Science Immunology, Volume 10, Issue 103, January 2025.
Tag: Immunodeficiency Disorders
Decoding HIV’s tactics
Scientists have unveiled insights into how HIV-1, the virus responsible for AIDS, skillfully hijacks cellular machinery for its own survival. By dissecting the molecular interplay between the virus and its host, the researchers identified novel strategies that HIV-1 employs to ensure its replication while suppressing the host’s cellular defenses.
Reactivation of latent HIV-1 by the glucocorticoid receptor modulator AZD9567
Resistance mutations that distinguish HIV-1 envelopes with discordant VRC01 phenotypes from multi-lineage infections in the HVTN703/HPTN081 trial: implications for cross-resistance
Erratum for Ara et al., “Mechanism of Enhanced HIV Restriction by Virion Coencapsidated Cytidine Deaminases APOBEC3F and APOBEC3G”
Incompletely closed HIV-1CH040 envelope glycoproteins resist broadly neutralizing antibodies while mediating efficient HIV-1 entry
Abstract HIV-1 envelope glycoproteins (Envs) mediate viral entry and are sole target of neutralizing antibodies. Thus, HIV-1 Envs must maintain a delicate balance between evading neutralizing antibodies while still preserving viral compatibility to mediate entry into target cells. Here, we studied the viral entry effeciency, fitness, and replication of an incompletely closed, transmitted/founder HIV-1 Envs… Continue reading Incompletely closed HIV-1CH040 envelope glycoproteins resist broadly neutralizing antibodies while mediating efficient HIV-1 entry
The translational landscape of HIV-1 infected cells reveals key gene regulatory principles
Abstract Human immunodeficiency virus-1 (HIV-1) uses a number of strategies to modulate viral and host gene expression during its life cycle. To characterize the transcriptional and translational landscape of HIV-1 infected cells, we used a combination of ribosome profiling, disome sequencing and RNA sequencing. We show that HIV-1 messenger RNAs are efficiently translated at all… Continue reading The translational landscape of HIV-1 infected cells reveals key gene regulatory principles
For healthy hearing, timing matters
When sound waves reach the inner ear, neurons there pick up the vibrations and alert the brain. Encoded in their signals is a wealth of information that enables us to follow conversations, recognize familiar voices, appreciate music, and quickly locate a ringing phone or crying baby. Neurons send signals by emitting spikes — brief changes… Continue reading For healthy hearing, timing matters
