Background CD4+ T-cell lymphocytopenia and immune dysfunction are factors that drive the onset and persistence of Kaposi sarcoma (KS) in people with (PWH) and without HIV. Standard chemotherapy agents for KS can contribute to increasing CD4+ T cell lymphocytopenia. IL-7 is a cytokine that is essential in T-cell development, proliferation and homeostasis. In PWH, IL-7… Continue reading Phase I study of efineptakin alfa (NT-I7) for the treatment of Kaposi sarcoma
Tag: Immunodeficiency Disorders
Deficiency of adenosine deaminase 2 skews adaptive immune repertoires towards specific sets of T and B cell receptors
Conformational activation and disulfide exchange in HIV-1 Env induce cell-free lytic/fusogenic transformation and enhance infection
Longitudinal changes in the transcriptionally active and intact HIV reservoir after starting ART during acute infection
The synthesis and investigation of novel 3-benzoylbenzofurans and pyrazole derivatives for anti-HIV activity.
The emergence of drug-resistant viruses continues to be an obstacle to effectively controlling the HIV/AIDS pandemic. The development of novel drugs with high potency and the ability to fully eradicate HIV-1 infections is therefore of critical importance. Novel pyrazole derivatives were synthesized from 3-benzoylbenzofurans and characterized by mass spectrometry (MS) and nuclear magnetic resonance (NMR)… Continue reading The synthesis and investigation of novel 3-benzoylbenzofurans and pyrazole derivatives for anti-HIV activity.
Targeting Ikaros and Aiolos with pomalidomide fails to reactivate or induce apoptosis of the latent HIV reservoir
Clinical, immunologic and genetic characteristics of 148 patients with NK cell deficiency
TWiV 1188: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss changes in access to public health information, the Marburg and Ebola outbreaks in Africa, the largest tuberculosis outbreak in the US ever, the politicization of polio vaccine campaigns in Pakistan, effect of high pathogenic influenza in animals and on the economy before Dr. Griffin… Continue reading TWiV 1188: Clinical update with Dr. Daniel Griffin
[Feature] Artificial intelligence powers HIV testing services in Kenya
Data gathered over the past two decades of the HIV response are now informing efforts to use artificial intelligence to assess HIV risk and improve care in Kenya. Roger Pebody reports.
[Editorial] Steps toward quick and equitable roll-out of lenacapavir
The PURPOSE 1 and PURPOSE 2 trials last year showed outstanding efficacy of twice-yearly lenacapavir injections as HIV pre-exposure prophylaxis (PrEP). The journal Science named the drug the 2024 breakthrough of the year, reflecting a potential to reshape the HIV prevention landscape, and the development was widely covered in mainstream media. Although HIV remains a… Continue reading [Editorial] Steps toward quick and equitable roll-out of lenacapavir