Subtle signs of neurodegeneration can be detected in blood, CSF, and neuroimaging, up to 20 years before the motor symptoms of Huntington’s disease present. Medscape Medical News
Tag: Huntington’s Disease
Huntington’s Disease: Can Beta Blockers Help?
Beta blockers were associated with later appearance of motor symptoms and slower symptom worsening, but an outside expert questioned their appropriateness for Huntington’s disease. Medscape Medical News
[Review] Unique considerations in the assessment and management of traumatic brain injury in older adults
The age-specific incidence of traumatic brain injury in older adults is rising in high-income countries, mainly due to an increase in the incidence of falls. The severity of traumatic brain injury in older adults can be underestimated because of a delay in the development of mass effect and symptoms of intracranial haemorrhage. Management and rehabilitation… Continue reading [Review] Unique considerations in the assessment and management of traumatic brain injury in older adults
Losing Your Mind Trying to Understand the BP-Dementia Link
Cardiologist Christopher Labos reviews the data on blood pressure control and dementia in the context of recent studies suggesting that discontinuing antihypertensives may slow cognitive decline. theheart.org on Medscape
[ASAP] Small CAG Repeat RNA Forms a Duplex Structure with Sticky Ends That Promote RNA Condensation
RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington’s disease models
HD is a devastating neurodegenerative disorder caused by the expansion of CAG repeats in the HTT. Silencing the expression of mutated proteins is a therapeutic direction to rescue HD patients, and recent advances…
Erratum: Tosi et al., “The Network Structure of Cognitive Impairment: From Subjective Cognitive Decline to Alzheimer’s Disease”
Gantenerumab in Dominantly Inherited Alzheimer Disease
To the Editor Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell surface receptor of microglia, and its stimulation enhances the phagocytic activity of microglia and modulates inflammatory signaling. The activation of TREM2 in response to the presence of amyloid β (Aβ) plaques and tau tangles plays a crucial role in the pathogenesis… Continue reading Gantenerumab in Dominantly Inherited Alzheimer Disease
Deferiprone in Alzheimer Disease
This randomized clinical trial investigates whether the brain-permeable iron chelator deferiprone slows cognitive decline in people with Alzheimer disease.
β-Blocker Use and Delayed Onset and Progression of Huntington Disease
This study evaluates the impact of β-blockers on the timing of motor diagnosis onset and progression of Huntington disease symptoms.