Tag: Influenza

Influenza virus antibodies inhibit antigen-specific de novo B cell responses in mice

AI SummaryThis article discusses how pre-existing antibodies against the influenza virus can inhibit the immune system’s ability to generate new B cell responses specific to the virus in mice. This suggests that prior exposure to the virus may affect the effectiveness of future immune responses against it. The findings have implications for vaccine development and… Continue reading Influenza virus antibodies inhibit antigen-specific de novo B cell responses in mice

TWiV 1142: Clinical update with Dr. Daniel Griffin

AI SummaryIn this clinical update, Dr. Daniel Griffin discusses global transmission of mpox, different virus clades, associated pathogenesis, vaccination, antiviral therapy, and the US response to controlling an African outbreak. He also covers recent statistics on SARS-CoV-2 infections, vaccine authorizations, economic benefits of annual COVID vaccines, breakthrough infections, convalescent plasma use, managing healthcare worker infections,… Continue reading TWiV 1142: Clinical update with Dr. Daniel Griffin

Universal flu vaccine candidate protects against infection in mice

AI SummaryThe title indicates that a universal flu vaccine candidate has been developed that includes proteins from 8 strains of influenza. This approach is likely to provide broader protection against various flu viruses compared to traditional vaccines targeting a single strain. The study likely involved testing the vaccine in mice and found that it was… Continue reading Universal flu vaccine candidate protects against infection in mice

Intranasal administration of octavalent next-generation influenza vaccine elicits protective immune responses against seasonal and pre-pandemic viruses

AI SummaryThis article discusses a study where an octavalent next-generation influenza vaccine was administered intranasally and found to elicit protective immune responses against both seasonal and pre-pandemic influenza viruses. The results suggest that this new vaccine approach could provide broader protection against influenza viruses, including those with pandemic potential.

Nasal symbiont Staphylococcus epidermidis restricts influenza A virus replication via the creation of a polyamine-deficient cellular environment

AI SummaryThe article discusses how the nasal symbiont Staphylococcus epidermidis helps to restrict influenza A virus replication by creating a polyamine-deficient cellular environment in the nasal epithelium. The study found that polyamines are necessary for the life cycle of the influenza A virus and that S. epidermidis inoculation suppressed virus infection by reducing polyamine concentrations… Continue reading Nasal symbiont Staphylococcus epidermidis restricts influenza A virus replication via the creation of a polyamine-deficient cellular environment

[Newsdesk] Research in brief

AI SummaryThis brief research article discusses the potential of targeting internal viral proteins for a universal influenza vaccine. The researchers in the USA tested this approach by immunizing monkeys with a vaccine expressing specific antigens. The study suggests that harnessing T-cell immunity against internal viral proteins could be a promising pathway for developing universal influenza… Continue reading [Newsdesk] Research in brief

T helper cells may be the key to improving annual influenza vaccines

AI SummarySummary: The article discusses the role of T follicular helper cells in influencing the effectiveness of annual influenza vaccines. Scientists have found that these immune cells may contribute to suboptimal immune responses by recognizing incorrect parts of the virus. Understanding this mechanism could lead to improvements in vaccine efficacy.Scientists have discovered why the flu… Continue reading T helper cells may be the key to improving annual influenza vaccines