Primary Immunodeficiency disorders (PID) can increase the risk of severe COVID-19 and prolonged infection. This study investigates the duration of SARS-CoV-2 excretion and the genetic evolution of the virus in… Continue reading on BioMed Central
Tag: Immunodeficiency Disorders
Associated factors and prognostic implications of neutropenia in individuals with HIV/AIDS
Neutropenia frequently presents as a hematological manifestation among people living with HIV/AIDS (PLWHA). This study explores the factors associated with neutropenia in PLWHA and its prognostic significance. Continue reading on BioMed Central
High frequency CCR5 editing in human hematopoietic stem progenitor cells protects xenograft mice from HIV infection
Abstract The only cure of HIV has been achieved in a small number of people who received a hematopoietic stem cell transplant (HSCT) comprising allogeneic cells carrying a rare, naturally occurring, homozygous deletion in the CCR5 gene. The rarity of the mutation and the significant morbidity and mortality of such allogeneic transplants precludes widespread adoption… Continue reading High frequency CCR5 editing in human hematopoietic stem progenitor cells protects xenograft mice from HIV infection
Sustained virologic suppression of multidrug-resistant HIV in an individual treated with anti-CD4 domain 1 antibody and lenacapavir
Abstract The clinical management of people with multidrug-resistant (MDR) human immunodeficiency virus (HIV) remains challenging despite continued development of antiretroviral agents. A 58-year-old male individual with MDR HIV and Kaposi sarcoma (KS) was treated with a new antiretroviral regimen consisting of anti-CD4 domain 1 antibody UB-421 and capsid inhibitor lenacapavir. The individual experienced delayed but… Continue reading Sustained virologic suppression of multidrug-resistant HIV in an individual treated with anti-CD4 domain 1 antibody and lenacapavir
Latent HIV-1 induction
HIV-1 persistence in the latently infected cell reservoir even during treatment with antiretroviral therapy (ART) eludes the HIV-1 cure. Preventing viral rebound after ART interruption is a goal of HIV-1 cure research. In Immunity, Moskovljevic et al. find that cognate antigen presentation induces HIV-1 transcription. The authors use ex vivo co-culture of autologous dendritic cells… Continue reading Latent HIV-1 induction
[Feature] Coffee with IAS President Beatriz Grinsztejn
Head of the STD/AIDS Clinical Research Laboratory at the Evandro Chagas National Institute of Infectology–Fiocruz, Brazil, Beatriz Grinsztejn, is now President of the International AIDS Society (IAS). Tony Kirby caught up with her for a coffee in Rio de Janeiro, where she lives and works.
[Editorial] Bleak prospects for HIV response under new US administration
The re-election of Donald Trump as the next President of the USA has raised serious concerns about the future of US health policy and the response to HIV in the USA and globally. In 2019, Trump announced the Ending the HIV Epidemic (EHE) initiative, with the aim to reduce new HIV infections by 75% by… Continue reading [Editorial] Bleak prospects for HIV response under new US administration