AI SummaryMIT neuroscientists have discovered a peptide that can reverse neurodegeneration and other symptoms of Alzheimer’s disease by interfering with an enzyme called CDK5 that is overactive in Alzheimer’s patients. In mice, the peptide led to reductions in neurodegeneration, DNA damage, and improvements in cognitive abilities, leading researchers to believe it could serve as a… Continue reading A new peptide may hold potential as an Alzheimer’s treatment
Tag: Innate Immunity
Eosinophils promote effector functions of lung group 2 innate lymphoid cells in allergic airway inflammation in mice
Type 2 inflammation reduces SARS-CoV-2 replication in the airway epithelium in allergic asthma through functional alteration of ciliated epithelial cells
Airway hyperresponsiveness reflects corticosteroid-sensitive mast cell involvement across asthma phenotypes
A20 is a master switch of IL-33 signaling in macrophages and determines IL-33–induced lung immunity
CCL5 is a potential bridge between type 1 and type 2 inflammation in asthma
Lung dopaminergic nerves facilitate the establishment of TH2 resident memory cells in early life
Complex regulation of alarmins S100A8/A9 and secretion via gasdermin D pores exacerbates autoinflammation in familial Mediterranean fever
Lung-resident CD69+ST2+ TH2 cells mediate long-term type 2 memory to inhaled antigen in mice
New technologies reveal cross-cutting breakdowns in Alzheimer’s disease
After decades of fundamental scientific and drug discovery research, Alzheimer’s disease has remained inscrutable and incurable, with a bare minimum of therapeutic progress. But in a new review article in Nature Neuroscience, MIT scientists write that by employing the new research capability of single-cell profiling, the field has rapidly achieved long-sought insights with strong potential for both… Continue reading New technologies reveal cross-cutting breakdowns in Alzheimer’s disease