Deciphering the therapeutic effects of Xiyanping injection: insights into pulmonary and gut microbiome modulation, SerpinB2/PAI-2 targeting, and alleviation of influenza a virus-induced lung injury

Infection with Influenza A virus (IAV) induces severe inflammatory responses and lung injury, contributing significantly to mortality and morbidity rates. Alterations in the microbial composition of the lungs … Continue reading on BioMed Central

TWiV 1186: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin and co-host Vincent Racaniello lament about the public changes from withdrawing from the WHO to health and scientific communication pauses by the Trump Administration after a brief discussion of Marburg in Tanzania and mpox in England before reviewing cats and bird flu, the recent statistics on RSV, influenza… Continue reading TWiV 1186: Clinical update with Dr. Daniel Griffin

Raman signatures of type A and B influenza viruses: molecular origin of the “catch and kill” inactivation mechanism mediated by micrometric silicon nitride powder

* Corresponding authors a Biomedical Engineering Center, Kansai Medical University, 1-9-11 Shin-machi, Hirakata, Osaka 573-1191, Japan E-mail: pezzotti@hirakata.kmu.ac.jp b Department of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, 465 Kajii-cho, Kyoto 602-8566, Japan E-mail: mazda@koto.kpu-m.ac.jp c Department of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, 160-0023 Tokyo, Japan d… Continue reading Raman signatures of type A and B influenza viruses: molecular origin of the “catch and kill” inactivation mechanism mediated by micrometric silicon nitride powder

TWiV 1184: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses current and past outbreaks of “vaccine” preventable diseases including whooping cough, polio and measles with your co-host Vincent Racaniello and the recent increase in norovirus outbreaks, if alcohol-based hand sanitizers aid in the spread of norovirus before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections,… Continue reading TWiV 1184: Clinical update with Dr. Daniel Griffin

Unexpected viral reservoir: influenza A thrives in cattle mammary glands

Scientists reveal the mammary gland’s hidden role in influenza A infections, spotlighting the urgent need for targeted vaccines to protect cattle, milk safety, and public health. Review: Influenza A virus in dairy cattle: infection biology and potential mammary gland-targeted vaccines. Image Credit: Aleksandar Malivuk / Shutterstock In a recent review published in the journal NPJ Vaccines, researchers… Continue reading Unexpected viral reservoir: influenza A thrives in cattle mammary glands

GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding

Abstract The Eurasian avian-like (EA) H1N1 swine influenza virus (SIV) possesses the capacity to instigate the next influenza pandemic, owing to its heightened affinity for the human-type α-2,6 sialic acid (SA) receptor. Nevertheless, the molecular mechanisms underlying the switch in receptor binding preferences of EA H1N1 SIV remain elusive. In this study, we conduct a… Continue reading GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding