Cardiologist Christopher Labos reviews the data on blood pressure control and dementia in the context of recent studies suggesting that discontinuing antihypertensives may slow cognitive decline. theheart.org on Medscape
Tag: Huntington’s Disease
[ASAP] Small CAG Repeat RNA Forms a Duplex Structure with Sticky Ends That Promote RNA Condensation
RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington’s disease models
HD is a devastating neurodegenerative disorder caused by the expansion of CAG repeats in the HTT. Silencing the expression of mutated proteins is a therapeutic direction to rescue HD patients, and recent advances…
Erratum: Tosi et al., “The Network Structure of Cognitive Impairment: From Subjective Cognitive Decline to Alzheimer’s Disease”
Gantenerumab in Dominantly Inherited Alzheimer Disease
To the Editor Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell surface receptor of microglia, and its stimulation enhances the phagocytic activity of microglia and modulates inflammatory signaling. The activation of TREM2 in response to the presence of amyloid β (Aβ) plaques and tau tangles plays a crucial role in the pathogenesis… Continue reading Gantenerumab in Dominantly Inherited Alzheimer Disease
Deferiprone in Alzheimer Disease
This randomized clinical trial investigates whether the brain-permeable iron chelator deferiprone slows cognitive decline in people with Alzheimer disease.
β-Blocker Use and Delayed Onset and Progression of Huntington Disease
This study evaluates the impact of β-blockers on the timing of motor diagnosis onset and progression of Huntington disease symptoms.
Beta-Blockers Show Promise in Curbing HD Progression
Beta-blockers are linked to delayed motor decline in premanifest Huntington disease and reduced symptom progression in early motor-manifest disease, new research suggests. Medscape Medical News
Chronological versus immunological aging: Immune rejuvenation to arrest cognitive decline
Basurco and Abellanas et al. discuss how immune system aging negatively impacts the brain and propose immune rejuvenation as a strategy to combat cognitive decline and sustain lifelong brain health.
[Comment] Autoimmune encephalitis: diagnostic challenges and tensions
Autoimmune encephalitis is an important and treatable cause of acute or subacute neurological disturbance. To optimise outcomes, several factors are crucial. First, education of the medical community is a priority, so that autoimmune encephalitis is considered in the differential diagnosis of diverse presentations such as new onset psychosis, seizures, and cognitive decline. Second, to support… Continue reading [Comment] Autoimmune encephalitis: diagnostic challenges and tensions