Tag: Innate Immunity
Finding some stability in adaptable brains
AI SummaryThe content discusses the balance in the brain between stability and flexibility, focusing on individual neurons and synapses in the sensory cortex. Pyramidal neurons have both stable and flexible synapses, with some synapses losing their flexibility by adulthood. The study reveals that stable synapses in a specific region of these neurons have unique properties… Continue reading Finding some stability in adaptable brains
Contradiction: Inhibiting inflammation and immunosuppression in the treatment of IBD
Dorsal root ganglion inflammation by oxaliplatin toxicity: DPEP1 as possible target for peripheral neuropathy prevention
Peripheral neuropathy (PN) constitutes a dose-limiting side effect of oxaliplatin chemotherapy that often compromises the efficacy of antineoplastic treatments. Sensory neurons damage in dorsal root ganglia (D…
Salmonella Typhimurium infection inhibits macrophage IFNβ signaling in a TLR4-dependent manner
Infection and Immunity, Ahead of Print.
A cGAS-mediated type I interferon response in human CD4+ T cells depends on productive infection and is conserved over HIV types and strains
Systemic T-cell activation and interferon-γ activity in indeterminate severe hepatitis (iSH) are reminiscent of hemophagocytic lymphohistiocytosis (HLH): Implications for T-cell and interferon-γ directed therapies.
AI SummaryThis article discusses how systemic T-cell activation and interferon-γ activity in indeterminate severe hepatitis (iSH) are similar to hemophagocytic lymphohistiocytosis (HLH). The implications of this include the potential for T-cell and interferon-γ directed therapies for treating iSH. This research highlights the importance of understanding the immune response in severe liver diseases and how it… Continue reading Systemic T-cell activation and interferon-γ activity in indeterminate severe hepatitis (iSH) are reminiscent of hemophagocytic lymphohistiocytosis (HLH): Implications for T-cell and interferon-γ directed therapies.
Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway
AI SummaryThe article evaluates the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for managing non-alcoholic steatohepatitis (NASH) by modulating the cGAS-STING pathway. In silico data analysis identified three key genes and their epigenetic modulators, with subsequent experiments demonstrating that Zbiotics administration in NASH-induced rats improved liver function, lipid profiles, and reduced inflammation and steatosis.… Continue reading Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway
Circumventing resistance within the Ewing sarcoma microenvironment by combinatorial innate immunotherapy
AI SummaryThis article discusses the use of combinatorial innate immunotherapy to overcome resistance within the Ewing sarcoma microenvironment. The study shows that a chimeric antigen receptor (CAR) NK cell targeting MCAM, combined with NKTR-255 (IL-15 agonist) and Magrolimab (CD47 blockade), significantly enhances NK cell cytotoxicity and macrophage phagocytic activity against ES cells. Results from in… Continue reading Circumventing resistance within the Ewing sarcoma microenvironment by combinatorial innate immunotherapy