In his weekly clinical update, Dr. Griffin discusses modeling poliovirus transmission and responses in New York State, FDA approves first vaccine for pregnant individuals to prevent RSV in infants, prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices, Nirmatrelvir resistance – de novo E166V/L50V mutations in an immunocompromised… Continue reading TWiV 1038: Clinical update with Dr. Daniel Griffin
Tag: Influenza
Antibody-mediated NK cell activation as a correlate of immunity against influenza infection
Abstract Antibodies play a critical role in protection against influenza; yet titers and viral neutralization represent incomplete correlates of immunity. Instead, the ability of antibodies to leverage the antiviral power of the innate immune system has been implicated in protection from and clearance of influenza infection. Here, post-hoc analysis of the humoral immune response to… Continue reading Antibody-mediated NK cell activation as a correlate of immunity against influenza infection
The emergence of influenza B as a major respiratory pathogen in the absence of COVID-19 during the 2021–2022 flu season in China
The emergence of COVID-19 and the implementation of preventive measures and behavioral changes have led to a significant decrease in the prevalence of other respiratory viruses . However, the manner in which se… Continue reading on BioMed Central
[ASAP] Zinc Carnosine Metal–Organic Coordination Polymer as a Potent Broadly Active Influenza Vaccine Platform with In Vitro Shelf-Stability
Molecular Pharmaceutics is a formative form of drug therapy . The study was published in the journal Human Pharmacology & Human Immunology
Immunological profile of mice immunized with a polyvalent virosome-based influenza vaccine
Viruses Three IAVs isolated from swine were selected for the preparation of the influenza vaccine: A/swine/Brazil/025 − 15/2015 1 A.3.3.2 (H1N1pdm; NCBI GenBank Accession HA = MH559931 and NA = MH559933; BRMSA 1710), A/swine/Brazil/223-15-1/2015 1B.2.4 (H1N2; NCBI GenBank Accession HA = MH560035 and NA = MH560037; BRMSA 1698) and A/swine/Brazil/028-15-8/2015 (H3N2; NCBI GenBank Accession HA = MH559963 and NA = MH559965; BRMSA 1697). H1N1 and H1N2 viral samples were propagated… Continue reading Immunological profile of mice immunized with a polyvalent virosome-based influenza vaccine
Immune cells present in people months before influenza infection, finds study
St. Jude Children’s Research Hospital scientists, in collaboration with the Institute of Environmental Science and Research (ESR) Limited, found that immune cells present in people months before influenza (flu) infection could more accurately predict if an individual would develop symptoms than current methods which primarily rely on antibody levels. The study found certain immune cells… Continue reading Immune cells present in people months before influenza infection, finds study
Influenza a virus regulates interferon signaling and its associated genes; MxA and STAT3 by cellular miR-141 to ensure viral replication
Cell lines Human lung carcinoma epithelial cells A549 cell lines obtained from (VACSERA, Giza, Egypt) and MDCK (Madin-Darby canine kidney) cell lines were propagated in the Roswell Park Memorial Institute 1640 media (RPMI), containing 25 mM HEPS, 4 mM L-glutamine, and 10% of heat-inactivated bovine serum albumin (BSA) and incubated at 37 °C and relative humidity… Continue reading Influenza a virus regulates interferon signaling and its associated genes; MxA and STAT3 by cellular miR-141 to ensure viral replication
Immune cells present long before infection predict flu symptoms
Scientists found that immune cells present in individuals long before influenza infection predict whether the illness is symptomatic.
Baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology
Abstract Evidence suggests that innate and adaptive cellular responses mediate resistance to the influenza virus and confer protection after vaccination. However, few studies have resolved the contribution of cellular responses within the context of preexisting antibody titers. Here, we measured the peripheral immune profiles of 206 vaccinated or unvaccinated adults to determine how baseline variations… Continue reading Baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology
A polyvalent virosomal influenza vaccine induces broad cellular and humoral immunity in pigs
Anderson TK, Chang J, Arendsee ZW, Venkatesh D, Souza CK, Kimble JB, et al. Swine influenza A viruses and the tangled relationship with humans. Cold Spring Harb Perspect Med. 2021;11:a038737. Article PubMed PubMed Central Google Scholar Nelson MI, Schaefer R, Gava D, Cantão ME, Ciacci-Zanella JR. Influenza A viruses of human origin in swine. Brazil… Continue reading A polyvalent virosomal influenza vaccine induces broad cellular and humoral immunity in pigs