AI SummaryThis article discusses population-based germline breast cancer gene association studies and meta-analysis as a means to provide information for wider mainstream testing. It mentions the increasing trend of genetic testing being offered to a broader population of breast cancer patients and highlights the variation in genes included in these tests. This research aims to… Continue reading Population-based germline breast cancer gene association studies and meta-analysis to inform wider mainstream testing.
Tag: Huntington’s Disease
TWiV 1128: Clinical update with Dr. Daniel Griffin
AI SummaryDr. Griffin provides a weekly clinical update discussing various aspects related to the ongoing COVID-19 pandemic including statistics, treatment updates, and research findings. Key points covered in this episode include the fourth US case of H5N1 human infection, pasteurization definition, effectiveness of molnupiravir and dexamethasone, convalescent plasma, EEG use for cognitive decline after SARS-CoV-2… Continue reading TWiV 1128: Clinical update with Dr. Daniel Griffin
The Network Structure of Cognitive Impairment: From Subjective Cognitive Decline to Alzheimer’s Disease
AI SummaryThis article discusses how the relationships between cognitive functions change in dementia conditions such as Alzheimer’s disease, going beyond just a decline in specific domains. It explores this using exploratory graph analysis on neuropsychological assessments of individuals with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer’s disease (AD). The study found that… Continue reading The Network Structure of Cognitive Impairment: From Subjective Cognitive Decline to Alzheimer’s Disease
Chemotherapy disrupts gut microbiome in patients with breast cancer
AI SummaryThe text discusses how chemotherapy disrupts the gut microbiome in patients with breast cancer. This disruption may lead to cognitive decline due to the communication between the gut microbiome and the brain affecting behavior, including cognition. The study aims to investigate if chemotherapy-induced changes in the gut microbiome are linked to cognitive decline and… Continue reading Chemotherapy disrupts gut microbiome in patients with breast cancer
Diabetes mellitus and risk of incident dementia in APOE ɛ4 carriers: an updated meta-analysis
AI SummaryThis study focuses on the relationship between diabetes mellitus and the risk of dementia in individuals who carry the APOE ε4 gene. The research suggests that diabetes may increase the likelihood of developing dementia, mortality, and cognitive decline, especially in those with genetic risk factors. The study aims to provide an updated meta-analysis of… Continue reading Diabetes mellitus and risk of incident dementia in APOE ɛ4 carriers: an updated meta-analysis
Superagers Resist Typical Age-Related White Matter Structural Changes
AI SummaryThis study examines superagers, elderly individuals with cognitive abilities similar to people much younger than themselves. The research found that superagers show better white matter microstructure compared to typical older adults, indicating resistance to age-related cognitive decline. Superagers had higher fractional anisotropy (FA) and lower mean diffusivity (MD) in their white matter, especially in… Continue reading Superagers Resist Typical Age-Related White Matter Structural Changes
Edge-Community Entropy Is a Novel Neural Correlate of Aging and Moderator of Fluid Cognition
AI SummaryThis article discusses how decreased neuronal specificity in response to cognitive demands, known as neural dedifferentiation, is implicated in age-related cognitive decline. The study used an edge-centric network approach to measure entropy, a measure of specialization, from spatially overlapping communities during cognitive task fMRI. The results showed a pattern of nodal despecialization affecting different… Continue reading Edge-Community Entropy Is a Novel Neural Correlate of Aging and Moderator of Fluid Cognition
Genetic Tests May Help Identify Global Development Delay
AI SummaryGenetic tests can help identify global development delay more accurately, reducing misdiagnosis rates.Using combined genetic testing in early childhood may decrease the misdiagnosis rate for Global Development Delay (GDD). MDedge News
Fluid Biomarker Changes After Amyloid-β–Targeting Drugs
AI SummaryThe article discusses the advancements in Alzheimer’s disease research, particularly focusing on measuring changes in biofluids like cerebrospinal fluid and plasma to detect amyloid-β and tau proteins. It highlights the effectiveness of monoclonal antibodies in reducing amyloid-β plaque burden and potential cognitive benefits, but also raises questions about other changes in the brain, such… Continue reading Fluid Biomarker Changes After Amyloid-β–Targeting Drugs
The role of family history in predicting germline pathogenic variant carriers who develop pancreatic cancer: Results of a multicenter collaboration
AI SummaryThis study focused on the role of family history in predicting germline pathogenic variant carriers who develop pancreatic cancer. The research found that while most carriers did not have a close family history of pancreatic cancer, they were more likely to have a family history, particularly in first-degree relatives. This highlights the importance of… Continue reading The role of family history in predicting germline pathogenic variant carriers who develop pancreatic cancer: Results of a multicenter collaboration