The Scottish National Gallery in Edinburgh, UK, is no stranger to unusual exhibitions and events, from Pin-Ups: Toulouse-Lautrec and the art of celebrity through to television comedian Phill Jupitus doodling pictures and telling jokes during his Sketch comedy sessions. Yet the arrival of Art on the brain—a touring project organised by Art Fund, a charity… Continue reading [In Context] Monitoring brainwaves while gallery visitors view artworks
Tag: Epilepsy
Spatiotemporal Mapping of Auditory Onsets during Speech Production
The human auditory cortex is organized according to the timing and spectral characteristics of speech sounds during speech perception. During listening, the posterior superior temporal gyrus is organized according to onset responses, which segment acoustic boundaries in speech, and sustained responses, which further process phonological content. When we speak, the auditory system is actively processing… Continue reading Spatiotemporal Mapping of Auditory Onsets during Speech Production
Prenatal Stress Tied to Higher Risk for Childhood Epilepsy
Persistent prenatal distress is associated with a significantly increased risk for epilepsy in offspring, new research showed. Medscape Medical News
Potassium ion channel modulation at cancer-neural interface enhances neuronal excitability in epileptogenic glioblastoma multiforme
This paper explores the interaction between glioblastoma multiforme (GBM) and the central nervous system, focusing on potassium ion channels’ role in neuronal excitability and GBM-associated epilepsy. It finds that increased KCND2 levels in OPC-like cancer cells at the cancer-neural interface, which raises extracellular potassium and increases neuronal excitability.
3-Thio-3,4,5-Trisubstituted-1,2,4-Triazoles: High Affinity Somatostatin Receptor-4 Agonist Synthesis and Structure-Activity Relationships
Somatostatin receptor-4 (SST4) is a therapeutic target for several conditions, including Alzheimer’s disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST4 binding affinity, selectivity, and functional activity. Herein we report the discovery of 3-thio-1,2,4-triazole series as selective and high affinity SST4 agonists. Thirty-three compounds show 300-fold selectivity over… Continue reading 3-Thio-3,4,5-Trisubstituted-1,2,4-Triazoles: High Affinity Somatostatin Receptor-4 Agonist Synthesis and Structure-Activity Relationships
The Effect of Congruent versus Incongruent Distractor Positioning on Electrophysiological Signals during Perceptual Decision-Making
Key event-related potentials (ERPs) of perceptual decision-making such as centroparietal positivity (CPP) elucidate how evidence is accumulated toward a given choice. Furthermore, this accumulation can be impacted by visual target selection signals such as the N2 contralateral (N2c). How these underlying neural mechanisms of perceptual decision-making are influenced by the spatial congruence of distractors relative… Continue reading The Effect of Congruent versus Incongruent Distractor Positioning on Electrophysiological Signals during Perceptual Decision-Making
Spatiotemporal Neural Network for Sublexical Information Processing: An Intracranial SEEG Study
Words offer a unique opportunity to separate the processing mechanisms of object subcomponents from those of the whole object, because the phonological or semantic information provided by the word subcomponents (i.e., sublexical information) can conflict with that provided by the whole word (i.e., lexical information). Previous studies have revealed some of the specific brain regions… Continue reading Spatiotemporal Neural Network for Sublexical Information Processing: An Intracranial SEEG Study
EphB2 Signaling Is Implicated in Astrocyte-Mediated Parvalbumin Inhibitory Synapse Development
Impaired inhibitory synapse development is suggested to drive neuronal hyperactivity in autism spectrum disorders (ASD) and epilepsy. We propose a novel mechanism by which astrocytes control the development of parvalbumin (PV)-specific inhibitory synapses in the hippocampus, implicating ephrin-B/EphB signaling. Here, we utilize genetic approaches to assess functional and structural connectivity between PV and pyramidal cells… Continue reading EphB2 Signaling Is Implicated in Astrocyte-Mediated Parvalbumin Inhibitory Synapse Development
1276 Spatial mapping of intra-tumoral bacterial signal in primary and metastatic brain tumors
Background Despite significant advances in understanding the role of microbiome in cancer and tumor immunity, the impact of microbiome in primary and metastatic brain tumors remains largely unknown. Elucidating the dynamic interaction between microbial entities and the brain tumor microenvironment can provide novel microbiome-based opportunities to enhance care for brain tumor patients. Methods Brain tumor… Continue reading 1276 Spatial mapping of intra-tumoral bacterial signal in primary and metastatic brain tumors
Antiseizure Medication Use and Outcomes After Suspected or Confirmed Acute Symptomatic Seizures
This cohort study examines factors and outcomes associated with antiseizure medication use in patients with confirmed or suspected acute symptomatic seizures.