Tag: Innate Immunity

Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway

AI SummaryThe article evaluates the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for managing non-alcoholic steatohepatitis (NASH) by modulating the cGAS-STING pathway. In silico data analysis identified three key genes and their epigenetic modulators, with subsequent experiments demonstrating that Zbiotics administration in NASH-induced rats improved liver function, lipid profiles, and reduced inflammation and steatosis.… Continue reading Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway

Circumventing resistance within the Ewing sarcoma microenvironment by combinatorial innate immunotherapy

AI SummaryThis article discusses the use of combinatorial innate immunotherapy to overcome resistance within the Ewing sarcoma microenvironment. The study shows that a chimeric antigen receptor (CAR) NK cell targeting MCAM, combined with NKTR-255 (IL-15 agonist) and Magrolimab (CD47 blockade), significantly enhances NK cell cytotoxicity and macrophage phagocytic activity against ES cells. Results from in… Continue reading Circumventing resistance within the Ewing sarcoma microenvironment by combinatorial innate immunotherapy

Trained innate immunity: concept, nomenclature and future perspectives

AI SummaryThis article discusses the concept of trained innate immunity, which refers to the enhanced responsiveness of innate immune cells following exposure to certain stimuli. The nomenclature of this phenomenon is explored, as well as its potential future perspectives in the field of immunology. The article likely delves into the mechanisms behind trained innate immunity,… Continue reading Trained innate immunity: concept, nomenclature and future perspectives

Amyloid-{beta} Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling

AI SummaryThis research investigates how amyloid-β affects NMDA receptors and dendritic spine loss, potentially impairing learning and memory in Alzheimer’s disease. The study shows that amyloid-β engages AKAP-CaN signaling through mGluR1 activation, leading to changes in NMDA receptor function and dendritic spine stability. This highlights a new way in which amyloid-β disrupts synaptic function.Neuronal excitatory… Continue reading Amyloid-{beta} Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling

Endosialin-positive CAFs promote hepatocellular carcinoma progression by suppressing CD8+ T cell infiltration

AI SummaryThis research focuses on the role of endosialin-positive cancer-associated fibroblasts (CAFs) in promoting hepatocellular carcinoma (HCC) progression by suppressing CD8+ T cell infiltration. The study found that endosialin knockout led to inhibited tumor growth and increased CD8+ T cell infiltration in mouse models and cell cultures. Endosialin was shown to inhibit the expression and… Continue reading Endosialin-positive CAFs promote hepatocellular carcinoma progression by suppressing CD8+ T cell infiltration