Tag: Innate Immunity
[Comment] Expanding the spectrum of type 1 IFN neuroinflammation
Type 1 interferons (IFNs) have a crucial role in the innate immune system’s protection against viral infections. The production of type 1 IFNs is triggered by a signalling pathway that is activated when innate sensors recognise viral nucleic acids. Type 1 IFNs bind to the receptors IFNAR1 and IFNAR2, thereby initiating JAK-STAT signalling, which promotes… Continue reading [Comment] Expanding the spectrum of type 1 IFN neuroinflammation
Correction for Manik et al., Structural basis for TIR domain–mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM
New insights into the endotypes of chronic rhinosinusitis in the biologic era
[ASAP] Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Restricts Inflammatory Progression through Limiting Macrophage Infiltration in DRG and Sciatic Nerve during Diabetic Peripheral Neuropathy
Researchers develop mouse model to study neutrophilic asthma
A better understanding of inflammation and lung immunity over the past two decades has led to new, innovative treatments for asthma, including biologic therapies. This is especially true for a subtype known as eosinophilic asthma-asthma that’s related to the recruitment and overactivation of white blood cells in the lungs called eosinophils. However, a different type… Continue reading Researchers develop mouse model to study neutrophilic asthma
Exploring the link between parvovirus B19 and encephalitis: a systematic review and comprehensive meta-analysis of molecular and serological evidence
Encephalitis, a severe brain inflammation, can arise due to various infectious agents, including viruses like Parvovirus B19 (B19V). Previously linked to mild neonatal and young one’s illnesses and some haemat… Continue reading on BioMed Central
Plasmacytoid dendritic cells alleviate allergic asthma via airway epithelial cells-dependent thymosin β4 expression
From rare to more common: The emerging role of omics in improving understanding and treatment of severe inflammatory and hyperinflammatory conditions.
Towards more efficient synthetic immunomodulators: biological characterization and mechanism of action of monosaccharide-derived TLR4 agonists
Toll-like receptors (TLRs), including TLR4, play a crucial role in innate immunity activation, and small molecular TLR4 activators (agonists) are in preclinical and clinical phase of development as vaccine adjuvant or tumor immunotherapeuutics. .Recently, we have generated novel glucosamine-derived compounds, FP molecules, that are active as TLR4 agonists. Despite their chemical structure different from LPS,… Continue reading Towards more efficient synthetic immunomodulators: biological characterization and mechanism of action of monosaccharide-derived TLR4 agonists