AI SummaryThe text discusses the persistence of the transcriptionally active HIV reservoir and its implications for people living with HIV, such as chronic immune activation and inflammation. It suggests that supplementing antiretroviral therapy with transcriptional inhibitors could help silence the transcriptionally active HIV reservoir to improve treatment outcomes.Persistence of the transcriptionally active HIV reservoir has… Continue reading Silencing the transcriptionally active HIV reservoir to improve treatment outcomes
Tag: Immunodeficiency Disorders
Conjugation of anti-HIV gp41 monoclonal antibody to a drug capable of targeting resting lymphocytes produces an effective cytotoxic anti-HIV immunoconjugate
Combining molecular transmission network analysis and spatial epidemiology to reveal HIV-1 transmission pattern among the older people in Nanjing, China
AI SummaryThis study combines molecular transmission network analysis and spatial epidemiology to examine the pattern of HIV-1 transmission among older people in Nanjing, China. The research aims to identify factors influencing transmission and provide insight into the spread of HIV infection in this demographic group.In China, the problem of HIV infection among the older people… Continue reading Combining molecular transmission network analysis and spatial epidemiology to reveal HIV-1 transmission pattern among the older people in Nanjing, China
A cGAS-mediated type I interferon response in human CD4+ T cells depends on productive infection and is conserved over HIV types and strains
HIV-1 adapts to lost IP6 coordination through second-site mutations that restore conical capsid assembly
AI SummaryThis article discusses how HIV-1 adapts to mutations in the capsid protein that affect capsid assembly. Specifically, viruses containing mutations in certain positively charged residues were found to acquire second-site mutations that restore nearly normal replication fitness. These mutations allow for the restoration of proper capsid assembly by compensating for the lost pentamers, enabling… Continue reading HIV-1 adapts to lost IP6 coordination through second-site mutations that restore conical capsid assembly
Early bone marrow alterations in patients with adenosine deaminase 2 deficiency across disease phenotypes and severities
Targeted immune intervention and stopping ART in model of SIV infection leads to control of viral replication and reservoirs
AI SummaryResearchers have demonstrated successful control of SIV replication and reduction of viral reservoirs by combining a strict infection model with interrupting ART. This immune-based approach builds on understanding the mechanisms of action of PD1 and IL-10 in regulating HIV persistence and immune dysfunction.Researchers have shown unprecedented control of SIV replication and decay of viral… Continue reading Targeted immune intervention and stopping ART in model of SIV infection leads to control of viral replication and reservoirs
Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption
AI SummaryThe research study focuses on the use of anti-IL-10 and anti-PD-1 treatment in controlling SIV viral rebound following analytical treatment interruption in rhesus macaques. The results show that a combination of these treatments led to durable control of viral rebound in most subjects. Key findings included the induction of inflammatory cytokines, proliferation of effector… Continue reading Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption
Safety and antiviral effect of a triple combination of HIV-1 broadly neutralizing antibodies: a phase 1/2a trial
AI SummaryThis research focuses on the safety and antiviral effects of using a triple combination of HIV-1 broadly neutralizing antibodies. Previous studies have shown that using single or two-antibody cocktails provided transient viral suppression. The triple combination is expected to improve neutralization coverage of global viruses, potentially leading to better viral suppression and reduced rebound.Abstract… Continue reading Safety and antiviral effect of a triple combination of HIV-1 broadly neutralizing antibodies: a phase 1/2a trial