Tag: Epilepsy

Developmental Syngap1 Haploinsufficiency in Medial Ganglionic Eminence-Derived Interneurons Impairs Auditory Cortex Activity, Social Behavior, and Extinction of Fear Memory

Mutations in SYNGAP1, a protein enriched at glutamatergic synapses, cause intellectual disability associated with epilepsy, autism spectrum disorder, and sensory dysfunctions. Several studies showed that Syngap1 regulates the time course of forebrain glutamatergic synapse maturation; however, the developmental role of Syngap1 in inhibitory GABAergic neurons is less clear. GABAergic neurons can be classified into different… Continue reading Developmental Syngap1 Haploinsufficiency in Medial Ganglionic Eminence-Derived Interneurons Impairs Auditory Cortex Activity, Social Behavior, and Extinction of Fear Memory

Editors’ Picks, November 2024: Cervical Cancer in Native Americans, Nanovaccines, and More

The cover of Cancer Prevention Research was adopted from a figure in the study that showed the abundance of bacteria in the vaginal microbiome. As we head into the holiday season, Cancer Research Catalyst has tantalizing teasers in the form of science stocking stuffers straight from our November edition of Editors’ Picks. This month, the… Continue reading Editors’ Picks, November 2024: Cervical Cancer in Native Americans, Nanovaccines, and More

Haploinsufficiency of Syngap1 in Striatal Indirect Pathway Neurons Alters Motor and Goal-Directed Behaviors in Mice

SYNGAP1 is a high-confidence autism spectrum disorder (ASD) risk gene, and mutations in SYNGAP1 lead to a neurodevelopmental disorder (NDD) that presents with epilepsy, ASD, motor developmental delay, and intellectual disability. SYNGAP1 codes for Ras/Rap GTP-ase activating protein SynGAP (SynGAP). SynGAP is located in the postsynaptic density of glutamatergic synapses and regulates glutamate receptor trafficking… Continue reading Haploinsufficiency of Syngap1 in Striatal Indirect Pathway Neurons Alters Motor and Goal-Directed Behaviors in Mice

A “Conscious” Loss of Balance: Directing Attention to Movement Can Impair the Cortical Response to Postural Perturbations

“Trying too hard” can interfere with skilled movement, such as sports and music playing. Postural control can similarly suffer when conscious attention is directed toward it (“conscious movement processing”; CMP). However, the neural mechanisms through which CMP influences balance remain poorly understood. We explored the effects of CMP on electroencephalographic (EEG) perturbation-evoked cortical responses and… Continue reading A “Conscious” Loss of Balance: Directing Attention to Movement Can Impair the Cortical Response to Postural Perturbations

[In Context] Monitoring brainwaves while gallery visitors view artworks

The Scottish National Gallery in Edinburgh, UK, is no stranger to unusual exhibitions and events, from Pin-Ups: Toulouse-Lautrec and the art of celebrity through to television comedian Phill Jupitus doodling pictures and telling jokes during his Sketch comedy sessions. Yet the arrival of Art on the brain—a touring project organised by Art Fund, a charity… Continue reading [In Context] Monitoring brainwaves while gallery visitors view artworks

Spatiotemporal Mapping of Auditory Onsets during Speech Production

The human auditory cortex is organized according to the timing and spectral characteristics of speech sounds during speech perception. During listening, the posterior superior temporal gyrus is organized according to onset responses, which segment acoustic boundaries in speech, and sustained responses, which further process phonological content. When we speak, the auditory system is actively processing… Continue reading Spatiotemporal Mapping of Auditory Onsets during Speech Production