The potential for cognitive motor dissociation in patients who are behaviourally unresponsive after a severe brain injury poses profound ethical challenges. An international study revealed that one in four patients who appear unresponsive to verbal commands is capable of doing cognitive tasks detected through functional MRI or EEG (ie, has cognitive motor dissociation). Cognitive motor… Continue reading [In Context] An ethical framework to assess covert consciousness
Tag: Epilepsy
Synaptic Vesicle Glycoprotein 2A Knockout in Parvalbumin and Somatostatin Interneurons Drives Seizures in the Postnatal Mouse Brain
Synaptic vesicle glycoprotein 2A (SV2A) is a presynaptic protein targeted by the antiseizure drug levetiracetam. One or more of the three SV2 genes is expressed in all neurons and is essential to normal neurotransmission. Loss of SV2A results in a seizure phenotype in mice and mutations in humans are also linked to congenital seizures. How… Continue reading Synaptic Vesicle Glycoprotein 2A Knockout in Parvalbumin and Somatostatin Interneurons Drives Seizures in the Postnatal Mouse Brain
Disinhibition across Secondary Motor Cortical Regions during Motor Sequence Learning: A TMS-EEG Study
Secondary motor cortical regions, such as the supplementary motor area (SMA), are involved in planning and learning motor sequences; however, the neurophysiological mechanisms across these secondary cortical networks remain poorly understood. In the primary motor cortex, changes in excitatory and inhibitory neurotransmission (E:I balance) accompany motor sequence learning. In particular, there is an early reduction… Continue reading Disinhibition across Secondary Motor Cortical Regions during Motor Sequence Learning: A TMS-EEG Study
Can a 15-Minute EEG Suffice for Critically Ill Patients?
Andrew Wilner speaks with fellow neurologist Karine Abou Khaled about her recent study on a 15-minute subdermal EEG with a simplified module for critically ill patients vs a full-head 24-hour EEG. Medscape Neurology
Gene therapy breakthrough offers hope for severe Dravet syndrome cases
Researchers successfully use an adeno-associated viral vector to restore brain function in a mouse model of SCN1B-linked DEE52, reducing seizures and extending lifespan, paving the way for future gene therapy in patients. Study: Neonatal but not Juvenile Gene Therapy Reduces Seizures and Prolongs Lifespan in SCN1B-Dravet Syndrome Mice. Image Credit: Natali _ Mis/Shutterstock.com Developmental and epileptic encephalopathies… Continue reading Gene therapy breakthrough offers hope for severe Dravet syndrome cases
A Less Invasive Route to Being Seizure-Free
Drs Andrew Wilner and Robert Gross discuss a minimally invasive approach to treating mesial temporal lobe epilepsy and how its efficacy compares with surgery. Medscape Neurology
New Tool Estimated to Cut Epilepsy Misdiagnoses by up to 70%
EpiScalp is a new tool designed to improve the accuracy of EEG recordings and reduce epilepsy misdiagnoses by as much as 70%, investigators report. Medscape Medical News
Epileptiform Electrographic Patterns After Cardiac Arrest
This Viewpoint challenges conventional clinical practice that eschews pharmacological intervention for comatose patients with epileptiform abnormalities after cardiac arrest using evidence from the Treatment of Electroencephalographic Status Epilepticus after Cardiopulmonary Resuscitation (TELSTAR) trial.
Gestational Hypertension, Preeclampsia, and Eclampsia and Future Neurological Disorders
This study explores whether gestational hypertension, preeclampsia, and eclampsia are associated with new-onset migraine, headache, epilepsy, sleep disorder, or mental fatigue within months to years after giving birth.
Circuit Reorganization of Subicular Cell-Type-Specific Interneurons in Temporal Lobe Epilepsy
The subiculum represents a crucial brain pivot in regulating seizure generalization in temporal lobe epilepsy (TLE), primarily through a synergy of local GABAergic and long-projecting glutamatergic signaling. However, little is known about how subicular GABAergic interneurons are involved in a cell-type–specific way. Here, employing Ca2+ fiber photometry, retrograde monosynaptic viral tracing, and chemogenetics in epilepsy… Continue reading Circuit Reorganization of Subicular Cell-Type-Specific Interneurons in Temporal Lobe Epilepsy