Tag: Influenza

TWiV 1182: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses how vaccination and vaccine hesitancy affects public health and disease spread in terms of mpox, the first human death from H5N1 in US, why one should not feed their pets raw pet food and the metapneumonia outbreak in China before reviewing the recent statistics on RSV, influenza… Continue reading TWiV 1182: Clinical update with Dr. Daniel Griffin

New molecule shows promise in protecting mice from influenza

Researchers at the University of Gothenburg, Sweden, in collaboration with colleagues in China, have discovered an antibody-like molecule that can protect mice from various influenza viruses. The findings could pave the way for new treatments and the development of broader influenza vaccines. We have identified a small molecule that binds to the virus’s surface protein… Continue reading New molecule shows promise in protecting mice from influenza

Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection

Abstract Influenza remains a persistent global health challenge, largely due to the virus’ continuous antigenic drift and occasional shift, which impede the development of a universal vaccine. To address this, the identification of broadly neutralizing antibodies and their epitopes is crucial. Nanobodies, with their unique characteristics and binding capacity, offer a promising avenue to identify such… Continue reading Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection

β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus

Abstract Disease tolerance is an evolutionarily conserved host defense strategy that preserves tissue integrity and physiology without affecting pathogen load. Unlike host resistance, the mechanisms underlying disease tolerance remain poorly understood. In the present study, we investigated whether an adjuvant (β-glucan) can reprogram innate immunity to provide protection against influenza A virus (IAV) infection. β-Glucan… Continue reading β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus

Development of broadly protective influenza B vaccines

Abstract Influenza B viruses pose a significant threat to global public health, leading to severe respiratory infections in humans and, in some cases, death. During the last 50 years, influenza B viruses of two antigenically distinct lineages (termed ‘Victoria’ and ‘Yamagata’) have circulated in humans, necessitating two different influenza B vaccine strains. In this study,… Continue reading Development of broadly protective influenza B vaccines

Author Correction: Morbidity of SARS-CoV-2 in the evolution to endemicity and in comparison with influenza

Correction to: Communications Medicine (2024) 4:244; https://doi.org/10.1038/s43856-024-00633-5; Article published online 22 November 2024 The published document was missing the information that the authors obtained permission to use the WWSCAN wastewater data, as described in data.wastewaterscan.org. The publication should have included the following attribution: “These data were collected as part of the WastewaterSCAN / SCAN project,… Continue reading Author Correction: Morbidity of SARS-CoV-2 in the evolution to endemicity and in comparison with influenza

TWiV 1181: Seek and ye shall find, coronaviruses and phage

TWiV discusses an outbreak of influenza H5N1 that killed over half of the great cats at a Washington sanctuary, origin and cross-species transmission of bat coronaviruses in China, and the diverse and abundant phages that enter cells via receptors encoded on conjugative plasmids. Hosts: Vincent Racaniello, Rich Condit, and Jolene Ramsey Click arrow to playDownload TWiV… Continue reading TWiV 1181: Seek and ye shall find, coronaviruses and phage

TWiV 1180: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the recent increase in norovirus outbreaks, human cases of H5N1 avian influenza, before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, how effective Molnupiravir is and provides information for Columbia University Irving Medical Center’s long COVID treatment center.… Continue reading TWiV 1180: Clinical update with Dr. Daniel Griffin

Predicting H5N1 disease severity based on T cell responses

New research led by scientists at La Jolla Institute for Immunology (LJI) suggests that many people already have immune cells on “stand by” to fight the H5N1 virus, also known as highly pathogenic avian influenza. The H5N1 “bird flu” virus emerged in 2022 and has spread widely in animal populations, including poultry and cattle. According… Continue reading Predicting H5N1 disease severity based on T cell responses