Tag: Laboratory Biochemistry
Tracking proteasome degradation: A cross-organ analysis via intact degradomics mass spectrometry
[ASAP] Discovery of Diphenyl Ether Derivatives as Novel BKCa Channel Activators: Structure-Activity Relationship, Cryo-EM Complex Structures, and In Vivo Animal Studies
Protein ligation for the assembly and study of nonribosomal peptide synthetase megaenzymes
Nonribosomal peptide synthetases (NRPSs) are biosynthetic enzymes found in bacteria and fungi, that synthesize a plethora of pharmaceutically relevant compounds. NRPSs consist of repeating sets of functional domains called modules, and each module is responsible for the incorporation of a single amino acid to the growing peptidyl intermediate. The synthetic logic of an NRPS resembles… Continue reading Protein ligation for the assembly and study of nonribosomal peptide synthetase megaenzymes
[ASAP] Multi-dimensional, Multi-scale Analysis of Interphase Chemistry for Enhanced Fast-Charging of Lithium-Ion Batteries with Ion Mass Spectrometry
[ASAP] Column Chromatography-Free Synthesis of Spirooxindole and Spiroindanone-Based Naphthalimides as Potent c-MYC G4 Stabilizers and HSA Binders for Elevating Anticancer Potential
ACS Applied Bio MaterialsDOI: 10.1021/acsabm.4c01726
[ASAP] Micellar Solvent Accessibility of Esterified Polyoxyethylene Chains as Crucial Element of Polysorbate Oxidation: A Density Functional Theory, Molecular Dynamics Simulation and Liquid Chromatography/Mass Spectrometry Investigation
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.4c01015
[ASAP] Quantitative Analysis of Neuropeptide Y (NPY) and C-Terminal Glycine-Extended NPY by Mass Spectrometry and Their Localization in the Developing and Sexual Adult Mouse Brains
Cryo-EM structure of Sudan ebolavirus glycoprotein complexed with its human endosomal receptor NPC1
Abstract Sudan ebolavirus (SUDV), like Ebola ebolavirus (EBOV), poses a significant threat to global health and security due to its high lethality. However, unlike EBOV, there are no approved vaccines or treatments for SUDV, and its structural interaction with the endosomal receptor NPC1 remains unclear. This study compares the glycoproteins of SUDV and EBOV (in… Continue reading Cryo-EM structure of Sudan ebolavirus glycoprotein complexed with its human endosomal receptor NPC1