Tag: Innate Immunity
Towards more efficient synthetic immunomodulators: biological characterization and mechanism of action of monosaccharide-derived TLR4 agonists
Toll-like receptors (TLRs), including TLR4, play a crucial role in innate immunity activation, and small molecular TLR4 activators (agonists) are in preclinical and clinical phase of development as vaccine adjuvant or tumor immunotherapeuutics. .Recently, we have generated novel glucosamine-derived compounds, FP molecules, that are active as TLR4 agonists. Despite their chemical structure different from LPS,… Continue reading Towards more efficient synthetic immunomodulators: biological characterization and mechanism of action of monosaccharide-derived TLR4 agonists
Small RNA and Toll-like receptor interactions: origins and disease mechanisms
[ASAP] Discovery of Novel Isoxazole-Based Small-Molecule Toll-Like Receptor 8 Antagonists
Autoimmunity in Long-COVID
[ASAP] Dual-Locked Fluorescence Probe for Monitoring the Dynamic Transition of Pulmonary Macrophages
[ASAP] SPECT Imaging of Cardiac Inflammation by Targeting IL4 Receptor-α on Macrophages
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.4c01336
Oral vancomycin induces PSC-IBD remission, driving gut microbiome and metabolic shifts
A four-week treatment with oral vancomycin led to clinical remission in PSC-IBD patients, accompanied by significant shifts in gut microbiota, reduced inflammation, and altered bile acid and short-chain fatty acid metabolism—effects that reversed upon treatment withdrawal. Study: Open label vancomycin in primary sclerosing cholangitis-inflammatory bowel disease: improved colonic disease activity and associations with changes in host-microbiome-metabolomic… Continue reading Oral vancomycin induces PSC-IBD remission, driving gut microbiome and metabolic shifts
Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance
CD56bright cytokine-induced memory-like NK cells and NK-cell engagers synergize against non-small cell lung cancer cancer-stem cells
Background Due to their enhanced responsiveness and persistence, cytokine-induced memory-like (CIML)-natural killer (NK) cells have emerged as new immunotherapeutic tools against malignancies. However, their effects on tumor-cell spread and metastases in solid tumors remain poorly investigated. Moreover, a clear identification of the most effective CIML-NK subsets, especially in controlling cancer stem cells (CSC), is still… Continue reading CD56bright cytokine-induced memory-like NK cells and NK-cell engagers synergize against non-small cell lung cancer cancer-stem cells