Science Immunology, Volume 10, Issue 103, January 2025.
Tag: Innate Immunity
Prior influenza virus infection alleviates an arbovirus encephalitis by reducing viral titer, inflammation, and cellular infiltrates in the central nervous system
Direct lysine dimethylation of IRF3 by the methyltransferase SMYD3 attenuates antiviral innate immunity
Immune 87: When the immune system misbehaves
Immune discusses basophils as regulators of of lung inflammation over space and time, and neoself-antigens as the primary target for autoreactive T cells in human lupus. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Click arrow to playDownload Immune 87 (100 MB .mp3, 69 min)Subscribe (free): Apple Podcasts, RSS, emailBecome a patron of Immune! Links for this episode MicrobeTV Discord… Continue reading Immune 87: When the immune system misbehaves
Development of small-molecule fluorescent probes targeting neutrophils via N-formyl peptide receptors
N-formyl peptide receptors (FPRs) are membrane receptors that are abundantly expressed in innate immune cells, including neutrophils and platelets, demonstrating potential new targets for immune system regulation and the treatment of inflammatory conditions. We report here the development and bio-physical validation of new FPR imaging agents as effective tools to track FPR distribution, localisation and… Continue reading Development of small-molecule fluorescent probes targeting neutrophils via N-formyl peptide receptors
Sensing of SARS-CoV-2-infected cells by plasmacytoid dendritic cells is modulated via an interplay between CD54/ICAM-1 and CD11a/LFA-1 αL integrin
Expression of Concern for Herrera et al., “Protection against Malaria in Aotus Monkeys Immunized with a Recombinant Blood-Stage Antigen Fused to a Universal T-Cell Epitope: Correlation of Serum Gamma Interferon Levels with Protection”
Infection and Immunity, Ahead of Print.
Neutrophil adhesion to vessel walls impairs pulmonary circulation in COVID-19 pathology
Abstract Microthrombus formation is associated with COVID-19 severity; however, the detailed mechanism remains unclear. In this study, we investigated mouse models with severe pneumonia caused by SARS-CoV-2 infection by using our in vivo two-photon imaging system. In the lungs of SARS-CoV-2-infected mice, increased expression of adhesion molecules in intravascular neutrophils prolonged adhesion time to the… Continue reading Neutrophil adhesion to vessel walls impairs pulmonary circulation in COVID-19 pathology
FAP-targeted radioligand therapy with 68Ga/177Lu-DOTA-2P(FAPI)2 enhance immunogenicity and synergize with PD-L1 inhibitors for improved antitumor efficacy
Background Fibroblast activation protein (FAP)-targeted radioligand therapy, with immunomodulatory effects, has shown efficacy in both preclinical and clinical studies. We recently reported on a novel dimeric FAP-targeting radiopharmaceutical, 68Ga/177Lu-DOTA-2P(FAPI)2, which demonstrated increased tumor uptake and prolonged retention in various cancers. However, further exploration is required to understand the therapeutic efficacy and underlying mechanisms of combining… Continue reading FAP-targeted radioligand therapy with 68Ga/177Lu-DOTA-2P(FAPI)2 enhance immunogenicity and synergize with PD-L1 inhibitors for improved antitumor efficacy
Antibodies against the multifaceted cathepsin D protein open new avenues for TNBC immunotherapy
Triple-negative breast cancer (TNBC) is a heterogeneous breast cancer subtype characterized by aggressive clinical behavior and poor prognosis. The immune landscape associated with TNBC often reveals high immunogenicity. Therefore, immunotherapy, which has demonstrated its efficacy in different cancer types, could be a promising strategy for TNBC, given the limited therapeutic options currently available besides conventional… Continue reading Antibodies against the multifaceted cathepsin D protein open new avenues for TNBC immunotherapy