HIV-1 latently infected cells are indistinguishable from uninfected cells, creating a barrier for cure. Using DOGMA-seq, Wei et al. identified single-cell epigenetic, transcriptional, and surface protein states of latent and transcriptionally active HIV-1-infected cells. The heterogeneous HIV-1-infected cells are driven by interferon responses, cytotoxic T cell differentiation, AP-1-driven TNF responses, and cell death. IKZF3 promotes the proliferation of HIV-1-infected cells.
Tag: Immunodeficiency Disorders
Pinpointing HIV immune response
New research combining computer modeling and experiments with macaques shows the body’s immune system helps control human immunodeficiency virus (HIV) infections largely by suppressing viral production in already infected cells while also killing viral infected cells, but only within a narrow time window at the start of a cell’s infection.
1147-F Human endogenous retrovirus-K proteins form VLPs with dense envelope incorporation – explaining HERV-K immunogenicity in patients and yielding a tool for breaking tolerance to HERV envelope proteins
Background Human endogenous retroviruses and, in particular the betaretrovirus HERV-K, are upregulated at the protein level in a wide range of cancers. Spontaneous immunity to HERV-K has been observed in autoimmune diseases and cancers. Recently, Ng et al., studying non-small-cell lung cancer (NSCLC) linked the presence of HERV-K transcripts and HERV-K immunity to the formation… Continue reading 1147-F Human endogenous retrovirus-K proteins form VLPs with dense envelope incorporation – explaining HERV-K immunogenicity in patients and yielding a tool for breaking tolerance to HERV envelope proteins
442-E A novel targeted, type I interferon producing, innate lymphocyte therapy with potent anti-tumor activity
Background Plasmacytoid Dendritic Cells (pDCs) – sometimes referred to as type I interferon producing innate lymphocyte cells – are known as a master regulator of the immune system. The pDCs are responsible for the body’s Interferon (IFN) α production, and contain multiple direct effector functions that can mount strong anti-tumor responses. The low number of… Continue reading 442-E A novel targeted, type I interferon producing, innate lymphocyte therapy with potent anti-tumor activity
[Feature] Successes and challenges in Thailand’s HIV response
AI SummaryThailand has been a leader in HIV/AIDS care in Asia due to its community engagement, but there are challenges ahead.Long at the forefront of innovations in HIV/AIDS care in Asia, Thailand’s community engagement has been key in their HIV response. But, Sima Barmania reports, all is not plain sailing.
[Editorial] Transplant donation without discrimination
AI SummaryAdvancements in HIV treatment have improved the lives of those with HIV, but longer lifespans come with new challenges related to age-related comorbidities. Organ transplantation can be a lifesaving option for those with end-stage organ diseases, regardless of their HIV status.After four decades of global research on HIV, advances in treatment have not only… Continue reading [Editorial] Transplant donation without discrimination
P43-9 The treatment of Kaposi sarcoma: Chasing the progressive disease with the presentation of KICS
Kaposi Sarcoma is rare cancer associated with the coinfection of KSHV and HIV. However, the KSHV Inflammatory Cytokine Syndrome is even rarer diagnosed among Kaposi Sarcoma patients and has poor survival outcomes despite the treatment.
MO21-5 Chemotherapy regimen of Kaposi sarcoma in HIV/AIDS patients: A systematic review of randomized controlled trials
Kaposi sarcoma (KS) is one of common HIV-associated cancer. The availability of antiretroviral therapy (ART), liposomal doxorubicin, and several chemotherapy drugs have been reported the efficacy and tolerable side effect in case series and retrospective study. However, little is known the best chemotherapy regimen in this population. Thus, this systematic review intends to evaluate the… Continue reading MO21-5 Chemotherapy regimen of Kaposi sarcoma in HIV/AIDS patients: A systematic review of randomized controlled trials
HIV-1 Tat commandeers nuclear export of Rev-viral RNA complex by controlling hnRNPA2-mediated splicing
HIV-1 diverts cortical actin for particle assembly and release
Abstract Enveloped viruses assemble and bud from the host cell membranes. Any role of cortical actin in these processes have often been a source of debate. Here, we assessed if cortical actin was involved in HIV-1 assembly in infected CD4 T lymphocytes. Our results show that preventing actin branching not only increases HIV-1 particle release but… Continue reading HIV-1 diverts cortical actin for particle assembly and release