AI SummaryDuring a bout of influenza, B cells take different paths to defend the body. Some become antibody producing cells, while others become lung-resident memory B cells (lung-BRMs) that provide long-term immunity in the lungs. Understanding the mechanism of lung-BRM development is important for improving flu vaccines. A study has shown that interferon-gamma produced by… Continue reading Interferon-gamma essential for lung-resident memory B cell development after influenza infection
Tag: Influenza
Flu: Interferon-gamma from T follicular helper cells is required to create lung-resident memory B cells
AI SummaryDuring influenza, B cells interact with other immune cells and differentiate into lung-resident memory B cells (lung-BRMs) that provide pulmonary immunity. These lung-BRMs migrate to the lungs and serve as the first line of defense, producing antibodies in future infections.During a bout of influenza, B cells interact with other immune cells and then take… Continue reading Flu: Interferon-gamma from T follicular helper cells is required to create lung-resident memory B cells
Researcher helps boost immune system memory against influenza
Researchers are one step closer to making the T cell army stronger. In a recent study, researchers found that by manipulating one molecular signaling pathway in the T cells that participate in clearing influenza virus in the lungs, the strength and longevity of immunological memory produced can be improved.
Interferon-γ production by Tfh cells is required for CXCR3+ pre-memory B cell differentiation and subsequent lung-resident memory B cell responses
Lung-resident memory B cells (lung-BRMs) provide superior protection against respiratory viruses. Arroyo-Díaz et al. examine the requirements for lung-BRM development and reveal that IFN-γ production by Tfh cells is essential for the differentiation of memory B cell precursors that give rise to lung-BRMs and subsequent protection against heterosubtypic influenza infection.
TWiV 1042: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses China’s health authorities fighting surge in cases of Mpox unknown origin, analysis of seasonal variation of antibiotic prescribing for respiratory tract diagnoses in primary care practices, prevalence and associated outcomes of co-infection between SARS-CoV-2 and influenza, comparison of bivalent and monovalent mRNA vaccine boosters, optimal duration of… Continue reading TWiV 1042: Clinical update with Dr. Daniel Griffin
Highly pathogenic avian influenza A (H5N1) in marine mammals and seabirds in Peru
Abstract Highly pathogenic avian influenza (HPAI) A/H5N1 viruses (lineage 2.3.4.4b) are rapidly invading the Americas, threatening wildlife, poultry, and potentially evolving into the next global pandemic. In November 2022 HPAI arrived in Peru, triggering massive pelican and sea lion die-offs. We report genomic characterization of HPAI/H5N1 in five species of marine mammals and seabirds (dolphins,… Continue reading Highly pathogenic avian influenza A (H5N1) in marine mammals and seabirds in Peru
New insights into how lung cells detect influenza virus
Researchers from Trinity College Dublin have discovered some new and surprising ways that viral RNA and influenza virus are detected by human lung cells, which has potential implications for treating people affected by such viruses. Influenza viruses remain a major threat to human health and can cause severe symptoms in young, elderly, and immuno-compromised populations,… Continue reading New insights into how lung cells detect influenza virus
[Newsdesk] Risk of highly pathogenic avian influenza to humans
Reports from several countries of highly pathogenic avian influenza A(H5N1) in mammalian species have raised concerns of the virus’ risk to humans. Talha Burki reports.
Scientists unpick how lung cells induce immune response to influenza
Researchers have discovered some new and surprising ways that viral RNA and influenza virus are detected by human lung cells, which has potential implications for treating people affected by such viruses.
Advocating a watch-and-prepare approach with avian influenza
The global outbreak of H5N1 highly pathogenic avian influenza virus and its high toll on animal populations raise concerns about spillover into humans, but human host barriers need to be considered when estimating transmission potential. Over the past two years, highly pathogenic avian influenza viruses (HPAIVs) of the H5 subtype have increasingly spread through animal… Continue reading Advocating a watch-and-prepare approach with avian influenza