Tag: Epilepsy

[Editorial] Improving access to medicines for neurological disorders

AI SummaryThis editorial discusses the global public health challenge posed by neurological disorders and the WHO’s Intersectoral Global Action Plan on Epilepsy and Other Neurological Disorders (IGAP) aimed at improving access to care for individuals with neurological disorders. The WHO aims to have 80% of countries providing essential medicines for neurological disorders in primary care… Continue reading [Editorial] Improving access to medicines for neurological disorders

Experience Dependence of Alpha Rhythms and Neural Dynamics in the Mouse Visual Cortex

AI SummaryThis study explored how early-life experiences impact cortical dynamics in the visual cortex of adult, head-fixed mice. Two forms of blindness were induced before eye opening and were shown to have unique effects on network behavior. Enucleation led to changes in low-frequency synchronization during movement, resembling human alpha oscillations, while eyelid suture altered neural… Continue reading Experience Dependence of Alpha Rhythms and Neural Dynamics in the Mouse Visual Cortex

Neural Activity Differentiates Novel and Learned Event Boundaries

AI SummaryThis article discusses how neural activity differentiates between novel and learned event boundaries. The study involved exposing participants to a sequence of images and then testing their ability to segment another sequence based on learned transitions between communities and novel transitions. The results showed that participants could segment experiences into events based on both… Continue reading Neural Activity Differentiates Novel and Learned Event Boundaries

Chinese Verbal Fluency Deficiency in Temporal Lobe Epilepsy with and without Hippocampal Sclerosis: A Multiscale Study

AI SummaryIn this study, a Chinese character version of the phonemic verbal fluency task was tested in patients with temporal lobe epilepsy (TLE) to assess verbal fluency deficiency in TLE with and without hippocampal sclerosis. The results showed activation and deactivation deficiency in both TLE-HS and TLE-NHS, with impaired functional connectivity, degree centrality, and community… Continue reading Chinese Verbal Fluency Deficiency in Temporal Lobe Epilepsy with and without Hippocampal Sclerosis: A Multiscale Study

[In Context] Learning to be an adult with a disability

21-year-old Samuel Habib has a rare genetic neurodevelopmental disorder, which was diagnosed in 2019 as being caused by mutations in the GNAO1 gene. The disorder is progressive, and individuals can experience dysfunction in their movement, seizures, and swallowing difficulties. Because of his complex needs, Samuel is fully dependent on his family and carers. He uses… Continue reading [In Context] Learning to be an adult with a disability

Study assesses seizure risk from stimulating the thalamus

AI SummaryResearchers from MIT and Massachusetts General Hospital conducted a study assessing seizure risk associated with electrically stimulating the central thalamus in awake mice. The study found that electrographic seizures occurred in 10 out of 12 mice in response to CT-DBS, even at low current levels. Seizure risk increased with higher current levels, independent of… Continue reading Study assesses seizure risk from stimulating the thalamus

Gabapentin: The Hope, the Harm, the Myth, the Reality

AI SummaryThe article discusses the use, side effects, and safety warnings of gabapentin, a medication originally approved for partial-onset seizures and postherpetic neuralgia.Douglas S. Paauw, MD, explores the use, side effects and safety warnings of gabapentin, originally approved to treat partial-onset seizures and postherpetic neuralgia. MDedge

Prevalence of Epilepsy in People of Sexual and Gender Minoritized Groups

AI SummaryThis study aims to determine the prevalence of active epilepsy among people of sexual and gender minoritized groups in the United States using data from the 2022 National Health Interview Survey. This research is important to shed light on potential disparities in healthcare outcomes and needs within these underrepresented populations.This cross-sectional study using data… Continue reading Prevalence of Epilepsy in People of Sexual and Gender Minoritized Groups

Risk of Perinatal and Maternal Morbidity and Mortality Among Pregnant Women With Epilepsy

AI SummaryThis study aims to assess the risk of complications for pregnant women with epilepsy, including severe maternal and perinatal morbidity and mortality. The research will provide valuable insights into the unique challenges faced by women with epilepsy during pregnancy, potentially leading to improvements in care and outcomes in this population.This study attempts to determine… Continue reading Risk of Perinatal and Maternal Morbidity and Mortality Among Pregnant Women With Epilepsy