Tag: Laboratory Biochemistry
Using mass spectrometry to characterize commercial Alternaria alternata allergen extract content
Got Milk? ELISA Analysis Of Casein Proteins In Methylprednisolone
[ASAP] In-Cell Mass Spectrometry and Ultraviolet Photodissociation Navigates the Intracellular Protein Heterogeneity
Editors’ Picks, January 2025: Evolutionary Insights Into Cancer, Impact of Nicotine Levels in E-cigarettes, and More
As winter marches on, let’s dive into the cool articles highlighted this month by the editors of the AACR journals. Grab a blanket and keep reading to learn how nicotine levels in e-cigarettes impact exposure to various toxins, why certain species are more likely to develop cancer, and results from a first-in-human trial evaluating a… Continue reading Editors’ Picks, January 2025: Evolutionary Insights Into Cancer, Impact of Nicotine Levels in E-cigarettes, and More
[ASAP] On-line Inductively Coupled Plasma Mass Spectrometry Reveals Material Degradation Dynamics of Au and Cu Catalysts during Electrochemical CO2 Reduction
PEPPI-MS protocols reveal chemical structure of cellular proteins on a large scale
Researchers have detailed PEPPI-MS, an experimental protocol combining high-resolution protein fractionation using SDS-polyacrylamide gel electrophoresis (SDS-PAGE) with the latest mass spectrometry technology to enable highly sensitive analysis of proteoforms, the diverse chemical structures of proteins. This protocol paper is expected to contribute to the development of disease diagnostics based on proteoform information.
Novel B7-H3 CAR T cells show potent antitumor effects in glioblastoma: a preclinical study
Background B7 homolog 3 (B7-H3), an overexpressed antigen across multiple solid cancers, represents a promising target for CAR T cell therapy. This study investigated the expression of B7-H3 across various solid tumors and developed novel monoclonal antibodies (mAbs) targeting B7-H3 for CAR T cell therapy. Methods Expression of B7-H3 across various solid tumors was evaluated… Continue reading Novel B7-H3 CAR T cells show potent antitumor effects in glioblastoma: a preclinical study
Molecular mechanism of ligand recognition and activation of lysophosphatidic acid receptor LPAR6
B7-H3 CAR-T cell therapy combined with irradiation is effective in targeting bulk and radiation-resistant chordoma cancer cells
Background Chordoma is a slow-growing, primary malignant bone tumor that arises from notochordal tissue in the midline of the axial skeleton. Surgical excision with negative margins is the mainstay of treatment, but high local recurrence rates are reported even with negative margins. High-dose radiation therapy (RT), such as with proton or carbon ions, has been… Continue reading B7-H3 CAR-T cell therapy combined with irradiation is effective in targeting bulk and radiation-resistant chordoma cancer cells