Tag: Innate Immunity
Cancer‐associated fibroblasts contribute to the immunosuppressive landscape and influence the efficacy of the combination therapy of PD‐1 inhibitors and antiangiogenic agents in hepatocellular carcinoma
Cancer-associated fibroblasts (CAFs) play a key role in HCC TME remodeling . The level of abundance of CAFs may significantly affect the prognosis and outcome in patients . Patients in the CAF high cluster had a higher levels of inflammatory cell infiltration and a more significant immunosuppressive microenvironment .
Cancer‐associated fibroblasts contribute to the immunosuppressive landscape and influence the efficacy of the combination therapy of PD‐1 inhibitors and antiangiogenic agents in hepatocellular carcinoma
Cancer-associated fibroblasts (CAFs) play a key role in HCC TME remodeling . The level of abundance of CAFs may significantly affect the prognosis and outcome in patients . Patients in the CAF high cluster had a higher levels of inflammatory cell infiltration and a more significant immunosuppressive microenvironment .
Atlas of human brain blood vessels highlights changes in Alzheimer’s disease
AI SummaryScientists from MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL), The Picower Institute for Learning and Memory, and The Broad Institute of MIT and Harvard have created a molecular atlas of human brain vasculature and its changes in Alzheimer’s disease (AD) across six brain regions. The researchers characterized over 22,514 vascular cells from different… Continue reading Atlas of human brain blood vessels highlights changes in Alzheimer’s disease
The translation potential of harnessing the resolution of inflammation
IL-4 receptor alpha blockade dampens allergic inflammation and upregulates IL-17A expression to promote S aureus clearance in antigen sensitized mouse skin
Rapid reduction in Staphylococcus aureus in atopic dermatitis subjects following dupilumab treatment
Blood transcriptomic signature in type-2 biomarker-low severe asthma and asthma control
Efficacy and safety of pralsetinib in patients with advanced RET fusion‐positive non–small cell lung cancer
Pralsetinib showed robust and durable clinical activity with a well-tolerated safety profile in Chinese patients with RET fusion-positive non–small cell lung cancer (NSCLC) The most common grade 3/4 treatment-related adverse events in 68 patients were anemia (35.3%) and decreased neutrophil count (33.8%) As of March 4, 2022 (data cutoff), a confirmed objective response was observed… Continue reading Efficacy and safety of pralsetinib in patients with advanced RET fusion‐positive non–small cell lung cancer