Fernandez-de Céspedes MV, Hoffman HK, Carter H, Simons LM, Naing L, Ablan SD, Scheiblin DA, Hultquist JF, van Engelenburg SB, Freed EO. 2022. Rab11-FIP1C is dispensable for HIV-1 replication in primary CD4(+) T cells, but its role is cell type dependent in immortalized human T-cell lines. J Virol 96:e0087622.
Tag: Immunodeficiency Disorders
Interim Analysis: Open-Label Extension Study of Leniolisib for Patients with APDS
Post-Transplant Late Complications Increase Over Time for Patients with SCID: A Primary Immune Deficiency Treatment Consortium (PIDTC) Landmark Study
Estimating the contribution of CD4 T cell subset proliferation and differentiation to HIV persistence
Abstract Persistence of HIV in people living with HIV (PWH) on suppressive antiretroviral therapy (ART) has been linked to physiological mechanisms of CD4+ T cells. Here, in the same 37 male PWH on ART we measure longitudinal kinetics of HIV DNA and cell turnover rates in five CD4 cell subsets: naïve (TN), stem-cell- (TSCM), central- (TCM), transitional-… Continue reading Estimating the contribution of CD4 T cell subset proliferation and differentiation to HIV persistence
[Editorial] Putting people first in communication about HIV
As a journal publishing content on HIV, we use language to disseminate ideas, information, and innovations. Throughout our different sections we cover a broad range of content in diverse styles: from discursive pieces in the Culture section, to the rigorous presentation of academic research in our Articles. As editors, we are acutely aware of the… Continue reading [Editorial] Putting people first in communication about HIV
Alternate Hemibody Hyperkinetic and Hypokinetic Movement Disorders Due to Strategic Lesions in Cerebral Toxoplasmosis
This case report describes a women with a background of HIV presenting with complex involuntary movements with markedly different phenomenology on the right and left side of her body.
Soluble CD4 and low molecular weight CD4-mimetic compounds sensitize cells to be killed by anti-HIV cytotoxic immunoconjugates
Elliott JH, Wightman F, Solomon A, Ghneim K, Ahlers J, Cameron MJ, Smith MZ, Spelman T, McMahon J, Velayudham P, Brown G, Roney J, Watson J, Prince MH, Hoy JF, Chomont N, Fromentin R, Procopio FA, Zeidan J, Palmer S, Odevall L, Johnstone RW, Martin BP, Sinclair E, Deeks SG, Hazuda DJ, Cameron PU, Sékaly… Continue reading Soluble CD4 and low molecular weight CD4-mimetic compounds sensitize cells to be killed by anti-HIV cytotoxic immunoconjugates
Relative resistance of patient-derived envelope sequences to SERINC5-mediated restriction of HIV-1 infectivity
Mann JK, Byakwaga H, Kuang XT, Le AQ, Brumme CJ, Mwimanzi P, Omarjee S, Martin E, Lee GQ, Baraki B, Danroth R, McCloskey R, Muzoora C, Bangsberg DR, Hunt PW, Goulder PJR, Walker BD, Harrigan PR, Martin JN, Ndung’u T, Brockman MA, Brumme ZL. 2013. Ability of HIV-1 Nef to downregulate CD4 and HLA class… Continue reading Relative resistance of patient-derived envelope sequences to SERINC5-mediated restriction of HIV-1 infectivity
Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population
AI SummaryThere is currently no cure for HIV, and it remains a major issue in low-income countries. Viral load and various factors contribute to HIV progression and transmission. Genetic factors and viral adaptation play a role in viral load variability. Studies have shown viral escape mutations from HLA class I alleles.INTRODUCTIONNo cure for HIV has… Continue reading Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population
Ototoxicity associated with high‐dose carboplatin for patients with previously treated germ cell tumors
AI SummaryHigh-dose carboplatin is used in curative high-dose chemotherapy for patients with germ cell tumors. However, it can cause hearing loss. This study found that most patients developed moderate to profound hearing loss in speech frequencies after treatment, and approximately one in five needed hearing aids. Strategies to reduce this side effect are necessary and… Continue reading Ototoxicity associated with high‐dose carboplatin for patients with previously treated germ cell tumors