In his weekly clinical update, Dr. Griffin discusses current and past outbreaks of “vaccine” preventable diseases including whooping cough, polio and measles with your co-host Vincent Racaniello and the recent increase in norovirus outbreaks, if alcohol-based hand sanitizers aid in the spread of norovirus before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections,… Continue reading TWiV 1184: Clinical update with Dr. Daniel Griffin
Tag: Influenza
Prior influenza virus infection alleviates an arbovirus encephalitis by reducing viral titer, inflammation, and cellular infiltrates in the central nervous system
Unexpected viral reservoir: influenza A thrives in cattle mammary glands
Scientists reveal the mammary gland’s hidden role in influenza A infections, spotlighting the urgent need for targeted vaccines to protect cattle, milk safety, and public health. Review: Influenza A virus in dairy cattle: infection biology and potential mammary gland-targeted vaccines. Image Credit: Aleksandar Malivuk / Shutterstock In a recent review published in the journal NPJ Vaccines, researchers… Continue reading Unexpected viral reservoir: influenza A thrives in cattle mammary glands
[ASAP] Ultrasensitive Specific Detection of Anti-influenza A H1N1 Hemagglutinin Monoclonal Antibody Using Silicon Nanowire Field Effect Biosensors
ACS Applied Bio MaterialsDOI: 10.1021/acsabm.4c01263
GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding
Abstract The Eurasian avian-like (EA) H1N1 swine influenza virus (SIV) possesses the capacity to instigate the next influenza pandemic, owing to its heightened affinity for the human-type α-2,6 sialic acid (SA) receptor. Nevertheless, the molecular mechanisms underlying the switch in receptor binding preferences of EA H1N1 SIV remain elusive. In this study, we conduct a… Continue reading GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding
Proteolysis-targeting influenza vaccine strains induce broad-spectrum immunity and in vivo protection
Abstract Generating effective live vaccines from intact viruses remains challenging owing to considerations of safety and immunogenicity. Approaches that can be applied in a systematic manner are needed. Here we created a library of live attenuated influenza vaccines by using diverse cellular E3 ubiquitin ligases to generate proteolysis-targeting (PROTAR) influenza A viruses. PROTAR viruses were… Continue reading Proteolysis-targeting influenza vaccine strains induce broad-spectrum immunity and in vivo protection
PROTAR Vaccine 2.0 generates influenza vaccines by degrading multiple viral proteins
Abstract Manipulating viral protein stability using the cellular ubiquitin-proteasome system (UPS) represents a promising approach for developing live-attenuated vaccines. The first-generation proteolysis-targeting (PROTAR) vaccine had limitations, as it incorporates proteasome-targeting degrons (PTDs) at only the terminal ends of viral proteins, potentially restricting its broad application. Here we developed the next-generation PROTAR vaccine approach, referred to… Continue reading PROTAR Vaccine 2.0 generates influenza vaccines by degrading multiple viral proteins
G-quadruplex-forming small RNA inhibits coronavirus and influenza A virus replication
Abstract Future pandemic threats may be caused by novel coronaviruses and influenza A viruses. Here we show that when directly added to a cell culture, 12mer guanine RNA (G12) and its phosphorothioate-linked derivatives (G12(S)), rapidly entered cytoplasm and suppressed the propagation of human coronaviruses and influenza A viruses to between 1/100 and nearly 1/1000 of normal… Continue reading G-quadruplex-forming small RNA inhibits coronavirus and influenza A virus replication
The threat of avian influenza H5N1 looms over global biodiversity
The highly pathogenic avian influenza H5N1 is an emerging and unexpected threat to many wild animal species, which has implications for ecological processes, ecosystem services and conservation of threatened species. International collaboration and information-sharing is essential for surveillance, early diagnosis and the provision of financial and technical instruments to enable worldwide actions. Download PDF As… Continue reading The threat of avian influenza H5N1 looms over global biodiversity
TWiV 1183: More than 2024 viruses
TWiV reviews some of their favorite virology stories from 2024. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Click arrow to playDownload TWiV 1183 (66 MB .mp3, 111 min) Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 SARS-CoV-2 origins (TWiV Special) TWiV 1163: Hepadnaviridae in the… Continue reading TWiV 1183: More than 2024 viruses