US President’s Emergency Plan for AIDS Relief (PEPFAR) supports HIV programmes in low-income countries hit hardest by HIV/AIDS . 20 million people are currently on HIV treatment and 1·5 million have access to pre-exposure prophylaxis thanks to PEPfAR . Over US$110 billion of investment has reshaped health systems: increasing surveillance capacity, creating large networks of… Continue reading [Editorial] PEPFAR reauthorisation hangs in the balance
Tag: HIV/AIDS
[Review] Metabolic implications and safety of dolutegravir use in pregnancy
Dolutegravir is recommended for all people living with HIV because of its efficacy, high barrier to resistance, favourable safety and tolerability profile . It has been associated with metabolic complications, including weight gain and rare events of hyperglycaemia, that could affect maternal, fetal, and postnatal health .
[Viewpoint] Global HIV control: is the glass half empty or half full?
The massive scale-up of HIV treatment and prevention over the past two decades has resulted in important reductions in new infections and mortality globally . Reduction in HIV incidence has been unequal, however, with worsening epidemics in regions where the reach and scale of . HIV control programmes have been insufficient, especially in eastern Europe,… Continue reading [Viewpoint] Global HIV control: is the glass half empty or half full?
A new peptide may hold potential as an Alzheimer’s treatment
AI SummaryMIT neuroscientists have discovered a peptide that can reverse neurodegeneration and other symptoms of Alzheimer’s disease by interfering with an enzyme called CDK5 that is overactive in Alzheimer’s patients. In mice, the peptide led to reductions in neurodegeneration, DNA damage, and improvements in cognitive abilities, leading researchers to believe it could serve as a… Continue reading A new peptide may hold potential as an Alzheimer’s treatment
Five from MIT named 2023 Quad Fellows
AI SummaryFour MIT alumni and a Harvard-MIT doctoral student have been selected for the inaugural class of the Quad Fellowship, a joint initiative of the governments of Australia, India, Japan, and the United States. The fellowship aims to support exceptional individuals pursuing STEM graduate study in the United States and provides a $50,000 award for… Continue reading Five from MIT named 2023 Quad Fellows
Alzheimer’s risk gene undermines insulation of brain’s “wiring”
AI SummaryA new study published in Nature by an MIT-based team provides insight into how the APOE4 gene variant increases the risk for Alzheimer’s disease. The study shows that APOE4 disrupts the management of cholesterol in brain cells called oligodendrocytes, leading to a deficiency in the fatty insulation of neurons known as myelin, which impairs… Continue reading Alzheimer’s risk gene undermines insulation of brain’s “wiring”