While previous works established the inhibitory role of alpha oscillations during working memory maintenance, it remains an open question whether such an inhibitory control is a top-down process. Here, we attempted to disentangle this issue by considering the spatiotemporal component of waves in the alpha band, i.e., alpha traveling waves. We reanalyzed two pre-existing and… Continue reading Alpha Traveling Waves during Working Memory: Disentangling Bottom-Up Gating and Top-Down Gain Control
Tag: Epilepsy
Women Largely Unaware of ASM Risks, More Education Needed
The majority of women with epilepsy are inadequately educated about the potential risks for ASMs, including teratogenic effects and reduced efficacy of hormonal birth control. Medscape Medical News
Smart Mattress to Reduce SUDEP?
Combined with a seizure detection device, an innovative mattress could cut cases of sudden unexpected death in epilepsy by an estimated 50%. Medscape Medical News
Sleep Apnea Linked to Heightened Mortality in Epilepsy
The magnitude was much greater in children than adults, and central sleep apnea was tied to greater risk than obstructive sleep apnea. Medscape Medical News
Developmental Syngap1 Haploinsufficiency in Medial Ganglionic Eminence-Derived Interneurons Impairs Auditory Cortex Activity, Social Behavior, and Extinction of Fear Memory
Mutations in SYNGAP1, a protein enriched at glutamatergic synapses, cause intellectual disability associated with epilepsy, autism spectrum disorder, and sensory dysfunctions. Several studies showed that Syngap1 regulates the time course of forebrain glutamatergic synapse maturation; however, the developmental role of Syngap1 in inhibitory GABAergic neurons is less clear. GABAergic neurons can be classified into different… Continue reading Developmental Syngap1 Haploinsufficiency in Medial Ganglionic Eminence-Derived Interneurons Impairs Auditory Cortex Activity, Social Behavior, and Extinction of Fear Memory
Editors’ Picks, November 2024: Cervical Cancer in Native Americans, Nanovaccines, and More
The cover of Cancer Prevention Research was adopted from a figure in the study that showed the abundance of bacteria in the vaginal microbiome. As we head into the holiday season, Cancer Research Catalyst has tantalizing teasers in the form of science stocking stuffers straight from our November edition of Editors’ Picks. This month, the… Continue reading Editors’ Picks, November 2024: Cervical Cancer in Native Americans, Nanovaccines, and More
Development and Validation of a Clinical Score to Predict Epilepsy After Cerebral Venous Thrombosis
This study attempts to develop and externally validate a prognostic score to estimate the individual risk of postcerebral venous thrombosis epilepsy.
Genome Sequencing After Exome Sequencing in Pediatric Epilepsy
This cohort study examined the yield and use of genome sequencing after nondiagnostic exome sequencing for pediatric patients with unexplained epilepsy between August 2018 and May 2023.
Haploinsufficiency of Syngap1 in Striatal Indirect Pathway Neurons Alters Motor and Goal-Directed Behaviors in Mice
SYNGAP1 is a high-confidence autism spectrum disorder (ASD) risk gene, and mutations in SYNGAP1 lead to a neurodevelopmental disorder (NDD) that presents with epilepsy, ASD, motor developmental delay, and intellectual disability. SYNGAP1 codes for Ras/Rap GTP-ase activating protein SynGAP (SynGAP). SynGAP is located in the postsynaptic density of glutamatergic synapses and regulates glutamate receptor trafficking… Continue reading Haploinsufficiency of Syngap1 in Striatal Indirect Pathway Neurons Alters Motor and Goal-Directed Behaviors in Mice
A “Conscious” Loss of Balance: Directing Attention to Movement Can Impair the Cortical Response to Postural Perturbations
“Trying too hard” can interfere with skilled movement, such as sports and music playing. Postural control can similarly suffer when conscious attention is directed toward it (“conscious movement processing”; CMP). However, the neural mechanisms through which CMP influences balance remain poorly understood. We explored the effects of CMP on electroencephalographic (EEG) perturbation-evoked cortical responses and… Continue reading A “Conscious” Loss of Balance: Directing Attention to Movement Can Impair the Cortical Response to Postural Perturbations