Tag: Innate Immunity
Airway hyperresponsiveness reflects corticosteroid-sensitive mast cell involvement across asthma phenotypes
A20 is a master switch of IL-33 signaling in macrophages and determines IL-33–induced lung immunity
CCL5 is a potential bridge between type 1 and type 2 inflammation in asthma
Lung dopaminergic nerves facilitate the establishment of TH2 resident memory cells in early life
Complex regulation of alarmins S100A8/A9 and secretion via gasdermin D pores exacerbates autoinflammation in familial Mediterranean fever
Lung-resident CD69+ST2+ TH2 cells mediate long-term type 2 memory to inhaled antigen in mice
New technologies reveal cross-cutting breakdowns in Alzheimer’s disease
After decades of fundamental scientific and drug discovery research, Alzheimer’s disease has remained inscrutable and incurable, with a bare minimum of therapeutic progress. But in a new review article in Nature Neuroscience, MIT scientists write that by employing the new research capability of single-cell profiling, the field has rapidly achieved long-sought insights with strong potential for both… Continue reading New technologies reveal cross-cutting breakdowns in Alzheimer’s disease
Professor Emeritus Richard Wurtman, influential figure in translational research, dies at 86
AI SummaryRichard Wurtman, a prominent neurochemist and neuropharmacologist who was a member of the MIT faculty for 44 years, has died at the age of 86. Wurtman’s research on neurotransmitters and the impact of nutrition on brain function has made significant contributions to our understanding of conditions such as Alzheimer’s disease and premenstrual syndrome. He… Continue reading Professor Emeritus Richard Wurtman, influential figure in translational research, dies at 86
Silent synapses are abundant in the adult brain
AI SummaryMIT neuroscientists have discovered that the adult brain contains silent synapses, immature connections between neurons that remain inactive until they are recruited to help form new memories. About 30% of synapses in the adult mouse brain are silent, and the researchers believe this helps the brain continuously form new memories without modifying existing synapses.… Continue reading Silent synapses are abundant in the adult brain