Viruses, like those that cause COVID-19 or HIV, are formidable opponents once they invade our bodies. Antiviral treatments strive to block a virus or halt its replication. However, viruses are dynamic — constantly evolving and changing shape, which can make designing antiviral treatments a challenge.
Tag: Immunodeficiency Disorders
Non-AUG HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression
Abstract Human immunodeficiency virus type-1 (HIV-1) is a complex retrovirus that relies on alternative splicing, translational, and post-translational mechanisms to produce over 15 functional proteins from its single ~10 kb transcriptional unit. Using ribosome profiling, nascent protein labeling, RNA sequencing, and whole-proteomics of infected CD4 + T lymphocytes, we characterized the transcriptional, translational, and post-translational landscape during infection.… Continue reading Non-AUG HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression
Adulthood outcomes of thymic transplantation in a case of congenital athymia due to FOXN1 mutation
NK cell depletion in bispecific antibody therapy is associated with lack of HIV control after ART interruption
Abstract HIV infection remains incurable as the virus persists within a latent reservoir of CD4+T cells. Novel approaches to enhance immune responses against HIV are essential for effective control and potential cure of the infection. In this study, we designed a novel tetravalent bispecific antibody (Bi-Ab32/16) to simultaneously target the gp120 viral protein on infected… Continue reading NK cell depletion in bispecific antibody therapy is associated with lack of HIV control after ART interruption
Barcoded HIV-1 reveals viral persistence driven by clonal proliferation and distinct epigenetic patterns
Abstract The HIV reservoir consists of infected cells in which the HIV-1 genome persists as provirus despite effective antiretroviral therapy (ART). Studies exploring HIV cure therapies often measure intact proviral DNA levels, time to rebound after ART interruption, or ex vivo stimulation assays of latently infected cells. This study utilizes barcoded HIV to analyze the… Continue reading Barcoded HIV-1 reveals viral persistence driven by clonal proliferation and distinct epigenetic patterns
Immune-mediated strategies to solving the HIV reservoir problem
Abstract Antiretroviral therapy (ART) has markedly improved the life-expectancy of people living with HIV. However, during both HIV infection of humans and simian immunodeficiency virus infection of macaques, virus replication almost invariably rebounds upon ART interruption, due to the long-term persistency of a pool of latently infected cells harbouring integrated, replication-competent virus (known as the… Continue reading Immune-mediated strategies to solving the HIV reservoir problem
FBXO45 restricts HIV-1 replication by inducing SQSTM1/p62-mediated autophagic degradation of Tat
Activation of CXCR3+ Tfh cells and B cells in lymph nodes during acute HIV-1 infection correlates with HIV-specific antibody development
[ASAP] Pathway Specific Unbinding Free Energy Profiles of Ritonavir Dissociation from HIV-1 Protease
BiochemistryDOI: 10.1021/acs.biochem.4c00560