Huntington’s disease (HD), a neurodegenerative disease, affects approximately 30,000 people in the United States, with 200,000 more at risk. Mitochondrial dysfunction caused by mutant huntingtin (mHTT) drives early HD pathophysiology. mHTT binds the translocase of the mitochondrial inner membrane (TIM23) complex, inhibiting mitochondrial protein import and altering the mitochondrial proteome. The 17 aa HTT N-terminal sequence… Continue reading Regulation of Mutant Huntingtin Mitochondrial Toxicity by Phosphomimetic Mutations within Its N-Terminal Region
Tag: Huntington’s Disease
Infant exposure to herpes virus may cause memory problems later in life
Very early exposure to even a very small dose of herpes simplex virus (HSV) in infant mice can lead to cognitive decline later in life, according to findings from a new Dartmouth-led study, in collaboration with Harvard Medical School and published in the journal PLoS Pathogens. This is significant because of emerging data in human studies showing… Continue reading Infant exposure to herpes virus may cause memory problems later in life
New research shows neonatal HSV infections may lead to long-term cognitive impairment
Very early exposure to even a very small dose of herpes simplex virus (HSV) in infant mice can lead to cognitive decline later in life, according to new findings. This is significant because of emerging data in human studies showing an association between HSV and Alzheimer’s disease in humans.
First-Time TIAs Linked With Long-Term Cognitive Decline
Recent findings suggest that healthcare providers should be conducting cognitive screening in patients who have experienced their first TIA. Medscape Medical News
Fluctuating Cholesterol Tied to Dementia, Cognitive Decline
High levels of variability in cholesterol over time were linked to a significantly higher risk for dementia and cognitive decline in older adults, a new study found. Medscape Medical News
Somatic CAG-repeat expansion drives neuronal loss in Huntington’s disease
Using single-cell technologies on postmortem brains, Handsaker et al. have demonstrated that substantial somatic expansion of the CAG repeat that causes Huntington’s disease results in progressive transcriptional dysregulation and drives the loss of spiny projection neurons in the caudate.
Pediatricians Leverage Genetic Testing for Faster Diagnoses
Health systems across the country are making it easier for primary care clinicians to order genetic tests for patients who may have neurodevelopmental conditions in an effort to enhance treatment. Medscape Medical News
Normal Serum Tryptase Levels Can Be Associated With TPSAB1 Mutation In Hereditary Alpha Tryptasemia Patients
Healthcare providers’ experiences with genetic testing in patients at risk or living with hereditary angioedema
University of Oklahoma researcher leads efforts to unravel mysteries of cognitive decline
An estimated 76,000 Oklahomans are living with Alzheimer’s disease, a number that has surged by 13% in just five years. Yet, despite the increasing need for effective treatments, therapies for age-related dementia have largely failed to slow or halt the disease’s progression. Now, a University of Oklahoma researcher, backed by $2.2 million in federal funding,… Continue reading University of Oklahoma researcher leads efforts to unravel mysteries of cognitive decline