Tag: Influenza

The CXCL8/MAPK/hnRNP-K axis enables susceptibility to infection by EV-D68, rhinovirus, and influenza virus in vitro

Abstract Respiratory viruses pose an ongoing threat to human health with excessive cytokine secretion contributing to severe illness and mortality. However, the relationship between cytokine secretion and viral infection remains poorly understood. Here we elucidate the role of CXCL8 as an early response gene to EV-D68 infection. Silencing CXCL8 or its receptors, CXCR1/2, impedes EV-D68… Continue reading The CXCL8/MAPK/hnRNP-K axis enables susceptibility to infection by EV-D68, rhinovirus, and influenza virus in vitro

TWiV 1192: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss confirmation of Robert F Kennedy as HHS sectary, mpox, Ebola, how the American people support vaccine development and administration, the measles outbreak in the US-Texas, Georgia and influenza: the number of human infections, high avian flu in mammals, house cats and dairy cows before… Continue reading TWiV 1192: Clinical update with Dr. Daniel Griffin

Influenza A viruses adapt shape in response to environmental pressures

Influenza A virus particles strategically adapt their shape — to become either spheres or larger filaments — to favor their ability to infect cells depending on environmental conditions, according to a new study. This previously unrecognized response could help explain how influenza A and other viruses persist in populations, evade immune responses, and acquire adaptive… Continue reading Influenza A viruses adapt shape in response to environmental pressures

Influenza A virus rapidly adapts particle shape to environmental pressures

Abstract Enveloped viruses such as influenza A virus (IAV) often produce a mixture of virion shapes, ranging from 100 nm spheres to micron-long filaments. Spherical virions use fewer resources, while filamentous virions resist cell-entry pressures such as antibodies. While shape changes are believed to require genetic adaptation, the mechanisms of how viral mutations alter shape remain… Continue reading Influenza A virus rapidly adapts particle shape to environmental pressures

TWiV 1190: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss changes in access to public health information and aid mechanisms such as the return of MMWR, the largest tuberculosis outbreak in the US ever, lack of USAID in fighting Marburg and Ebola outbreaks in Africa, discussing if avian influenza virus is airborne, how eggs… Continue reading TWiV 1190: Clinical update with Dr. Daniel Griffin

Evaluation of humoral immune response and milk antibody transfer in calves and lactating cows vaccinated with inactivated H5 avian influenza vaccine

Abstract The detection of Highly Pathogenic Avian Influenza (HPAI) A(H5N1) in dairy cattle in the United States has raised concerns about human exposure. This study evaluated the efficacy of various doses of an inactivated H5 AI vaccine in cattle and assessed antibody transfer in milk against a recent bovine isolate of HPAI A(H5N1, clade 2.3.4.4b).… Continue reading Evaluation of humoral immune response and milk antibody transfer in calves and lactating cows vaccinated with inactivated H5 avian influenza vaccine

Author Correction: β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus

Correction to: Nature Immunology https://doi.org/10.1038/s41590-024-02041-2, published online 8 January 2025. In the version of the article initially published, there were duplicate graphs in Fig. 5a, where the bottom-right Ifnar1–/– panel was a duplicate of the top-left control. The corrected Fig. 5 is now available in the HTML and PDF versions of the article. Author informationAuthor… Continue reading Author Correction: β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus