Tag: HIV/AIDS

The human cellular protein NoL12 is a specific partner of the HIV-1 nucleocapsid protein NCp7

Jäger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, Stephens M, D’Orso I, Fernandes J, Fahey M, Mahon C, O’Donoghue AJ, Todorovic A, Morris JH, Maltby DA, Alber T, Cagney G, Bushman FD, Young… Continue reading The human cellular protein NoL12 is a specific partner of the HIV-1 nucleocapsid protein NCp7

Alterations in gp120 glycans or the gp41 fusion peptide-proximal region modulate the stability of the human immunodeficiency virus (HIV-1) envelope glycoprotein pretriggered conformation

Xu K, Acharya P, Kong R, Cheng C, Chuang G-Y, Liu K, Louder MK, O’Dell S, Rawi R, Sastry M, Shen C-H, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill… Continue reading Alterations in gp120 glycans or the gp41 fusion peptide-proximal region modulate the stability of the human immunodeficiency virus (HIV-1) envelope glycoprotein pretriggered conformation

Broadly neutralizing antibody epitopes on HIV-1 particles are exposed after virus interaction with host cells

INTRODUCTIONThe envelope (Env) glycoprotein of human immunodeficiency virus type-1 (HIV-1) is the virus attachment protein that interacts with the host-cell receptor CD4 and chemokine receptors CCR5 or CXCR4 to initiate infection (1). HIV-1 displays an average of 7–14 Env trimers per particle. However, this number varies among isolates (2). Env is synthesized as a gp160… Continue reading Broadly neutralizing antibody epitopes on HIV-1 particles are exposed after virus interaction with host cells

Transcription start site heterogeneity and its role in RNA fate determination distinguish HIV-1 from other retroviruses and are mediated by core promoter elements

Carninci P, Sandelin A, Lenhard B, Katayama S, Shimokawa K, Ponjavic J, Semple CAM, Taylor MS, Engström PG, Frith MC, Forrest ARR, Alkema WB, Tan SL, Plessy C, Kodzius R, Ravasi T, Kasukawa T, Fukuda S, Kanamori-Katayama M, Kitazume Y, Kawaji H, Kai C, Nakamura M, Konno H, Nakano K, Mottagui-Tabar S, Arner P, Chesi… Continue reading Transcription start site heterogeneity and its role in RNA fate determination distinguish HIV-1 from other retroviruses and are mediated by core promoter elements

Viral suppression rate at operation triple zero (Otz) and regular art follow-Up programs and associated factors among adolescent clients of Addis Ababa Ethiopia: a comparative cross-sectional study

– Viral suppression is the main goal of currently available treatment and it is used as a primary indicator of successful treatment for human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AID… Continue reading on BioMed Central

CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells

INTRODUCTIONThe ability of HIV-1 to persist within infected cells as an integrated provirus, even during suppressive antiretroviral therapy (ART), represents the main barrier to achieve ART-free HIV remission or cure (1, 2). Various strategies to inactivate or eliminate latent viral reservoirs have been proposed, many of which involve approaches to modulate proviral expression (1, 3).… Continue reading CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells

[Editorial] Negligible role of suppressed HIV in sexual transmission

WHO launched the policy brief The Role of HIV Viral Suppression in Improving Individual Health and Reducing Transmission at the 12th International AIDS Society Conference on HIV Science in Brisbane, Australia . It has long been known that undetectable (typically a VL of <200 copies per mL) means that people living with HIV (PLHIV) are… Continue reading [Editorial] Negligible role of suppressed HIV in sexual transmission