The subiculum represents a crucial brain pivot in regulating seizure generalization in temporal lobe epilepsy (TLE), primarily through a synergy of local GABAergic and long-projecting glutamatergic signaling. However, little is known about how subicular GABAergic interneurons are involved in a cell-type–specific way. Here, employing Ca2+ fiber photometry, retrograde monosynaptic viral tracing, and chemogenetics in epilepsy… Continue reading Circuit Reorganization of Subicular Cell-Type-Specific Interneurons in Temporal Lobe Epilepsy
Tag: Epilepsy
Multivariate Pattern Analysis of EEG Reveals Neural Mechanism of Naturalistic Target Processing in Attentional Blink
The human brain has inherent limitations in consciously processing visual information. When individuals monitor a rapid sequence of images for detecting two targets, they often miss the second target (T2) if it appears within a short time frame of 200–500 ms after the first target (T1), a phenomenon known as the attentional blink (AB). The… Continue reading Multivariate Pattern Analysis of EEG Reveals Neural Mechanism of Naturalistic Target Processing in Attentional Blink
Can Sea Lions Expand Our Knowledge of Epilepsy?
The experimental treatment used to treat the prolonged seizures of a sea lion may offer insights into treatment approaches that can help humans. Medscape Medical News
[ASAP] Application and Mechanism of Action of a Ketogenic Diet in Antiepileptic Therapy
Gestational Eclampsia Linked to Fivefold Epilepsy Risk
A new study links gestational hypertension, eclampsia, or preeclampsia to new-onset neurologic conditions, underscoring the importance of pregnancy history, researchers said. Medscape Medical News
MIT affiliates awarded 2024 National Medals of Science, Technology
Four MIT faculty members are among 23 world-class researchers who have been awarded the nation’s highest honors for scientists and innovators, the White House announced today. Angela Belcher and Emery Brown were each presented with the National Medal of Science at a White House ceremony this afternoon, and Paula Hammond ’84, PhD ’93, and Feng… Continue reading MIT affiliates awarded 2024 National Medals of Science, Technology
Feng Zhang awarded 2024 National Medal of Technology
This post is adapted from an MIT News story. *** Four MIT faculty members are among 23 world-class researchers who have been awarded the nation’s highest honors for scientists and innovators, the White House announced today. Angela Belcher and Emery Brown were each presented with the National Medal of Science at a White House ceremony… Continue reading Feng Zhang awarded 2024 National Medal of Technology
Oscillatory Brain Activity in the Canonical Alpha-Band Conceals Distinct Mechanisms in Attention
Brain oscillations in the alpha-band (8–14 Hz) have been linked to specific processes in attention and perception. In particular, decreases in posterior alpha-amplitude are thought to reflect activation of perceptually relevant brain areas for target engagement, while alpha-amplitude increases have been associated with inhibition for distractor suppression. Traditionally, these alpha-changes have been viewed as two facets… Continue reading Oscillatory Brain Activity in the Canonical Alpha-Band Conceals Distinct Mechanisms in Attention
Intracranial Voltage Profiles from Untangled Human Deep Sources Reveal Multisource Composition and Source Allocation Bias
Intracranial potentials are used as functional biomarkers of neural networks. As potentials spread away from the source populations, they become mixed in the recordings. In humans, interindividual differences in the gyral architecture of the cortex pose an additional challenge, as functional areas vary in location and extent. We used source separation techniques to disentangle mixing… Continue reading Intracranial Voltage Profiles from Untangled Human Deep Sources Reveal Multisource Composition and Source Allocation Bias
Neuropsychological Outcomes in Children of Women With Epilepsy
This nonrandomized clinical trial investigates the associations between fetal antiseizure medication exposure and subsequent neuropsychological abilities of the child.