Tag: Immunodeficiency Disorders
Withania somnifera extracts induced attenuation of HIV-1: a mechanistic approach to restrict viral infection
In vitro cytotoxicity of Withania somnifera extracts on TZM-bl cell line and PBMCs WSAQ and WSHA extracts were initially examined for their cellular viability on TZM-bl cell lines and PBMCs using MTT quantitative colorimetric assay. Increasing the concentrations directly attributed to the increase in the cytotoxicity for WSHA and WSAQ extracts in the TZM-bl cells… Continue reading Withania somnifera extracts induced attenuation of HIV-1: a mechanistic approach to restrict viral infection
Learning how to control HIV from African genomes
A study on almost four thousand people of African descent has identified a gene that acts as natural defense against HIV by limiting its replication in certain white blood cells . This research paves the way for new treatment strategies and underscores the importance of studying diverse ancestral populations to better address their specific medical… Continue reading Learning how to control HIV from African genomes
Efficacy of Pitavastatin Treatment for people with HIV on Antiretroviral Therapy
Pitavastatin is a pharmaceutical agent studied for its potential in treating People Living with HIV, or PLHIV, who also have dyslipidemia and are receiving ritonavir-boosted atazanavir (ATV/r) as part of their antiretroviral therapy (ART). Dyslipidemia is the imbalance of lipids such as cholesterol, triglycerides, low-density lipoprotein cholesterol (“good” cholesterol – LDL) and high-density lipoprotein (“bad” cholesterol – HDL) It is normally treated… Continue reading Efficacy of Pitavastatin Treatment for people with HIV on Antiretroviral Therapy
Heavy-chain CDR3-engineered B cells facilitate in vivo evaluation of HIV-1 vaccine candidates
V2-glycan/apex broadly neutralizing antibodies (bnAbs) recognize a closed quaternary structure of the HIV-1 envelope glycoprotein. He, Ou et al. introduced HCDR3 regions of neutralizing antibodies targeting this epitope into a diverse repertoire of murine B cell receptors (BCRs). Upon vaccination, these edited B cells affinity matured and generated potent neutralizing sera, highlighting the potential of an HCDR3-focused vaccine approach.
[Viewpoint] Global HIV control: is the glass half empty or half full?
The massive scale-up of HIV treatment and prevention over the past two decades has resulted in important reductions in new infections and mortality globally . Reduction in HIV incidence has been unequal, however, with worsening epidemics in regions where the reach and scale of . HIV control programmes have been insufficient, especially in eastern Europe,… Continue reading [Viewpoint] Global HIV control: is the glass half empty or half full?