA and lower affinity towards NTS1. The study highlights the importance of the DOTA macrocycle… Continue reading Rational design of NT-PSMA heterobivalent probes for prostate cancer theranostics

Populations Are Different; So Is Their Lp(a)!

AI SummaryThe article discusses the research conducted by Professor Zhenyue Chen on lipids that increase ASCVD risk, specifically focusing on the differences in Lp(a) levels among various populations.Medscape spoke with Professor Zhenyue Chen of Shanghai Jiao Tong University of Medicine in China about her research into the lipids that increase ASCVD risk. theheart.org on Medscape

Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway

AI SummaryThe article evaluates the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for managing non-alcoholic steatohepatitis (NASH) by modulating the cGAS-STING pathway. In silico data analysis identified three key genes and their epigenetic modulators, with subsequent experiments demonstrating that Zbiotics administration in NASH-induced rats improved liver function, lipid profiles, and reduced inflammation and steatosis.… Continue reading Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway

Tubular scaffolds boost stem cell-driven bone regeneration in skull defects

AI SummaryThis article discusses the development of tubular scaffolds made from electrospun membranes that enhance bone regeneration in critical skull defects. These scaffolds, designed to mimic natural bone structures, provide an ideal environment for adipose-derived stem cells (rADSCs) to thrive and accelerate healing. By incorporating advanced materials such as polycaprolactone, PLGA, and nano-hydroxyapatite, researchers achieved… Continue reading Tubular scaffolds boost stem cell-driven bone regeneration in skull defects